Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv2375 and Rv2376c are separated by 26 nucleotidesRv2376c and Rv2377c are separated by 99 nucleotidesRv2377c and Rv2378c overlap by 23 nucleotidesRv2378c and Rv2379c overlap by 4 nucleotides Rv2375: Rv2375 - Conserved hypothetical protein, at 2,655,265 to 2,655,582 Rv2375 Rv2376c: Rv2376c - Low molecular weight antigen CFP2 (low molecular weight protein antigen 2) (CFP-2), at 2,655,609 to 2,656,115 Rv2376c Rv2377c: Rv2377c - Putative conserved protein MbtH, at 2,656,215 to 2,656,430 Rv2377c Rv2378c: Rv2378c - Lysine-N-oxygenase MbtG (L-lysine 6-monooxygenase) (lysine N6-hydroxylase), at 2,656,408 to 2,657,703 Rv2378c Rv2379c: Rv2379c - Peptide synthetase MbtF (peptide synthase), at 2,657,700 to 2,662,085 Rv2379c
Group Condition Rv2375 Rv2376c Rv2377c Rv2378c Rv2379c
nitrogen source L-Alanine 10 mM (N) -0.0 -3.0 -0.2 -0.7 -0.1
stress 7H9 with Isoniazid 0.025 ug/mL -0.2 -1.1 -0.1 -0.3 -0.7
carbon source Glycerol (C) -0.6 -1.5 -0.5 +0.2 -0.1
nitrogen source L-Asparagine 10 mM (N) -0.4 -0.9 +0.0 -0.4 -0.4
stress 7H9 with Isoniazid 0.025 ug/mL -0.4 -0.8 +0.5 -1.3 +0.1
carbon source Valeric 10 mM (C) -0.0 -0.5 -0.3 -0.6 -0.5
carbon source butyrate 10 mM (C) -0.2 -1.0 +0.2 -0.4 -0.4
nitrogen source L-Glutamic 10 mM (N) -0.2 -1.1 +0.3 -0.4 -0.4
carbon source casaminos 1 mg/mL (C) -0.4 -1.3 -0.1 +0.1 +0.0
stress 7H9 with para-aminosalicylic 0.086 ug/mL -0.1 -0.7 -0.8 +0.3 +0.1
no stress control no stress control +0.1 -0.4 -1.1 +0.4 -0.2
carbon source D-Trehalose 10 mM (C) -0.3 -0.8 +0.1 +0.4 -0.3
stress 7H9 with Levofloxacin 0.3 ug/mL -0.3 -0.4 +0.3 -1.1 +0.4
stress 7H9 with Bedaquiline 0.15 ug/mL -0.3 +0.5 -0.7 -0.1 -0.4
carbon source D,L-Malic Acid 10 mM (C) -0.0 -1.2 +0.1 +0.5 -0.4
stress 7H9 with Pretomanid 0.213 ug/mL -0.2 -0.5 -0.7 +0.9 -0.3
nitrogen source L-Serine 10 mM (N) -0.1 +0.7 -0.3 -0.7 -0.4
carbon source Palmitic 100 uM (C) -0.0 -1.2 +0.0 -0.1 +0.5
nitrogen source L-Asparagine 10 mM (N) -0.2 +1.0 -0.8 -0.1 -0.5
stress 7H9 with Moxifloxacin 0.121 ug/mL -0.0 -0.1 -0.7 -0.4 +0.7
stress 7H9 with Meropenem 9.6 ug/mL -0.4 -0.6 +0.7 +0.1 -0.2
stress 7H9 with Clofazimine 0.072 ug/mL -0.2 +0.3 -0.9 +0.8 -0.3
stress 7H9 with Meropenem 9.6 ug/mL -0.2 -0.8 +0.2 +0.6 -0.0
carbon source Valeric 10 mM (C) +0.1 -0.7 +0.4 +0.5 -0.3
stress 7H9 with Ethambutol 0.75 ug/mL -0.4 -0.2 +0.4 +0.9 -0.6
stress 7H9 with Rifampicin 0.00045 ug/mL -0.4 +0.2 -0.1 +1.1 -0.4
stress 7H9 with Sulfaquinoxaline 0.097 mM +0.2 -0.6 +0.1 +0.8 +0.2
stress 7H9 with Rifampicin 0.014 ug/mL -0.0 +0.9 -0.3 +0.5 -0.3
nitrogen source L-Valine 10 mM (N) +0.0 +1.3 -0.7 +0.3 +0.1
stress 7H9 with Linezolid 0.44 ug/mL -0.1 +1.1 +0.1 +0.5 -0.1
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