Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv1621c and Rv1622c are separated by 86 nucleotidesRv1622c and Rv1623c are separated by 29 nucleotidesRv1623c and Rv1624c are separated by 110 nucleotidesRv1624c and Rv1625c are separated by 28 nucleotides Rv1621c: Rv1621c - Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydD, at 1,821,690 to 1,823,273 Rv1621c Rv1622c: Rv1622c - Probable integral membrane cytochrome D ubiquinol oxidase (subunit II) CydB (cytochrome BD-I oxidase subunit II), at 1,823,360 to 1,824,400 Rv1622c Rv1623c: Rv1623c - Probable integral membrane cytochrome D ubiquinol oxidase (subunit I) CydA (cytochrome BD-I oxidase subunit I), at 1,824,430 to 1,825,887 Rv1623c Rv1624c: Rv1624c - Probable conserved membrane protein, at 1,825,998 to 1,826,585 Rv1624c Rv1625c: Rv1625c - Membrane-anchored adenylyl cyclase Cya (ATP pyrophosphate-lyase) (adenylate cyclase), at 1,826,614 to 1,827,945 Rv1625c
Group Condition Rv1621c Rv1622c Rv1623c Rv1624c Rv1625c
stress 7H9 with Clofazimine 0.072 ug/mL -3.9 N.D. N.D. -0.9 -0.0
stress 7H9 with Clofazimine 0.072 ug/mL -3.7 N.D. N.D. -0.7 -0.1
stress 7H9 with Clofazimine 0.45 ug/mL -1.7 N.D. N.D. -1.6 -0.2
stress 7H9 with Bedaquiline 0.15 ug/mL -3.7 N.D. N.D. +0.2 +0.2
stress 7H9 with Bedaquiline 0.15 ug/mL -3.1 N.D. N.D. +0.2 +0.1
no stress control no stress control -2.5 N.D. N.D. -0.4 +0.1
stress 7H9 with Clofazimine 0.45 ug/mL -1.7 N.D. N.D. -0.8 -0.2
no stress control no stress control -2.4 N.D. N.D. -0.3 -0.0
no stress control no stress control -2.3 N.D. N.D. -0.3 -0.1
stress 7H9 with Dimethyl Sulfoxide 1 vol% -1.6 N.D. N.D. -0.6 +0.0
stress 7H9 with Rifampicin 0.00045 ug/mL -2.1 N.D. N.D. -0.3 +0.2
stress 7H9 with Rifampicin 0.014 ug/mL -2.0 N.D. N.D. -0.4 +0.2
stress 7H9 with Ethionamide 0.1 ug/mL -1.2 N.D. N.D. -0.9 +0.0
stress 7H9 with Dimethyl Sulfoxide 1 vol% -1.3 N.D. N.D. -0.5 -0.1
stress 7H9 with Rifampicin 0.014 ug/mL -2.4 N.D. N.D. +0.2 +0.3
stress 7H9 with Hygromycin B 0.0095 mM -1.3 N.D. N.D. -0.5 -0.0
no stress control no stress control -1.5 N.D. N.D. -0.2 -0.1
carbon source Stearic 100 uM (C) -2.1 N.D. N.D. +0.3 -0.1
stress 7H9 with Meropenem 9.6 ug/mL -1.8 N.D. N.D. -0.0 +0.1
carbon source Stearic 100 uM (C) -1.4 N.D. N.D. -0.3 -0.1
stress 7H9 with Streptomycin 0.178 ug/mL -1.0 N.D. N.D. -0.6 -0.1
nitrogen source L-Serine 10 mM (N) -1.4 N.D. N.D. -0.2 -0.0
stress 7H9 with Rifampicin 0.00045 ug/mL -2.0 N.D. N.D. +0.0 +0.3
no stress control no stress control -1.8 N.D. N.D. +0.2 -0.0
no stress control no stress control -1.9 N.D. N.D. +0.2 +0.2
stress 7H9 with Delamanid 0.236 ug/mL -1.3 N.D. N.D. -0.2 +0.2
nitrogen source L-Aspartic Acid 10 mM (N) -1.3 N.D. N.D. +0.2 +0.1
stress 7H9 with Linezolid 0.44 ug/mL -1.4 N.D. N.D. +0.4 +0.2
stress 7H9 with Ethambutol 0.75 ug/mL -1.4 N.D. N.D. +0.4 +0.4
stress 7H9 with Meropenem 9.6 ug/mL -1.2 N.D. N.D. +0.4 +0.2
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