Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv1817 and Rv1818c are separated by 119 nucleotidesRv1818c and Rv1819c are separated by 134 nucleotidesRv1819c and Rv1820 are separated by 70 nucleotidesRv1820 and Rv1821 are separated by 14 nucleotides Rv1817: Rv1817 - Possible flavoprotein, at 2,059,595 to 2,061,058 Rv1817 Rv1818c: Rv1818c - PE-PGRS family protein PE_PGRS33, at 2,061,178 to 2,062,674 Rv1818c Rv1819c: Rv1819c - Probable drug-transport transmembrane ATP-binding protein ABC transporter BacA, at 2,062,809 to 2,064,728 Rv1819c Rv1820: Rv1820 - Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS), at 2,064,799 to 2,066,442 Rv1820 Rv1821: Rv1821 - Possible preprotein translocase ATPase SecA2, at 2,066,457 to 2,068,883 Rv1821
Group Condition Rv1817 Rv1818c Rv1819c Rv1820 Rv1821
stress 7H9 with Clofazimine 0.072 ug/mL +0.0 -0.1 -0.3 +0.1 -2.3
nitrogen source L-Aspartic Acid 10 mM (N) -0.1 -0.1 -0.2 +0.1 -1.9
stress 7H9 with Bedaquiline 0.15 ug/mL -0.0 +0.0 -0.2 +0.2 -2.2
stress 7H9 with Rifampicin 0.014 ug/mL -0.1 -0.5 -0.7 +0.3 -1.3
stress 7H9 with Meropenem 9.6 ug/mL -0.1 +0.1 -0.3 +0.1 -1.9
carbon source Glycerol (C) -0.0 -0.2 -0.0 +0.0 -1.8
stress 7H9 with Rifampicin 0.014 ug/mL -0.1 -0.1 -0.5 +0.2 -1.6
stress 7H9 with Clofazimine 0.072 ug/mL -0.0 -0.0 -0.2 +0.1 -1.7
nitrogen source Glycine 10 mM (N) -0.0 -0.2 -0.1 +0.1 -1.7
stress 7H9 with Bedaquiline 0.15 ug/mL -0.1 -0.1 -0.3 +0.1 -1.5
nitrogen source L-Asparagine 10 mM (N) -0.1 -0.1 +0.0 -0.0 -1.5
carbon source L-Aspartic Acid (C) +0.1 -0.3 -0.4 +0.1 -1.2
stress 7H9 with Delamanid 0.236 ug/mL +0.0 +0.1 -0.0 -0.1 -1.6
stress 7H9 with Meropenem 9.6 ug/mL +0.1 -0.1 -0.3 +0.2 -1.6
stress 7H9 with Rifampicin 0.00045 ug/mL +0.0 -0.2 -0.3 +0.2 -1.2
carbon source L-Aspartic Acid (C) -0.1 +0.1 -0.5 +0.2 -1.2
stress 7H9 with Isoniazid 0.025 ug/mL +0.1 -0.0 +0.2 -0.2 -1.5
carbon source acetate (C) +0.0 -0.0 -0.2 +0.4 -1.5
nitrogen source L-Serine 10 mM (N) -0.1 -0.2 -0.1 +0.2 -1.1
stress 7H9 with Rifampicin 0.00045 ug/mL +0.0 +0.2 -0.1 +0.1 -1.5
carbon source D-Glucose (C) +0.0 -0.0 +0.1 +0.4 -1.5
carbon source propionate (C) +0.1 -0.1 +0.2 +0.1 -1.3
no stress control no stress control +0.1 +0.1 +0.2 +0.2 -1.3
carbon source propionate (C) +0.1 +0.1 +0.2 +0.1 -1.3
carbon source Stearic 100 uM (C) -0.2 +0.2 +0.2 +0.5 -1.2
stress 7H9 with Moxifloxacin 0.121 ug/mL +0.3 +0.3 +0.2 +0.2 -0.8
stress 7H9 with Streptomycin 0.178 ug/mL +0.2 +0.4 +2.2 +0.6 -1.1
stress 7H9 with Streptomycin 0.178 ug/mL +0.3 +0.5 +2.0 +0.5 -0.9
stress 7H9 with Hygromycin B 0.0095 mM -0.1 +0.1 +3.2 +0.7 -0.3
stress 7H9 with Hygromycin B 0.0095 mM -0.1 +0.4 +3.3 +0.7 -0.5
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