Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv1850 and Rv1851 overlap by 1 nucleotidesRv1851 and Rv1852 are separated by 10 nucleotidesRv1852 and Rv1853 are separated by 7 nucleotidesRv1853 and Rv1854c are separated by 2 nucleotides Rv1850: Rv1850 - Urease alpha subunit UreC (urea amidohydrolase), at 2,097,961 to 2,099,694 Rv1850 Rv1851: Rv1851 - Urease accessory protein UreF, at 2,099,694 to 2,100,329 Rv1851 Rv1852: Rv1852 - Urease accessory protein UreG, at 2,100,340 to 2,101,014 Rv1852 Rv1853: Rv1853 - Probable urease accessory protein UreD, at 2,101,022 to 2,101,648 Rv1853 Rv1854c: Rv1854c - Probable NADH dehydrogenase Ndh, at 2,101,651 to 2,103,042 Rv1854c
Group Condition Rv1850 Rv1851 Rv1852 Rv1853 Rv1854c
stress 7H9 with Rifampicin 0.00045 ug/mL -0.7 -2.0 +0.0 N.D. N.D.
stress 7H9 with Bedaquiline 0.15 ug/mL -0.0 -1.2 -0.2 N.D. N.D.
stress 7H9 with Bedaquiline 0.15 ug/mL +0.1 -1.4 +0.1 N.D. N.D.
carbon source Palmitic 100 uM (C) -0.0 -0.6 -0.5 N.D. N.D.
stress 7H9 with Ethambutol 0.75 ug/mL -0.6 -0.4 -0.1 N.D. N.D.
nitrogen source L-Glutamic 10 mM (N) -0.3 -0.4 -0.4 N.D. N.D.
carbon source butyrate 10 mM (C) +0.5 -1.3 -0.1 N.D. N.D.
stress 7H9 with Clofazimine 0.072 ug/mL -0.0 -1.0 +0.2 N.D. N.D.
carbon source heptadecanoic 250 uM (C) +0.2 -0.4 -0.5 N.D. N.D.
carbon source Palmitic 100 uM (C) +0.3 -0.8 -0.1 N.D. N.D.
carbon source Stearic 100 uM (C) +0.3 -0.5 -0.3 N.D. N.D.
stress 7H9 with Levofloxacin 0.3 ug/mL -0.6 -0.1 +0.5 N.D. N.D.
stress 7H9 with Moxifloxacin 0.121 ug/mL +0.9 -0.5 -0.5 N.D. N.D.
carbon source D-Lactate 10 mM (C) +0.4 -0.7 +0.1 N.D. N.D.
carbon source Stearic 100 uM (C) +0.4 -0.5 +0.2 N.D. N.D.
stress 7H9 with Pretomanid 0.213 ug/mL +0.6 -0.2 -0.3 N.D. N.D.
carbon source D-Glucose (C) +0.5 -0.4 +0.1 N.D. N.D.
carbon source D-Lactate 10 mM (C) +0.6 +0.1 -0.3 N.D. N.D.
nitrogen source L-Valine 10 mM (N) +0.8 -0.1 -0.1 N.D. N.D.
carbon source pyruvate (C) +0.5 +0.6 -0.3 N.D. N.D.
stress 7H9 with Isoniazid 0.025 ug/mL -0.9 +1.4 +0.4 N.D. N.D.
carbon source L-Asparagine (C) +0.4 +0.7 -0.1 N.D. N.D.
carbon source L-Lactate 10 mM (C) +0.4 -0.0 +0.6 N.D. N.D.
stress 7H9 with Moxifloxacin 0.121 ug/mL +0.2 +0.7 +0.2 N.D. N.D.
carbon source propionate (C) +0.2 +0.7 +0.4 N.D. N.D.
carbon source acetate (C) +1.0 +0.5 -0.1 N.D. N.D.
carbon source casaminos 1 mg/mL (C) +0.7 +0.4 +0.3 N.D. N.D.
stress 7H9 with Ethionamide 0.1 ug/mL +0.0 +1.1 +0.3 N.D. N.D.
carbon source propionate (C) +0.3 +1.0 +0.2 N.D. N.D.
carbon source acetate (C) +0.5 +1.2 -0.0 N.D. N.D.
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