Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv2063 and Rv2063A overlap by 8 nucleotidesRv2063A and Rv2064 overlap by 17 nucleotidesRv2064 and Rv2065 are separated by 9 nucleotidesRv2065 and Rv2066 overlap by 4 nucleotides Rv2063: Rv2063 - Antitoxin MazE7, at 2,320,831 to 2,321,064 Rv2063 Rv2063A: Rv2063A - Possible toxin MazF7, at 2,321,057 to 2,321,467 Rv2063A Rv2064: Rv2064 - Precorrin-3B synthase CobG, at 2,321,451 to 2,322,542 Rv2064 Rv2065: Rv2065 - Precorrin-8X methylmutase CobH (aka precorrin isomerase), at 2,322,552 to 2,323,178 Rv2065 Rv2066: Rv2066 - Probable bifunctional protein, CobI-COBJ fusion protein: S-adenosyl-L-methionine-precorrin-2 methyl transferase + precorrin-3 methylase, at 2,323,175 to 2,324,701 Rv2066
Group Condition Rv2063 Rv2063A Rv2064 Rv2065 Rv2066
stress 7H9 with copper (II) chloride 0.08 mM N.D. -0.5 -0.9 -1.0 -0.1
stress 7H9 with copper (II) chloride 0.08 mM N.D. -0.2 -1.1 -0.5 -0.2
stress 7H9 with Novobiocin 0.004 mM N.D. -0.4 -0.7 -0.7 -0.1
no stress control no stress control N.D. -1.0 -0.1 -0.5 +0.0
stress 7H9 with methylglyoxal 1.2 mM N.D. -0.7 -0.2 -0.6 -0.1
stress 7H9 with Dibucaine 0.21 mM N.D. -0.7 -0.4 -0.6 +0.1
carbon source D-Trehalose 10 mM (C) N.D. -0.5 -0.1 -1.0 +0.1
stress 7H9 with Chloramphenicol 0.01 mM N.D. -0.3 +0.1 -0.9 -0.1
stress 7H9 with Geneticin G418 0.35 mM N.D. -0.6 -0.5 -0.5 +0.3
stress 7H9 with Sisomicin 0.07 mM N.D. -0.2 -0.8 +0.7 +0.2
no stress control no stress control N.D. +0.4 -0.6 +0.8 -0.3
stress 7H9 with Erythromycin 0.016 mM N.D. +0.3 -0.6 +0.4 +0.0
carbon source Palmitic 100 uM (C) N.D. -0.6 +0.6 +0.3 -0.1
stress 7H9 with Ofloxacin 0.8 ug/mL N.D. +0.3 -0.5 +0.5 -0.1
stress 7H9 with Clarithromycin 0.967 ug/mL N.D. -0.2 -0.3 +0.8 +0.1
stress 7H9 with Hydrogen peroxide 2.5 mM; pH 6.5 N.D. +0.8 +0.1 -0.4 -0.2
stress 7H9 with Hygromycin B 0.0095 mM N.D. -0.0 -0.5 +1.0 +0.1
pH 7H9 pH 5.5 N.D. +0.3 -0.4 +0.6 +0.1
no stress control no stress control N.D. +0.4 -0.5 +0.8 +0.0
stress 7H9 with 2-bromo-2-nitro-1,3-propanediol 0.1 mM N.D. -0.1 -0.2 +1.1 +0.0
pH pH 5.5 N.D. -0.4 +0.9 +0.4 +0.1
stress 7H9 with Isoniazid 0.025 ug/mL N.D. +0.6 +0.1 +0.5 -0.3
stress 7H9 with Benzethonium chloride 0.068 mM N.D. +0.9 -0.3 +0.2 +0.2
stress 7H9 with Delamanid 0.236 ug/mL N.D. -0.2 +0.0 +1.1 +0.1
stress 7H9 with Cetrimonium bromide 0.015 vol% N.D. +1.0 -0.2 +0.2 +0.0
stress 7H9 with Isoniazid 0.025 ug/mL N.D. +0.7 -0.5 +1.2 -0.2
no stress control no stress control N.D. +0.4 +0.7 +0.2 -0.0
carbon source Valeric 10 mM (C) N.D. -0.1 +0.9 +0.6 +0.0
nitrogen source Ammonium chloride 10mM (N) N.D. +0.3 +0.7 +0.3 +0.2
stress 7H9 with Chlorhexidine diacetate salt 0.0021 mM N.D. +0.2 +0.5 +0.9 -0.0
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