Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv2373c and Rv2374c are separated by 74 nucleotidesRv2374c and Rv2375 are separated by 171 nucleotidesRv2375 and Rv2376c are separated by 26 nucleotidesRv2376c and Rv2377c are separated by 99 nucleotides Rv2373c: Rv2373c - Probable chaperone protein DnaJ2, at 2,652,839 to 2,653,987 Rv2373c Rv2374c: Rv2374c - Probable heat shock protein transcriptional repressor HrcA, at 2,654,062 to 2,655,093 Rv2374c Rv2375: Rv2375 - Conserved hypothetical protein, at 2,655,265 to 2,655,582 Rv2375 Rv2376c: Rv2376c - Low molecular weight antigen CFP2 (low molecular weight protein antigen 2) (CFP-2), at 2,655,609 to 2,656,115 Rv2376c Rv2377c: Rv2377c - Putative conserved protein MbtH, at 2,656,215 to 2,656,430 Rv2377c
Group Condition Rv2373c Rv2374c Rv2375 Rv2376c Rv2377c
stress 7H9 with Dodecyl Sulfate 0.02 vol% N.D. -2.9 -0.1 -1.1 +0.2
nitrogen source L-Alanine 10 mM (N) N.D. -0.5 -0.0 -3.0 -0.2
carbon source casaminos 1 mg/mL (C) N.D. -1.5 -0.4 -1.3 -0.1
no stress control no stress control N.D. -1.1 -0.2 -1.3 -0.5
stress 7H9 with Hydrogen peroxide 2.5 mM; pH 5.5 N.D. -1.7 +0.0 -1.8 +0.4
stress 7H9 with Sutezolid 0.12 ug/mL N.D. -2.1 +0.2 -1.0 -0.1
stress 7H9 with Pyrazinamide 50 ug/mL; pH 5.5 N.D. -0.6 -0.5 -1.4 -0.4
stress 7H9 with nitrite 3 mM; pH 5.5 N.D. -1.0 -0.1 -1.0 -0.7
no stress control no stress control N.D. -1.2 +0.1 -0.4 -1.1
stress 7H9 with Linezolid 0.3 ug/mL N.D. -1.3 -0.3 -1.2 +0.2
stress 7H9 with Chloramphenicol 0.01 mM N.D. -0.3 -0.3 -2.0 +0.2
stress 7H9 with 8-hydroxy-nitroquinoline 0.03 mM N.D. -1.9 -0.3 +0.7 -0.9
stress 7H9 with Hydrogen peroxide 2.5 mM; pH 6.5 N.D. -1.2 -0.0 -1.8 +0.7
stress 7H9 with Isoniazid 0.025 ug/mL N.D. -1.6 -0.4 -0.8 +0.5
carbon source Glycerol (C) N.D. +0.3 -0.6 -1.5 -0.5
stress 7H9 with Dicloxacillin 0.0069 mM N.D. -2.4 -0.2 -0.0 +0.5
no stress control no stress control N.D. -1.6 -0.2 -0.8 +0.5
stress 7H9 with Chloramphenicol 0.01 mM N.D. -1.2 -0.4 -1.2 +0.8
no stress control no stress control N.D. -2.9 +0.1 +0.8 +0.1
stress 7H9 with Cumene hydroperoxide 0.05 mM N.D. -0.6 -0.1 -1.7 +0.6
stress 7H9 with Amikacin di2 ug/mL N.D. -1.9 -0.1 +0.5 -0.5
stress 7H9 with 8-hydroxy-nitroquinoline 0.03 mM N.D. -1.7 -0.1 +1.1 -1.0
stress 7H9 with Meropenem 9.6 ug/mL N.D. -1.4 -0.4 -0.6 +0.7
stress 7H9 with Erythromycin 0.016 mM N.D. -0.3 +0.0 -2.1 +0.7
stress 7H9 with Hydrogen peroxide 2.5 mM; pH 5.5 N.D. -2.1 -0.2 +0.6 +0.5
stress 7H9 with Phenazine methosulfate 0.0054 mM N.D. -1.1 -0.3 +0.8 -0.7
stress 7H9 with Dibucaine 0.21 mM N.D. +0.6 -0.5 +0.5 -1.5
stress 7H9 with Vancomycin Hydrochloride from Streptomyces orientalis 0.012 mM N.D. -1.1 -0.0 +1.8 -0.9
stress 7H9 with nitrite 1.5 mM; pH 5.5 N.D. -0.5 -0.6 +1.8 +0.1
stress 7H9 with Norfloxacin 0.125 mM N.D. -1.1 -0.2 +2.2 +0.5
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