Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv1999c and Rv2000 are separated by 70 nucleotidesRv2000 and Rv2001 are separated by 9 nucleotidesRv2001 and Rv2002 are separated by 75 nucleotidesRv2002 and Rv2003c are separated by 120 nucleotides Rv1999c: Rv1999c - Probable conserved integral membrane protein, at 2,243,816 to 2,245,138 Rv1999c Rv2000: Rv2000 - Unknown protein, at 2,245,209 to 2,246,822 Rv2000 Rv2001: Rv2001 - Conserved hypothetical protein, at 2,246,832 to 2,247,584 Rv2001 Rv2002: Rv2002 - Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase), at 2,247,660 to 2,248,442 Rv2002 Rv2003c: Rv2003c - Conserved hypothetical protein, at 2,248,563 to 2,249,420 Rv2003c
Group Condition Rv1999c Rv2000 Rv2001 Rv2002 Rv2003c
carbon source D-Trehalose 10 mM (C) +0.1 +0.1 -0.4 N.D. -5.7
stress 7H9 with Ethionamide 0.1 ug/mL +0.1 +0.1 -0.7 N.D. -3.1
nitrogen source Glycine 10 mM (N) -0.0 +0.1 +0.0 N.D. -3.7
nitrogen source L-Valine 10 mM (N) -0.0 -0.0 -2.9 N.D. -0.4
stress 7H9 with Bedaquiline 0.15 ug/mL -0.1 +0.1 -2.7 N.D. -0.3
carbon source casaminos 1 mg/mL (C) +0.0 -0.1 -0.1 N.D. -2.5
stress 7H9 with Erythromycin 0.016 mM -0.3 +0.2 -0.4 N.D. -2.1
stress 7H9 with Doxycycline hyclate 0.0035 mM -0.2 +0.0 -1.9 N.D. -0.3
stress 7H9 with Linezolid 0.44 ug/mL +0.1 +0.0 -0.5 N.D. -1.9
stress 7H9 with Irgasan 0.065 mM +0.0 +0.0 -0.6 N.D. -1.7
stress 7H9 with Chlorhexidine diacetate salt 0.0021 mM -0.1 +0.1 -1.8 N.D. -0.4
stress 7H9 with Hydrogen peroxide 2.5 mM; pH 5.5 +0.0 +0.2 -1.3 N.D. -1.0
stress 7H9 with Antimycin A 0.0186 mM +0.4 +0.0 -0.2 N.D. -2.3
no stress control no stress control +0.4 +0.1 -1.7 N.D. -0.9
carbon source L-Lactate 10 mM (C) -0.1 +0.2 -0.8 N.D. -1.3
stress 7H9 with Cumene hydroperoxide 0.05 mM +0.1 +0.2 -1.0 N.D. -1.1
stress 7H9 with Chlorhexidine diacetate salt 0.0021 mM -0.1 +0.1 -1.9 N.D. +0.3
stress 7H9 with Geneticin G418 0.35 mM +0.2 +0.1 -1.5 N.D. -0.5
stress 7H9 with Isoniazid 0.025 ug/mL +0.3 -0.1 -1.8 N.D. +0.2
stress 7H9 with 2,4-Dinitrophenol 0.1503 mM +0.0 -0.1 +0.5 N.D. -1.7
stress 7H9 with para-aminosalicylic 0.086 ug/mL +0.2 -0.0 +0.5 N.D. -1.6
stress 7H9 with Rifampicin 0.00045 ug/mL +0.0 +0.1 -1.7 N.D. +0.7
stress 7H9 with Clofazimine 0.072 ug/mL +0.1 +0.2 -1.5 N.D. +0.7
stress 7H9 with Linezolid 0.3 ug/mL +0.3 +0.2 +1.4 N.D. -1.2
stress 7H9 with Levofloxacin 0.3 ug/mL -0.1 +0.1 +1.0 N.D. +1.0
stress 7H9 with Malondialdehyde tetrabutylammonium salt 0.96 mM -0.2 +0.1 +1.1 N.D. +1.1
stress 7H9 with Hydrogen peroxide 3.97 mM +0.1 +0.0 +1.3 N.D. +0.8
carbon source oleate 200uM (C) +0.3 +0.2 +0.9 N.D. +0.9
no stress control no stress control +0.2 -0.1 +0.4 N.D. +1.8
nitrogen source Ammonium chloride 10mM (N) +0.0 +0.1 +0.9 N.D. +2.0
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