Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv2116 and Rv2117 are separated by 7 nucleotidesRv2117 and Rv2118c are separated by 28 nucleotidesRv2118c and Rv2119 are separated by 73 nucleotidesRv2119 and Rv2120c are separated by 22 nucleotides Rv2116: Rv2116 - Conserved lipoprotein LppK, at 2,376,571 to 2,377,140 Rv2116 Rv2117: Rv2117 - Conserved hypothetical protein, at 2,377,148 to 2,377,441 Rv2117 Rv2118c: Rv2118c - RNA methyltransferase, at 2,377,470 to 2,378,312 Rv2118c Rv2119: Rv2119 - Conserved hypothetical protein, at 2,378,386 to 2,379,222 Rv2119 Rv2120c: Rv2120c - Probable conserved integral membrane protein, at 2,379,245 to 2,379,727 Rv2120c
Group Condition Rv2116 Rv2117 Rv2118c Rv2119 Rv2120c
stress 7H9 with 2-bromo-2-nitro-1,3-propanediol 0.1 mM -0.3 N.D. -0.3 -0.3 -0.5
stress 7H9 with Levofloxacin 0.3 ug/mL -1.0 N.D. +0.0 -0.1 -0.3
stress 7H9 with Malondialdehyde tetrabutylammonium salt 0.96 mM -0.4 N.D. -0.4 -0.2 -0.3
carbon source L-Asparagine (C) -0.6 N.D. -0.3 -0.2 -0.0
no stress control no stress control -0.6 N.D. -0.3 -0.0 -0.2
stress 7H9 with Levofloxacin 0.3 ug/mL +0.2 N.D. +0.1 -0.3 -0.6
stress 7H9 with Hydrogen peroxide 3.97 mM -0.4 N.D. -0.1 -0.2 +0.3
stress 7H9 with Levofloxacin 0.3 ug/mL -0.4 N.D. -0.2 -0.2 +0.3
stress 7H9 with Menadione 0.005 mM -0.4 N.D. +0.1 +0.3 -0.4
stress 7H9 with Moxifloxacin 0.121 ug/mL +0.4 N.D. +0.1 -0.3 -0.3
stress 7H9 with Ethionamide 0.1 ug/mL +0.4 N.D. +0.2 -0.1 -0.7
stress 7H9 with Hydrogen peroxide 2.5 mM; pH 6.5 +0.5 N.D. -0.2 -0.1 -0.3
stress 7H9 with Cumene hydroperoxide 0.05 mM -0.3 N.D. -0.2 -0.1 +0.5
stress 7H9 with Sisomicin 0.07 mM -0.4 N.D. +0.4 -0.2 +0.3
carbon source Stearic 100 uM (C) -0.5 N.D. +0.4 +0.0 +0.2
nitrogen source Ammonium chloride 10mM (N) +0.6 N.D. +0.1 -0.1 -0.3
stress 7H9 with nitrite 3 mM; pH 5.5 +0.8 N.D. -0.1 +0.0 -0.3
pH 7H9 pH 5.5 +0.2 N.D. -0.3 -0.1 +0.6
stress 7H9 with Ceftriaxone hemi(heptahydrate) 0.12 mM +0.4 N.D. +0.2 +0.2 -0.4
stress 7H9 with Hydrogen peroxide 2.5 mM; pH 5.5 +0.5 N.D. -0.3 +0.3 -0.1
stress 7H9 with Linezolid 0.44 ug/mL -0.3 N.D. +0.3 +0.0 +0.6
stress 7H9 with Sisomicin 0.07 mM +0.3 N.D. +0.2 +0.2 -0.2
nitrogen source L-Valine 10 mM (N) +0.3 N.D. +0.1 -0.2 +0.5
stress 7H9 with Ofloxacin 0.8 ug/mL +0.1 N.D. +0.4 -0.2 +0.3
stress 7H9 with Ciprofloxacin Hydrochloride 0.001 mM -0.2 N.D. +0.4 +0.2 +0.3
no stress control no stress control +0.9 N.D. +0.1 -0.1 +0.0
stress 7H9 with Doxycycline hyclate 0.0035 mM -0.0 N.D. +0.1 -0.1 +1.0
stress 7H9 with Novobiocin 0.004 mM +0.7 N.D. +0.3 +0.2 -0.2
carbon source cholesterol 100uM (C) +0.7 N.D. +0.2 +0.0 +0.3
carbon source cholesterol 100uM (C) +1.0 N.D. +0.3 +0.4 +0.2
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