Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv1661 and Rv1662 are separated by 19 nucleotidesRv1662 and Rv1663 overlap by 1 nucleotidesRv1663 and Rv1664 are separated by 5 nucleotidesRv1664 and Rv1665 are separated by 146 nucleotides Rv1661: Rv1661 - Probable polyketide synthase Pks7, at 1,875,304 to 1,881,684 Rv1661 Rv1662: Rv1662 - Probable polyketide synthase Pks8, at 1,881,704 to 1,886,512 Rv1662 Rv1663: Rv1663 - Probable polyketide synthase Pks17, at 1,886,512 to 1,888,020 Rv1663 Rv1664: Rv1664 - Probable polyketide synthase Pks9, at 1,888,026 to 1,891,079 Rv1664 Rv1665: Rv1665 - Chalcone synthase Pks11, at 1,891,226 to 1,892,287 Rv1665
Group Condition Rv1661 Rv1662 Rv1663 Rv1664 Rv1665
nitrogen source L-Glutamic 10 mM (N) -0.4 -0.4 -0.5 -0.1 -0.3
stress 7H9 with Ethionamide 0.1 ug/mL +0.1 -0.6 -0.2 -0.3 -0.8
no stress control no stress control +0.1 -0.0 -0.8 -0.2 -0.7
stress 7H9 with Phenazine ethosulfate 0.0137 mM +0.0 -0.4 -0.4 -0.2 -0.6
stress 7H9 with Norfloxacin 0.125 mM -0.1 -1.2 +0.2 -0.1 -0.0
stress 7H9 with Moxifloxacin 0.121 ug/mL -0.3 -0.6 +0.2 -0.3 -0.2
stress 7H9 with Dibucaine 0.21 mM +0.2 -0.5 -0.3 -0.0 -0.5
stress 7H9 with Novobiocin 0.004 mM -0.1 +0.2 -0.2 -0.5 -0.5
stress 7H9 with copper (II) chloride 0.08 mM -0.7 +0.1 +0.2 -0.3 -0.5
nitrogen source Glycine 10 mM (N) -0.1 +0.3 -0.5 -0.3 -0.3
stress 7H9 with Chlorhexidine diacetate salt 0.0021 mM +0.3 -0.1 -0.7 +0.1 -0.4
stress 7H9 with Dibucaine 0.21 mM -0.3 -0.9 +0.5 +0.2 -0.2
stress 7H9 with Meropenem 9.6 ug/mL -0.2 +0.5 -0.4 -0.1 -0.4
stress 7H9 with Pyrazinamide 50 ug/mL; pH 5.5 +0.3 -0.4 -0.1 +0.4 -0.5
nitrogen source Glycine 10 mM (N) +0.2 +0.5 -0.6 -0.2 -0.2
nitrogen source Urea 10mM (N) +0.5 -0.3 -0.3 -0.4 +0.2
stress 7H9 with Thioridazine 0.028 mM -0.0 +0.7 -0.5 +0.1 -0.4
stress 7H9 with Cloxacillin 0.0386 mM +0.1 -0.4 -0.4 -0.2 +0.7
no stress control no stress control -0.4 +0.5 -0.3 -0.2 +0.3
stress 7H9 with nitrite 3 mM; pH 5.5 +0.2 +0.7 -0.7 -0.1 -0.2
stress 7H9 with Dodecyl Sulfate 0.02 vol% +0.1 +0.8 -0.2 -0.2 -0.5
stress 7H9 with Dimethyl Sulfoxide 1 vol% -0.3 +0.8 -0.2 -0.2 -0.1
stress 7H9 with Lomefloxacin 0.0035 mM -0.2 +0.8 -0.6 -0.2 +0.4
no stress control no stress control -0.1 +0.8 -0.4 -0.2 +0.1
stress 7H9 with Sisomicin 0.07 mM -0.2 -0.6 +0.4 -0.1 +0.6
no stress control no stress control -0.0 -0.0 +0.6 -0.7 +0.3
pH pH 5.5 +0.0 +1.1 -0.2 -0.0 -0.5
no stress control no stress control +0.1 +1.0 -0.4 +0.2 -0.3
stress 7H9 with Levofloxacin 0.3 ug/mL -0.3 -0.3 +0.6 +0.1 +0.7
stress 7H9 with Moxifloxacin 0.121 ug/mL -0.2 +0.6 +0.1 +0.0 +0.6
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