Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv1845c and Rv1846c are separated by 14 nucleotidesRv1846c and Rv1847 are separated by 277 nucleotidesRv1847 and Rv1848 are separated by 48 nucleotidesRv1848 and Rv1849 overlap by 4 nucleotides Rv1845c: Rv1845c - Possible sensor-transducer protein BlaR, at 2,095,218 to 2,096,168 Rv1845c Rv1846c: Rv1846c - Transcriptional repressor BlaI, at 2,096,183 to 2,096,599 Rv1846c Rv1847: Rv1847 - Conserved protein, at 2,096,877 to 2,097,299 Rv1847 Rv1848: Rv1848 - Urease gamma subunit UreA (urea amidohydrolase), at 2,097,348 to 2,097,650 Rv1848 Rv1849: Rv1849 - Urease beta subunit UreB (urea amidohydrolase), at 2,097,647 to 2,097,961 Rv1849
Group Condition Rv1845c Rv1846c Rv1847 Rv1848 Rv1849
carbon source Stearic 100 uM (C) N.D. N.D. -0.5 N.D. N.D.
carbon source Stearic 100 uM (C) N.D. N.D. -0.5 N.D. N.D.
stress 7H9 with Linezolid 0.44 ug/mL N.D. N.D. -0.4 N.D. N.D.
stress 7H9 with Bedaquiline 0.15 ug/mL N.D. N.D. -0.4 N.D. N.D.
carbon source Palmitic 100 uM (C) N.D. N.D. -0.4 N.D. N.D.
stress 7H9 with Ofloxacin 0.8 ug/mL N.D. N.D. -0.3 N.D. N.D.
carbon source heptadecanoic 250 uM (C) N.D. N.D. -0.3 N.D. N.D.
carbon source D,L-Malic Acid 10 mM (C) N.D. N.D. -0.3 N.D. N.D.
stress 7H9 with Streptomycin 0.178 ug/mL N.D. N.D. -0.3 N.D. N.D.
carbon source L-Lactate 10 mM (C) N.D. N.D. -0.3 N.D. N.D.
stress 7H9 with Ofloxacin 0.8 ug/mL N.D. N.D. -0.2 N.D. N.D.
no stress control no stress control N.D. N.D. -0.2 N.D. N.D.
carbon source heptadecanoic 250 uM (C) N.D. N.D. -0.2 N.D. N.D.
carbon source D-Trehalose 10 mM (C) N.D. N.D. -0.2 N.D. N.D.
stress 7H9 with Levofloxacin 0.3 ug/mL N.D. N.D. -0.2 N.D. N.D.
stress 7H9 with Moxifloxacin 0.121 ug/mL N.D. N.D. -0.2 N.D. N.D.
carbon source pyruvate (C) N.D. N.D. -0.2 N.D. N.D.
carbon source D-Lactate 10 mM (C) N.D. N.D. -0.2 N.D. N.D.
carbon source D-Trehalose 10 mM (C) N.D. N.D. -0.2 N.D. N.D.
no stress control no stress control N.D. N.D. -0.2 N.D. N.D.
carbon source Palmitic 100 uM (C) N.D. N.D. -0.2 N.D. N.D.
carbon source casaminos 1 mg/mL (C) N.D. N.D. -0.2 N.D. N.D.
carbon source D,L-Malic Acid 10 mM (C) N.D. N.D. -0.2 N.D. N.D.
carbon source L-Aspartic Acid (C) N.D. N.D. +0.2 N.D. N.D.
nitrogen source L-Valine 10 mM (N) N.D. N.D. +0.2 N.D. N.D.
stress 7H9 with Rifampicin 0.014 ug/mL N.D. N.D. +0.3 N.D. N.D.
nitrogen source L-Glutamine 10 mM (N) N.D. N.D. +0.3 N.D. N.D.
stress 7H9 with Dimethyl Sulfoxide 1 vol% N.D. N.D. +0.4 N.D. N.D.
nitrogen source L-Alanine 10 mM (N) N.D. N.D. +0.4 N.D. N.D.
no stress control no stress control N.D. N.D. +0.4 N.D. N.D.
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