Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv2024c and Rv2025c are separated by 509 nucleotidesRv2025c and Rv2026c are separated by 114 nucleotidesRv2026c and Rv2027c are separated by 39 nucleotidesRv2027c and Rv2028c are separated by 60 nucleotides Rv2024c: Rv2024c - Conserved hypothetical protein, at 2,268,693 to 2,270,240 Rv2024c Rv2025c: Rv2025c - Conserved membrane protein, at 2,270,750 to 2,271,748 Rv2025c Rv2026c: Rv2026c - Universal stress protein family protein, at 2,271,863 to 2,272,747 Rv2026c Rv2027c: Rv2027c - Two component sensor histidine kinase DosT, at 2,272,787 to 2,274,508 Rv2027c Rv2028c: Rv2028c - Universal stress protein family protein, at 2,274,569 to 2,275,408 Rv2028c
Group Condition Rv2024c Rv2025c Rv2026c Rv2027c Rv2028c
stress 7H9 with Isoniazid 0.025 ug/mL -0.2 -0.4 -1.6 -0.2 -1.1
no stress control no stress control -0.1 +0.1 -1.2 -0.0 -1.3
stress 7H9 with Isoniazid 0.025 ug/mL -0.1 +0.5 -1.9 -0.3 -0.5
stress 7H9 with Clofazimine 0.072 ug/mL -0.1 +0.1 -0.2 +0.1 -1.4
stress 7H9 with Ethambutol 0.75 ug/mL -0.0 +0.4 -0.2 +0.1 -1.4
stress 7H9 with Delamanid 0.236 ug/mL +0.1 -0.5 +0.3 -0.2 -0.7
stress 7H9 with Ofloxacin 0.8 ug/mL -0.5 +0.7 -0.1 +0.1 -0.5
carbon source Palmitic 100 uM (C) +0.0 -0.2 +0.5 +0.3 -0.8
no stress control no stress control -0.1 +1.0 -0.5 -0.4 +0.5
stress 7H9 with Ofloxacin 0.8 ug/mL -0.2 +0.1 -0.5 -0.1 +1.6
carbon source Valeric 10 mM (C) -0.1 -0.4 +0.3 +0.0 +0.9
stress 7H9 with Levofloxacin 0.3 ug/mL -0.3 +1.0 +0.1 -0.1 +0.1
stress 7H9 with Sulfamethizole 0.026 mM -0.1 -0.2 +0.8 +0.1 +0.5
carbon source Stearic 100 uM (C) +0.1 -0.3 +0.1 +0.1 +1.2
nitrogen source L-Serine 10 mM (N) +0.1 +0.0 +1.4 -0.1 -0.2
carbon source D-Lactate 10 mM (C) -0.2 -0.1 +0.8 +0.1 +0.6
stress 7H9 with Ethionamide 0.1 ug/mL -0.2 -0.2 +1.1 +0.0 +0.5
nitrogen source L-Asparagine 10 mM (N) -0.1 +0.5 +1.2 -0.0 -0.4
nitrogen source L-Serine 10 mM (N) +0.1 -0.1 +0.9 -0.0 +0.5
carbon source D-Lactate 10 mM (C) -0.1 +0.2 +0.9 +0.2 +0.4
carbon source L-Glutamine (C) +0.1 -0.1 +1.0 +0.2 +0.6
nitrogen source L-Alanine 10 mM (N) +0.0 +0.1 +1.3 -0.3 +0.7
nitrogen source L-Glutamine 10 mM (N) +0.0 +0.4 +0.7 -0.2 +0.8
stress 7H9 with Clofazimine 0.072 ug/mL +0.0 +0.5 +0.7 +0.1 +0.6
nitrogen source L-Alanine 10 mM (N) +0.0 +0.4 +1.1 -0.1 +0.7
nitrogen source Glycine 10 mM (N) +0.1 +0.2 +1.3 -0.1 +0.5
stress 7H9 with Moxifloxacin 0.121 ug/mL -0.4 +0.8 -0.1 -0.1 +1.9
nitrogen source L-Glutamic 10 mM (N) -0.2 -0.2 +1.0 -0.5 +2.0
nitrogen source L-Glutamic 10 mM (N) +0.2 +0.4 +1.2 -0.1 +0.5
nitrogen source L-Valine 10 mM (N) +0.3 +0.4 +1.7 +0.1 -0.0
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