Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv1996 and Rv1997 are separated by 201 nucleotidesRv1997 and Rv1998c are separated by 68 nucleotidesRv1998c and Rv1999c are separated by 94 nucleotidesRv1999c and Rv2000 are separated by 70 nucleotides Rv1996: Rv1996 - Universal stress protein family protein, at 2,239,004 to 2,239,957 Rv1996 Rv1997: Rv1997 - Probable metal cation transporter P-type ATPase A CtpF, at 2,240,159 to 2,242,876 Rv1997 Rv1998c: Rv1998c - Conserved protein, at 2,242,945 to 2,243,721 Rv1998c Rv1999c: Rv1999c - Probable conserved integral membrane protein, at 2,243,816 to 2,245,138 Rv1999c Rv2000: Rv2000 - Unknown protein, at 2,245,209 to 2,246,822 Rv2000
Group Condition Rv1996 Rv1997 Rv1998c Rv1999c Rv2000
carbon source cholesterol 100uM (C) +0.1 -0.4 -0.5 -0.3 +0.0
stress 7H9 with Dicloxacillin 0.0069 mM -0.1 -0.4 -0.3 -0.1 +0.1
stress 7H9 with Hydrogen peroxide 2.5 mM; pH 6.5 -0.2 -0.2 -0.6 +0.1 +0.0
carbon source Glycerol (C) +0.1 -0.3 -0.5 +0.0 +0.0
stress 7H9 with 2-bromo-2-nitro-1,3-propanediol 0.1 mM -0.2 -0.1 -0.5 +0.1 +0.1
stress 7H9 with copper (II) chloride 0.08 mM -0.3 +0.2 +0.2 -0.5 +0.0
stress 7H9 with Cumene hydroperoxide 0.05 mM -0.3 -0.0 -0.3 +0.1 +0.2
stress 7H9 with Formaldehyde 0.23 mM +0.4 -0.1 -0.2 -0.1 -0.2
stress 7H9 with Pretomanid 0.213 ug/mL +0.0 -0.1 -0.5 +0.4 +0.1
carbon source oleate 200uM (C) -0.2 -0.1 -0.2 +0.3 +0.2
stress 7H9 with Norfloxacin 0.125 mM -0.1 -0.2 +0.5 -0.3 +0.1
no stress control no stress control -0.2 -0.3 +0.0 +0.2 +0.4
pH pH 4.5 -0.0 +0.3 -0.4 +0.1 +0.1
stress 7H9 with Ethionamide 0.1 ug/mL -0.1 -0.2 +0.2 +0.3 -0.0
stress 7H9 with nitrite 2.5 mM -0.4 -0.0 +0.5 -0.1 +0.1
carbon source D,L-Malic Acid 10 mM (C) -0.1 -0.3 +0.5 -0.1 +0.2
stress 7H9 with nitrate 4 mM +0.2 +0.1 +0.3 -0.4 +0.0
no stress control no stress control -0.0 +0.4 +0.2 -0.2 +0.1
carbon source D-Trehalose 10 mM (C) -0.1 -0.3 +0.6 +0.1 +0.1
stress 7H9 with Menadione 0.005 mM -0.2 +0.3 -0.2 +0.2 +0.3
carbon source L-Asparagine (C) +0.3 +0.3 -0.2 +0.1 -0.0
carbon source D-Trehalose 10 mM (C) -0.1 -0.1 +0.4 +0.2 +0.1
no stress control no stress control -0.0 -0.3 +0.4 +0.4 +0.1
nitrogen source L-Glutamine 10 mM (N) +0.0 +0.3 -0.3 +0.4 +0.2
no stress control no stress control -0.2 +0.2 +0.5 +0.1 +0.1
stress 7H9 with Hydrogen peroxide 2.5 mM; pH 5.5 -0.1 +0.2 +0.3 +0.3 +0.1
nitrogen source L-Asparagine 10 mM (N) -0.0 +0.5 -0.0 +0.4 +0.0
carbon source Palmitic 100 uM (C) +0.0 +0.1 +0.4 +0.2 +0.1
stress 7H9 with Dimethyl Sulfoxide 1 vol% -0.1 +0.2 +0.5 +0.4 -0.0
stress 7H9 with Thioridazine 0.028 mM -0.1 -0.1 +1.0 +0.1 +0.1
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