Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv2239c and Rv2240c are separated by 37 nucleotidesRv2240c and Rv2241 are separated by 258 nucleotidesRv2241 and Rv2242 are separated by 59 nucleotidesRv2242 and Rv2243 are separated by 238 nucleotides Rv2239c: Rv2239c - Conserved hypothetical protein, at 2,511,176 to 2,511,652 Rv2239c Rv2240c: Rv2240c - Unknown protein, at 2,511,690 to 2,512,280 Rv2240c Rv2241: Rv2241 - Pyruvate dehydrogenase E1 component AceE (pyruvate decarboxylase) (pyruvate dehydrogenase) (pyruvic dehydrogenase), at 2,512,539 to 2,515,244 Rv2241 Rv2242: Rv2242 - Conserved hypothetical protein, at 2,515,304 to 2,516,548 Rv2242 Rv2243: Rv2243 - Malonyl CoA-acyl carrier protein transacylase FabD (malonyl CoA:ACPM acyltransferase) (MCT), at 2,516,787 to 2,517,695 Rv2243
Group Condition Rv2239c Rv2240c Rv2241 Rv2242 Rv2243
stress 7H9 with Phenazine ethosulfate 0.0137 mM N.D. -2.8 N.D. N.D. N.D.
stress 7H9 with Vancomycin Hydrochloride from Streptomyces orientalis 0.012 mM N.D. -2.5 N.D. N.D. N.D.
stress 7H9 with Clofazimine 0.072 ug/mL N.D. -2.3 N.D. N.D. N.D.
stress 7H9 with 2,4-Dinitrophenol 0.1503 mM N.D. -2.1 N.D. N.D. N.D.
stress 7H9 with Hydrogen peroxide 2.5 mM; pH 5.5 N.D. -1.7 N.D. N.D. N.D.
stress 7H9 with Cloxacillin 0.0386 mM N.D. -1.5 N.D. N.D. N.D.
nitrogen source L-Asparagine 10 mM (N) N.D. -1.5 N.D. N.D. N.D.
nitrogen source L-Glutamine 10 mM (N) N.D. -1.4 N.D. N.D. N.D.
stress 7H9 with Tetrazolium violet 0.065 mM N.D. -1.4 N.D. N.D. N.D.
stress 7H9 with Delamanid 0.236 ug/mL N.D. -1.3 N.D. N.D. N.D.
stress 7H9 with nitrite 1.5 mM; pH 5.5 N.D. -1.3 N.D. N.D. N.D.
no stress control no stress control N.D. -1.2 N.D. N.D. N.D.
stress 7H9 with Ethionamide 0.1 ug/mL N.D. -1.2 N.D. N.D. N.D.
stress 7H9 with Clarithromycin 0.967 ug/mL N.D. -1.2 N.D. N.D. N.D.
nitrogen source L-Asparagine 10 mM (N) N.D. -1.2 N.D. N.D. N.D.
stress 7H9 with Phenazine methosulfate 0.0054 mM N.D. -1.2 N.D. N.D. N.D.
nitrogen source L-Aspartic Acid 10 mM (N) N.D. -1.2 N.D. N.D. N.D.
stress 7H9 with Malondialdehyde tetrabutylammonium salt 0.96 mM N.D. -1.1 N.D. N.D. N.D.
stress 7H9 with Doxycycline hyclate 0.0035 mM N.D. -1.1 N.D. N.D. N.D.
stress 7H9 with Clofazimine 0.45 ug/mL N.D. -1.0 N.D. N.D. N.D.
no stress control no stress control N.D. +1.0 N.D. N.D. N.D.
stress 7H9 with Ciprofloxacin Hydrochloride 0.0012 mM N.D. +1.1 N.D. N.D. N.D.
stress 7H9 with Geneticin G418 0.35 mM N.D. +1.1 N.D. N.D. N.D.
pH 7H9 pH 5.5 N.D. +1.2 N.D. N.D. N.D.
nitrogen source Urea 10mM (N) N.D. +1.2 N.D. N.D. N.D.
stress 7H9 with Ofloxacin 0.8 ug/mL N.D. +1.3 N.D. N.D. N.D.
carbon source cholesterol 100uM (C) N.D. +1.3 N.D. N.D. N.D.
stress 7H9 with Ciprofloxacin Hydrochloride 0.001 mM N.D. +1.3 N.D. N.D. N.D.
carbon source cholesterol 100uM (C) N.D. +1.8 N.D. N.D. N.D.
stress 7H9 with Levofloxacin 0.3 ug/mL N.D. +2.0 N.D. N.D. N.D.
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