Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv1638A and Rv1639c are separated by 15 nucleotidesRv1639c and Rv1640c are separated by 58 nucleotidesRv1640c and Rv1641 are separated by 237 nucleotidesRv1641 and Rv1642 are separated by 49 nucleotides Rv1638A: Rv1638A - Conserved hypothetical protein, at 1,846,716 to 1,846,973 Rv1638A Rv1639c: Rv1639c - Conserved hypothetical membrane protein, at 1,846,989 to 1,848,458 Rv1639c Rv1640c: Rv1640c - Lysyl-tRNA synthetase 2 LysX, at 1,848,517 to 1,852,035 Rv1640c Rv1641: Rv1641 - Probable initiation factor if-3 InfC, at 1,852,273 to 1,852,878 Rv1641 Rv1642: Rv1642 - 50S ribosomal protein L35 RpmI, at 1,852,928 to 1,853,122 Rv1642
Group Condition Rv1638A Rv1639c Rv1640c Rv1641 Rv1642
stress 7H9 with Hygromycin B 0.0095 mM N.D. -0.2 -1.8 N.D. N.D.
stress 7H9 with Hygromycin B 0.0095 mM N.D. -0.3 -1.6 N.D. N.D.
stress 7H9 with Streptomycin 0.178 ug/mL N.D. -0.1 -1.8 N.D. N.D.
nitrogen source L-Serine 10 mM (N) N.D. -0.2 -1.7 N.D. N.D.
stress 7H9 with Streptomycin 0.178 ug/mL N.D. -0.1 -1.8 N.D. N.D.
nitrogen source L-Serine 10 mM (N) N.D. +0.1 -1.5 N.D. N.D.
stress 7H9 with Rifampicin 0.014 ug/mL N.D. -0.1 -1.3 N.D. N.D.
stress 7H9 with Bedaquiline 0.15 ug/mL N.D. -0.3 -1.1 N.D. N.D.
stress 7H9 with Ethambutol 0.75 ug/mL N.D. -0.2 -1.1 N.D. N.D.
stress 7H9 with Ethionamide 0.1 ug/mL N.D. -0.3 -0.9 N.D. N.D.
nitrogen source L-Alanine 10 mM (N) N.D. -0.0 -1.2 N.D. N.D.
stress 7H9 with Clofazimine 0.072 ug/mL N.D. +0.1 -1.3 N.D. N.D.
stress 7H9 with Clofazimine 0.072 ug/mL N.D. -0.1 -1.1 N.D. N.D.
stress 7H9 with Rifampicin 0.014 ug/mL N.D. -0.1 -1.0 N.D. N.D.
no stress control no stress control N.D. -0.9 -0.2 N.D. N.D.
carbon source heptadecanoic 250 uM (C) N.D. -0.3 -0.7 N.D. N.D.
stress 7H9 with Rifampicin 0.00045 ug/mL N.D. -0.1 -0.9 N.D. N.D.
carbon source propionate (C) N.D. +0.0 -0.9 N.D. N.D.
carbon source Stearic 100 uM (C) N.D. -0.3 -0.6 N.D. N.D.
carbon source heptadecanoic 250 uM (C) N.D. -0.0 -0.8 N.D. N.D.
stress 7H9 with Rifampicin 0.00045 ug/mL N.D. -0.0 -0.8 N.D. N.D.
stress 7H9 with Isoniazid 0.025 ug/mL N.D. -0.3 -0.5 N.D. N.D.
carbon source Glycerol (C) N.D. -0.1 -0.6 N.D. N.D.
nitrogen source L-Alanine 10 mM (N) N.D. +0.2 -0.9 N.D. N.D.
nitrogen source Glycine 10 mM (N) N.D. +0.1 -0.7 N.D. N.D.
stress 7H9 with Ethambutol 0.75 ug/mL N.D. +0.2 -0.7 N.D. N.D.
stress 7H9 with Ofloxacin 0.8 ug/mL N.D. -0.6 +0.2 N.D. N.D.
stress 7H9 with Delamanid 0.236 ug/mL N.D. +0.2 -0.6 N.D. N.D.
stress 7H9 with Clarithromycin 0.967 ug/mL N.D. +0.3 -0.5 N.D. N.D.
no stress control no stress control N.D. +0.6 -0.3 N.D. N.D.
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