Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv2341 and Rv2342 are separated by 255 nucleotidesRv2342 and Rv2343c are separated by 3 nucleotidesRv2343c and Rv2344c are separated by 4 nucleotidesRv2344c and Rv2345 are separated by 68 nucleotides Rv2341: Rv2341 - Probable conserved lipoprotein LppQ, at 2,619,597 to 2,620,016 Rv2341 Rv2342: Rv2342 - Conserved hypothetical protein, at 2,620,272 to 2,620,529 Rv2342 Rv2343c: Rv2343c - Probable DNA primase DnaG, at 2,620,533 to 2,622,452 Rv2343c Rv2344c: Rv2344c - Probable deoxyguanosine triphosphate triphosphohydrolase Dgt (dGTPase) (dGTP triphosphohydrolase), at 2,622,457 to 2,623,752 Rv2344c Rv2345: Rv2345 - Possible conserved transmembrane protein, at 2,623,821 to 2,625,803 Rv2345
Group Condition Rv2341 Rv2342 Rv2343c Rv2344c Rv2345
no stress control no stress control -0.5 -0.9 N.D. -1.0 +0.0
stress 7H9 with Hydrogen peroxide 3.97 mM -0.3 -0.6 N.D. -1.0 -0.1
stress 7H9 with Menadione 0.005 mM -0.3 -0.8 N.D. -0.8 +0.0
stress 7H9 with Hydrogen peroxide 2.5 mM; pH 5.5 +0.1 -0.8 N.D. -1.0 -0.1
stress 7H9 with Isoniazid 0.025 ug/mL -0.0 -1.0 N.D. -0.6 -0.2
no stress control no stress control -0.4 -0.8 N.D. -0.7 +0.1
stress 7H9 with Phenazine methosulfate 0.0054 mM -0.1 -0.5 N.D. -1.1 -0.0
stress 7H9 with Hydrogen peroxide 2.5 mM; pH 6.5 -0.3 -0.5 N.D. -0.7 -0.1
no stress control no stress control -0.2 -0.7 N.D. -0.7 +0.0
stress 7H9 with 2,4-Dinitrophenol 0.1503 mM -0.1 -0.5 N.D. -1.1 +0.0
stress 7H9 with 2-Mercaptopyridine N-oxide 0.0078 mM +0.1 +0.1 N.D. -1.7 +0.0
stress 7H9 with Ethionamide 0.1 ug/mL -0.1 -1.0 N.D. -0.5 +0.2
stress 7H9 with Hydrogen peroxide 3.97 mM -0.1 -0.2 N.D. -1.1 -0.0
carbon source butyrate 10 mM (C) -0.2 -0.8 N.D. -0.5 +0.0
no stress control no stress control +0.0 -0.4 N.D. -0.9 -0.0
stress 7H9 with Amikacin di2 ug/mL -0.2 -0.4 N.D. -0.7 -0.0
stress 7H9 with nitrite 1.5 mM; pH 5.5 -0.2 -0.4 N.D. -0.6 -0.1
stress 7H9 with nitrite 1.5 mM; pH 5.5 +0.0 -0.5 N.D. -0.9 +0.1
no stress control no stress control -0.1 -0.7 N.D. -0.6 +0.1
no stress control no stress control -0.1 -0.6 N.D. -0.7 +0.2
stress 7H9 with Hydrogen peroxide 2.5 mM; pH 5.5 +0.0 -0.4 N.D. -0.8 -0.1
no stress control no stress control +0.1 -0.6 N.D. -0.7 -0.1
stress 7H9 with Amikacin di2 ug/mL +0.2 -0.8 N.D. -0.7 +0.1
stress 7H9 with Doxycycline hyclate 0.0035 mM +0.1 -0.6 N.D. -0.7 +0.1
stress 7H9 with 2-Mercaptopyridine N-oxide 0.0078 mM +0.2 -0.1 N.D. -1.1 -0.1
stress 7H9 with Ethionamide 0.1 ug/mL -0.2 -1.0 N.D. +0.1 +0.1
stress 7H9 with 2,4-Dinitrophenol 0.1503 mM +0.2 -0.2 N.D. -1.0 +0.1
stress 7H9 with Moxifloxacin 0.121 ug/mL -0.1 -0.6 N.D. -0.5 +0.2
stress 7H9 with 8-hydroxy-nitroquinoline 0.03 mM +0.3 -0.2 N.D. -1.0 -0.0
pH pH 4.5 +0.2 -1.0 N.D. +0.4 -0.1
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