Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv2421c and Rv2422 are separated by 274 nucleotidesRv2422 and Rv2423 are separated by 241 nucleotidesRv2423 and Rv2424c are separated by 132 nucleotidesRv2424c and Rv2425c are separated by 88 nucleotides Rv2421c: Rv2421c - Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nicotinate mononucleotide adenylyltransferase) (NAMN adenylyltransferase), at 2,718,173 to 2,718,808 Rv2421c Rv2422: Rv2422 - Hypothetical protein, at 2,719,083 to 2,719,355 Rv2422 Rv2423: Rv2423 - Hypothetical protein, at 2,719,597 to 2,720,643 Rv2423 Rv2424c: Rv2424c - Probable transposase, at 2,720,776 to 2,721,777 Rv2424c Rv2425c: Rv2425c - Conserved hypothetical protein, at 2,721,866 to 2,723,308 Rv2425c
Group Condition Rv2421c Rv2422 Rv2423 Rv2424c Rv2425c
stress 7H9 with Isoniazid 0.025 ug/mL N.D. -1.1 -0.0 N.D. +0.1
stress 7H9 with Chloramphenicol 0.01 mM N.D. -0.8 +0.1 N.D. -0.0
no stress control no stress control N.D. -0.4 -0.1 N.D. -0.2
stress 7H9 with Sisomicin 0.07 mM N.D. -0.5 +0.1 N.D. +0.0
carbon source cholesterol 100uM (C) N.D. -0.5 +0.2 N.D. -0.1
pH pH 4.5 N.D. -0.4 -0.1 N.D. +0.3
stress 7H9 with Irgasan 0.065 mM N.D. -0.4 -0.1 N.D. +0.4
stress 7H9 with Bedaquiline 0.15 ug/mL N.D. -0.4 +0.1 N.D. +0.3
stress 7H9 with Ciprofloxacin Hydrochloride 0.001 mM N.D. +0.6 +0.0 N.D. -0.5
stress 7H9 with Ramoplanin 0.009 mM N.D. +0.6 -0.2 N.D. -0.1
stress 7H9 with Novobiocin 0.004 mM N.D. +0.5 +0.1 N.D. -0.2
stress 7H9 with Chlorhexidine diacetate salt 0.0021 mM N.D. +0.6 +0.0 N.D. -0.3
stress 7H9 with EDTA (disodium salt) 0.2 mM N.D. +0.6 -0.1 N.D. -0.1
no stress control no stress control N.D. +0.4 -0.2 N.D. +0.2
stress 7H9 with Zinc Pyrithione 0.00072 mM N.D. +0.3 -0.1 N.D. +0.3
stress 7H9 with Doxycycline hyclate 0.0035 mM N.D. +0.3 -0.1 N.D. +0.3
stress 7H9 with Formaldehyde 0.23 mM N.D. +0.6 -0.2 N.D. +0.1
stress 7H9 with Menadione 0.005 mM N.D. +0.5 -0.1 N.D. +0.2
stress 7H9 with Zinc Pyrithione 0.00072 mM N.D. +0.5 -0.1 N.D. +0.2
stress 7H9 with Dodecyl Sulfate 0.02 vol% N.D. +0.4 -0.0 N.D. +0.3
stress 7H9 with methylglyoxal 1.2 mM N.D. +0.8 -0.0 N.D. -0.1
stress 7H9 with Hydrogen peroxide 2.5 mM; pH 5.5 N.D. +0.3 -0.0 N.D. +0.4
stress 7H9 with nitrate 4 mM N.D. +0.4 -0.1 N.D. +0.3
stress 7H9 with copper (II) chloride 0.08 mM N.D. +0.3 +0.1 N.D. +0.3
stress 7H9 with Hydrogen peroxide 2.5 mM; pH 6.5 N.D. +0.4 +0.1 N.D. +0.3
nitrogen source L-Glutamine 10 mM (N) N.D. +0.9 -0.1 N.D. -0.0
stress 7H9 with 2-Mercaptopyridine N-oxide 0.0078 mM N.D. +0.5 +0.1 N.D. +0.1
stress 7H9 with Spectinomycin 0.029 mM N.D. +0.9 -0.0 N.D. -0.1
stress 7H9 with Menadione 0.005 mM N.D. +0.6 +0.0 N.D. +0.2
stress 7H9 with nitrite 1.5 mM; pH 5.5 N.D. +0.5 +0.1 N.D. +0.2
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