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Fitness for 5 genes in
Mycobacterium tuberculosis H37Rv
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Top 30 experiments (either direction), sorted by average fitness
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500 nt
Rv2089c and Rv2090 are separated by 48 nucleotides
Rv2090 and Rv2091c are separated by 3 nucleotides
Rv2091c and Rv2092c are separated by 41 nucleotides
Rv2092c and Rv2093c are separated by 48 nucleotides
Rv2089c: Rv2089c - Dipeptidase PepE, at 2,346,197 to 2,347,324
Rv2089c
Rv2090: Rv2090 - Probable 5'-3' exonuclease, at 2,347,373 to 2,348,554
Rv2090
Rv2091c: Rv2091c - Probable membrane protein, at 2,348,558 to 2,349,292
Rv2091c
Rv2092c: Rv2092c - ATP-dependent DNA helicase HelY, at 2,349,334 to 2,352,054
Rv2092c
Rv2093c: Rv2093c - Sec-independent protein translocase transmembrane protein TatC, at 2,352,103 to 2,353,029
Rv2093c
Group
Condition
Rv2089c
Rv2090
Rv2091c
Rv2092c
Rv2093c
carbon source
acetate (C)
-1.4
+0.1
-0.3
-0.3
N.D.
stress
7H9 with Rifampicin 0.014 ug/mL
-0.0
-0.3
-1.6
+0.1
N.D.
stress
7H9 with Rifampicin 0.00045 ug/mL
+0.0
-0.3
-1.4
+0.1
N.D.
stress
7H9 with Rifampicin 0.014 ug/mL
+0.3
-0.4
-1.6
+0.2
N.D.
nitrogen source
L-Glutamic 10 mM (N)
-0.7
-0.2
-0.5
-0.0
N.D.
stress
7H9 with Bedaquiline 0.15 ug/mL
-0.1
-0.1
-1.1
-0.0
N.D.
nitrogen source
L-Asparagine 10 mM (N)
-0.5
-0.0
-0.9
+0.1
N.D.
stress
7H9 with Bedaquiline 0.15 ug/mL
+0.1
-0.2
-1.2
+0.0
N.D.
carbon source
D-Trehalose 10 mM (C)
-0.2
+0.1
-1.1
+0.1
N.D.
stress
7H9 with Clarithromycin 0.967 ug/mL
-0.4
+0.2
-0.5
-0.5
N.D.
nitrogen source
L-Alanine 10 mM (N)
-0.0
-0.2
-1.0
+0.1
N.D.
stress
7H9 with Hygromycin B 0.0095 mM
-0.7
-0.5
+0.1
+0.1
N.D.
carbon source
D-Glucose (C)
-0.2
+0.1
-1.0
-0.0
N.D.
nitrogen source
L-Serine 10 mM (N)
+0.3
-0.4
-0.9
+0.0
N.D.
nitrogen source
L-Alanine 10 mM (N)
-0.3
+0.0
-0.9
+0.2
N.D.
carbon source
L-Aspartic Acid (C)
-0.4
+0.0
-0.6
+0.1
N.D.
stress
7H9 with Rifampicin 0.00045 ug/mL
+0.2
-0.2
-0.9
+0.1
N.D.
nitrogen source
Glycine 10 mM (N)
+0.2
+0.1
-1.1
+0.1
N.D.
nitrogen source
L-Asparagine 10 mM (N)
+0.3
-0.1
-1.0
+0.2
N.D.
stress
7H9 with Isoniazid 0.025 ug/mL
-0.7
+0.1
+0.3
-0.3
N.D.
nitrogen source
L-Serine 10 mM (N)
+0.3
+0.1
-0.9
+0.1
N.D.
carbon source
propionate (C)
-0.8
-0.1
+0.4
+0.2
N.D.
stress
7H9 with Isoniazid 0.025 ug/mL
-0.0
+0.3
+0.1
-0.7
N.D.
carbon source
D-Trehalose 10 mM (C)
+0.5
+0.1
-0.8
-0.1
N.D.
stress
7H9 with Ofloxacin 0.8 ug/mL
-0.6
+0.2
+0.3
+0.1
N.D.
stress
7H9 with Sulfamethizole 0.026 mM
-0.4
-0.1
+0.9
+0.2
N.D.
carbon source
L-Lactate 10 mM (C)
+0.6
+0.6
-0.7
-0.0
N.D.
stress
7H9 with Ethionamide 0.1 ug/mL
+0.1
+0.4
+0.5
-0.3
N.D.
stress
7H9 with Linezolid 0.44 ug/mL
+0.2
-0.2
+0.0
+0.8
N.D.
stress
7H9 with Sulfamethizole 0.026 mM
-0.2
+0.1
+1.1
+0.2
N.D.
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