Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv2318 and Rv2319c are separated by 7 nucleotidesRv2319c and Rv2320c overlap by 4 nucleotidesRv2320c and Rv2321c are separated by 0 nucleotidesRv2321c and Rv2322c overlap by 1 nucleotides Rv2318: Rv2318 - Probable periplasmic sugar-binding lipoprotein UspC, at 2,590,518 to 2,591,840 Rv2318 Rv2319c: Rv2319c - Universal stress protein family protein, at 2,591,848 to 2,592,726 Rv2319c Rv2320c: Rv2320c - Probable cationic amino acid transport integral membrane protein RocE, at 2,592,723 to 2,594,153 Rv2320c Rv2321c: Rv2321c - Probable ornithine aminotransferase (C-terminus part) RocD2 (ornithine--oxo-acid aminotransferase), at 2,594,154 to 2,594,699 Rv2321c Rv2322c: Rv2322c - Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase), at 2,594,699 to 2,595,364 Rv2322c
Group Condition Rv2318 Rv2319c Rv2320c Rv2321c Rv2322c
carbon source Palmitic 100 uM (C) -0.0 -0.1 +0.0 -0.8 -0.5
stress 7H9 with Delamanid 0.236 ug/mL +0.2 -0.3 +0.2 -0.6 -0.7
stress 7H9 with Ethambutol 0.75 ug/mL -0.3 +0.3 +0.0 -1.1 +0.1
carbon source Stearic 100 uM (C) -0.2 +0.4 -0.0 -0.7 -0.4
stress 7H9 with Hygromycin B 0.0095 mM +0.3 -0.6 +0.0 +0.0 -0.6
stress 7H9 with Bedaquiline 0.15 ug/mL +0.3 -0.0 +0.1 -0.8 -0.3
carbon source casaminos 1 mg/mL (C) -0.5 +0.5 +0.1 -0.4 -0.5
stress 7H9 with Rifampicin 0.00045 ug/mL +0.1 -0.0 +0.3 -1.8 +0.9
carbon source L-Lactate 10 mM (C) -0.0 +0.5 -0.2 -0.4 -0.4
stress 7H9 with Linezolid 0.44 ug/mL -0.1 +0.4 +0.0 -1.1 +0.2
stress 7H9 with Levofloxacin 0.3 ug/mL +0.1 +0.2 -0.4 +0.4 -0.8
nitrogen source L-Valine 10 mM (N) -0.3 +0.5 -0.1 +0.2 -0.4
no stress control no stress control +0.1 +0.6 +0.1 -0.5 -0.2
carbon source D,L-Malic Acid 10 mM (C) +0.2 +0.7 -0.1 -0.9 +0.3
carbon source L-Lactate 10 mM (C) +0.2 +0.8 +0.0 -0.5 +0.1
carbon source D-Trehalose 10 mM (C) +0.1 +0.2 -0.0 -0.5 +0.8
nitrogen source L-Serine 10 mM (N) -0.2 +0.5 +0.1 +0.8 -0.2
stress 7H9 with Rifampicin 0.014 ug/mL +0.4 +0.3 +0.1 -0.3 +0.5
nitrogen source L-Glutamic 10 mM (N) -0.2 +0.1 -0.2 +0.8 +0.4
carbon source D-Lactate 10 mM (C) +0.1 +0.7 +0.0 -0.3 +0.5
nitrogen source L-Alanine 10 mM (N) -0.4 +0.6 +0.1 +0.4 +0.4
stress 7H9 with Ofloxacin 0.8 ug/mL +0.6 +0.5 -0.1 -0.2 +0.6
stress 7H9 with Moxifloxacin 0.121 ug/mL +0.3 +0.5 -0.2 +0.2 +0.6
stress 7H9 with Moxifloxacin 0.121 ug/mL +0.5 +0.4 -0.0 +0.0 +0.6
nitrogen source L-Aspartic Acid 10 mM (N) +0.2 +0.4 +0.1 +0.7 +0.3
carbon source Glycerol (C) +0.4 +0.5 +0.1 +0.2 +0.5
carbon source Glycerol (C) +0.4 +0.4 -0.0 +0.2 +0.5
stress 7H9 with para-aminosalicylic 0.086 ug/mL +0.7 +0.2 +0.1 +0.5 +0.5
carbon source D,L-Malic Acid 10 mM (C) +0.2 +1.0 +0.1 +0.0 +0.7
no stress control no stress control +0.6 +0.0 -0.0 +1.3 +0.3
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