Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv2207 and Rv2208 overlap by 4 nucleotidesRv2208 and Rv2209 are separated by 157 nucleotidesRv2209 and Rv2210c overlap by 75 nucleotidesRv2210c and Rv2211c are separated by 71 nucleotides Rv2207: Rv2207 - Probable nicotinate-nucleotide-dimethylbenzimidazol phosphoribosyltransferase CobT, at 2,471,411 to 2,472,496 Rv2207 Rv2208: Rv2208 - Probable cobalamin 5'-phosphate synthase CobS, at 2,472,493 to 2,473,242 Rv2208 Rv2209: Rv2209 - Probable conserved integral membrane protein, at 2,473,400 to 2,474,938 Rv2209 Rv2210c: Rv2210c - Branched-chain amino acid transaminase IlvE, at 2,474,864 to 2,475,970 Rv2210c Rv2211c: Rv2211c - Probable aminomethyltransferase GcvT (glycine cleavage system T protein), at 2,476,042 to 2,477,181 Rv2211c
Group Condition Rv2207 Rv2208 Rv2209 Rv2210c Rv2211c
stress 7H9 with copper (II) chloride 0.08 mM N.D. -0.8 -0.4 N.D. N.D.
stress 7H9 with Novobiocin 0.004 mM N.D. -0.8 -0.3 N.D. N.D.
pH pH 5.5 N.D. -0.9 +0.0 N.D. N.D.
stress 7H9 with Antimycin A 0.0186 mM N.D. -0.8 -0.1 N.D. N.D.
carbon source Valeric 10 mM (C) N.D. -0.7 -0.1 N.D. N.D.
stress 7H9 with Ethambutol 0.75 ug/mL N.D. -0.8 +0.0 N.D. N.D.
stress 7H9 with Rifampicin 0.014 ug/mL N.D. -0.8 +0.1 N.D. N.D.
stress 7H9 with Ciprofloxacin Hydrochloride 0.0012 mM N.D. -0.7 +0.1 N.D. N.D.
carbon source Stearic 100 uM (C) N.D. -0.5 -0.2 N.D. N.D.
stress 7H9 with Lomefloxacin 0.0035 mM N.D. -0.5 -0.1 N.D. N.D.
stress 7H9 with Amikacin di2 ug/mL N.D. -0.7 +0.1 N.D. N.D.
stress 7H9 with Cloxacillin 0.0386 mM N.D. -0.5 -0.2 N.D. N.D.
stress 7H9 with Ceftriaxone hemi(heptahydrate) 0.12 mM N.D. -0.6 -0.1 N.D. N.D.
stress 7H9 with Cumene hydroperoxide 0.05 mM N.D. -0.5 -0.1 N.D. N.D.
carbon source butyrate 10 mM (C) N.D. -0.4 -0.2 N.D. N.D.
no stress control no stress control N.D. -0.5 -0.1 N.D. N.D.
carbon source cholesterol 100uM (C) N.D. -0.6 -0.0 N.D. N.D.
stress 7H9 with Phenazine methosulfate 0.0054 mM N.D. -0.6 +0.1 N.D. N.D.
no stress control no stress control N.D. -0.7 +0.1 N.D. N.D.
stress 7H9 with Ethambutol 0.75 ug/mL N.D. -0.6 +0.0 N.D. N.D.
stress 7H9 with Sutezolid 0.12 ug/mL N.D. -0.4 +0.2 N.D. N.D.
stress 7H9 with Ethionamide 0.1 ug/mL N.D. +0.4 -0.3 N.D. N.D.
stress 7H9 with Lomefloxacin 0.0035 mM N.D. +0.4 -0.3 N.D. N.D.
stress 7H9 with Ramoplanin 0.009 mM N.D. +0.4 -0.2 N.D. N.D.
stress 7H9 with Delamanid 0.236 ug/mL N.D. +0.5 -0.1 N.D. N.D.
stress 7H9 with Moxifloxacin 0.121 ug/mL N.D. +0.7 -0.2 N.D. N.D.
stress 7H9 with Delamanid 0.236 ug/mL N.D. +0.6 -0.0 N.D. N.D.
no stress control no stress control N.D. +0.7 +0.0 N.D. N.D.
stress 7H9 with Isoniazid 0.025 ug/mL N.D. +0.5 +0.3 N.D. N.D.
stress 7H9 with Ofloxacin 0.8 ug/mL N.D. +0.7 +0.1 N.D. N.D.
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