Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv1598c and Rv1599 are separated by 99 nucleotidesRv1599 and Rv1600 overlap by 4 nucleotidesRv1600 and Rv1601 overlap by 4 nucleotidesRv1601 and Rv1602 overlap by 4 nucleotides Rv1598c: Rv1598c - Conserved protein, at 1,799,073 to 1,799,483 Rv1598c Rv1599: Rv1599 - Probable histidinol dehydrogenase HisD (HDH), at 1,799,583 to 1,800,899 Rv1599 Rv1600: Rv1600 - Probable histidinol-phosphate aminotransferase HisC1, at 1,800,896 to 1,802,038 Rv1600 Rv1601: Rv1601 - Probable imidazole glycerol-phosphate dehydratase HisB, at 1,802,035 to 1,802,667 Rv1601 Rv1602: Rv1602 - Probable amidotransferase HisH, at 1,802,664 to 1,803,284 Rv1602
Group Condition Rv1598c Rv1599 Rv1600 Rv1601 Rv1602
stress 7H9 with Levofloxacin 0.3 ug/mL -0.7 N.D. N.D. N.D. N.D.
carbon source L-Lactate 10 mM (C) -0.6 N.D. N.D. N.D. N.D.
stress 7H9 with Delamanid 0.236 ug/mL -0.6 N.D. N.D. N.D. N.D.
stress 7H9 with Dimethyl Sulfoxide 1 vol% -0.6 N.D. N.D. N.D. N.D.
no stress control no stress control -0.5 N.D. N.D. N.D. N.D.
stress 7H9 with Clarithromycin 0.967 ug/mL -0.5 N.D. N.D. N.D. N.D.
carbon source butyrate 10 mM (C) -0.5 N.D. N.D. N.D. N.D.
carbon source butyrate 10 mM (C) -0.5 N.D. N.D. N.D. N.D.
carbon source L-Asparagine (C) -0.4 N.D. N.D. N.D. N.D.
carbon source D,L-Malic Acid 10 mM (C) -0.4 N.D. N.D. N.D. N.D.
carbon source L-Glutamine (C) -0.4 N.D. N.D. N.D. N.D.
carbon source D-Glucose (C) -0.4 N.D. N.D. N.D. N.D.
nitrogen source L-Valine 10 mM (N) -0.4 N.D. N.D. N.D. N.D.
stress 7H9 with Ofloxacin 0.8 ug/mL -0.4 N.D. N.D. N.D. N.D.
carbon source Valeric 10 mM (C) -0.3 N.D. N.D. N.D. N.D.
carbon source L-Lactate 10 mM (C) -0.3 N.D. N.D. N.D. N.D.
stress 7H9 with Delamanid 0.236 ug/mL -0.3 N.D. N.D. N.D. N.D.
carbon source D-Lactate 10 mM (C) -0.3 N.D. N.D. N.D. N.D.
stress 7H9 with Bedaquiline 0.15 ug/mL +0.3 N.D. N.D. N.D. N.D.
stress 7H9 with Sulfamethizole 0.026 mM +0.3 N.D. N.D. N.D. N.D.
no stress control no stress control +0.4 N.D. N.D. N.D. N.D.
stress 7H9 with para-aminosalicylic 0.086 ug/mL +0.4 N.D. N.D. N.D. N.D.
nitrogen source L-Alanine 10 mM (N) +0.4 N.D. N.D. N.D. N.D.
nitrogen source L-Serine 10 mM (N) +0.4 N.D. N.D. N.D. N.D.
stress 7H9 with Ethambutol 0.75 ug/mL +0.4 N.D. N.D. N.D. N.D.
stress 7H9 with Streptomycin 0.178 ug/mL +0.4 N.D. N.D. N.D. N.D.
no stress control no stress control +0.4 N.D. N.D. N.D. N.D.
stress 7H9 with Ethambutol 0.75 ug/mL +0.5 N.D. N.D. N.D. N.D.
stress 7H9 with Streptomycin 0.178 ug/mL +0.5 N.D. N.D. N.D. N.D.
stress 7H9 with Clofazimine 0.072 ug/mL +0.5 N.D. N.D. N.D. N.D.
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