Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv2141c and GFF2219 are separated by 264 nucleotidesGFF2219 and Rv2142c are separated by 120 nucleotidesRv2142c and Rv2142A overlap by 4 nucleotidesRv2142A and Rv2143 are separated by 254 nucleotides Rv2141c: Rv2141c - Conserved protein, at 2,400,376 to 2,401,722 Rv2141c GFF2219 - tRNA-Leu, at 2,401,987 to 2,402,072 GFF2219 Rv2142c: Rv2142c - Possible toxin ParE2, at 2,402,193 to 2,402,510 Rv2142c Rv2142A: Rv2142A - Possible antitoxin ParD2, at 2,402,507 to 2,402,722 Rv2142A Rv2143: Rv2143 - Conserved hypothetical protein, at 2,402,977 to 2,404,035 Rv2143
Group Condition Rv2141c GFF2219 Rv2142c Rv2142A Rv2143
nitrogen source L-Alanine 10 mM (N) -0.4 N.D. -0.1 N.D. -0.2
stress 7H9 with 2-Mercaptopyridine N-oxide 0.0078 mM -0.8 N.D. +0.0 N.D. +0.1
stress 7H9 with nitrate 4 mM -0.4 N.D. +0.1 N.D. -0.2
stress 7H9 with Irgasan 0.065 mM -0.4 N.D. -0.0 N.D. +0.2
pH 7H9 pH 5.5 -0.4 N.D. +0.2 N.D. -0.0
stress 7H9 with Hydrogen peroxide 2.5 mM; pH 5.5 -0.3 N.D. +0.3 N.D. -0.1
stress 7H9 with Irgasan 0.065 mM +0.3 N.D. -0.2 N.D. -0.1
stress 7H9 with Phenazine methosulfate 0.0054 mM -0.1 N.D. -0.3 N.D. +0.3
stress 7H9 with 2-Mercaptopyridine N-oxide 0.0078 mM -0.4 N.D. +0.2 N.D. +0.2
stress 7H9 with Nickel (II) chloride 0.6 mM +0.2 N.D. -0.3 N.D. +0.2
nitrogen source Urea 10mM (N) -0.1 N.D. +0.4 N.D. -0.2
stress 7H9 with nitrite 2.5 mM -0.3 N.D. +0.4 N.D. +0.1
pH pH 4.5 -0.3 N.D. +0.5 N.D. -0.0
stress 7H9 with Malondialdehyde tetrabutylammonium salt 0.96 mM +0.5 N.D. -0.2 N.D. +0.0
stress 7H9 with nitrite 1.5 mM; pH 5.5 -0.3 N.D. +0.6 N.D. +0.1
stress 7H9 with 2-bromo-2-nitro-1,3-propanediol 0.1 mM -0.2 N.D. +0.4 N.D. +0.1
stress 7H9 with Sisomicin 0.07 mM -0.3 N.D. +0.6 N.D. +0.1
no stress control no stress control -0.2 N.D. +0.6 N.D. +0.0
stress 7H9 with Malondialdehyde tetrabutylammonium salt 0.96 mM +0.6 N.D. -0.2 N.D. +0.1
stress 7H9 with Thioridazine 0.028 mM +0.1 N.D. +0.2 N.D. +0.4
stress 7H9 with Menadione 0.005 mM +0.6 N.D. +0.0 N.D. +0.1
stress 7H9 with Chlorhexidine diacetate salt 0.0021 mM +0.0 N.D. +0.2 N.D. +0.5
stress 7H9 with Ethionamide 0.1 ug/mL +0.5 N.D. -0.1 N.D. +0.4
stress 7H9 with Cloxacillin 0.0386 mM +0.1 N.D. +0.4 N.D. +0.2
stress 7H9 with para-aminosalicylic 0.086 ug/mL +0.1 N.D. +0.1 N.D. +0.6
stress 7H9 with Ethionamide 0.1 ug/mL +0.5 N.D. +0.1 N.D. +0.2
stress 7H9 with Isoniazid 0.025 ug/mL +0.5 N.D. +0.2 N.D. +0.2
stress 7H9 with Ofloxacin 0.8 ug/mL +0.2 N.D. +0.4 N.D. +0.3
stress 7H9 with Moxifloxacin 0.121 ug/mL +0.5 N.D. +0.1 N.D. +0.4
no stress control no stress control +0.3 N.D. +0.7 N.D. +0.0
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