Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv1659 and Rv1660 are separated by 108 nucleotidesRv1660 and Rv1661 are separated by 82 nucleotidesRv1661 and Rv1662 are separated by 19 nucleotidesRv1662 and Rv1663 overlap by 1 nucleotides Rv1659: Rv1659 - Probable argininosuccinate lyase ArgH, at 1,872,639 to 1,874,051 Rv1659 Rv1660: Rv1660 - Chalcone synthase Pks10, at 1,874,160 to 1,875,221 Rv1660 Rv1661: Rv1661 - Probable polyketide synthase Pks7, at 1,875,304 to 1,881,684 Rv1661 Rv1662: Rv1662 - Probable polyketide synthase Pks8, at 1,881,704 to 1,886,512 Rv1662 Rv1663: Rv1663 - Probable polyketide synthase Pks17, at 1,886,512 to 1,888,020 Rv1663
Group Condition Rv1659 Rv1660 Rv1661 Rv1662 Rv1663
nitrogen source L-Glutamic 10 mM (N) N.D. -0.2 -0.4 -0.4 -0.5
stress 7H9 with Norfloxacin 0.125 mM N.D. -0.2 -0.4 -0.8 -0.0
stress 7H9 with Norfloxacin 0.125 mM N.D. -0.2 -0.1 -1.2 +0.2
stress 7H9 with Clofazimine 0.072 ug/mL N.D. -0.0 -0.1 -0.5 -0.6
stress 7H9 with Streptomycin 0.178 ug/mL N.D. -0.3 +0.1 -0.6 -0.3
stress 7H9 with Ethionamide 0.1 ug/mL N.D. -0.3 +0.1 -0.6 -0.2
stress 7H9 with Chloramphenicol 0.01 mM N.D. +0.2 -0.2 -0.5 -0.4
stress 7H9 with nitrite 5 mM N.D. +0.0 -0.3 -0.7 +0.2
nitrogen source L-Glutamic 10 mM (N) N.D. -0.5 +0.2 +0.2 -0.4
stress 7H9 with Dibucaine 0.21 mM N.D. +0.1 -0.3 -0.9 +0.5
stress 7H9 with Sisomicin 0.07 mM N.D. -0.1 -0.2 -0.6 +0.4
stress 7H9 with Doxycycline hyclate 0.0035 mM N.D. +0.3 +0.3 -0.8 -0.2
no stress control no stress control N.D. -0.1 -0.4 +0.5 -0.3
stress 7H9 with Ofloxacin 0.8 ug/mL N.D. -0.3 -0.3 -0.0 +0.5
stress 7H9 with Levofloxacin 0.3 ug/mL N.D. -0.1 -0.3 -0.3 +0.6
nitrogen source Glycine 10 mM (N) N.D. -0.2 +0.2 +0.5 -0.6
stress 7H9 with Lomefloxacin 0.0035 mM N.D. -0.1 -0.2 +0.8 -0.6
stress 7H9 with Chlorhexidine diacetate salt 0.0021 mM N.D. +0.3 +0.3 -0.1 -0.7
stress 7H9 with Hygromycin B 0.0095 mM N.D. +0.0 -0.4 +0.6 -0.4
stress 7H9 with nitrite 3 mM; pH 5.5 N.D. -0.4 +0.2 +0.7 -0.7
no stress control no stress control N.D. -0.1 -0.1 +0.8 -0.4
stress 7H9 with Phenazine methosulfate 0.0054 mM N.D. +0.3 +0.4 -0.3 -0.2
stress 7H9 with Nickel (II) chloride 0.6 mM N.D. +0.3 +0.2 -0.5 +0.3
stress 7H9 with Dimethyl Sulfoxide 1 vol% N.D. -0.0 -0.3 +0.8 -0.2
stress 7H9 with Thioridazine 0.028 mM N.D. +0.1 -0.0 +0.7 -0.5
nitrogen source Urea 10mM (N) N.D. +0.4 +0.5 -0.3 -0.3
no stress control no stress control N.D. -0.1 +0.1 +1.0 -0.4
stress 7H9 with Doxycycline hyclate 0.0035 mM N.D. +0.2 +0.2 +0.6 -0.2
stress 7H9 with Dodecyl Sulfate 0.02 vol% N.D. +0.2 +0.1 +0.8 -0.2
pH pH 5.5 N.D. -0.1 +0.0 +1.1 -0.2
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