Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv1527c and Rv1528c are separated by 543 nucleotidesRv1528c and Rv1529 are separated by 51 nucleotidesRv1529 and Rv1530 are separated by 116 nucleotidesRv1530 and Rv1531 overlap by 4 nucleotides Rv1527c: Rv1527c - Probable polyketide synthase Pks5, at 1,722,083 to 1,728,409 Rv1527c Rv1528c: Rv1528c - Probable conserved polyketide synthase associated protein PapA4, at 1,728,953 to 1,729,450 Rv1528c Rv1529: Rv1529 - Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase), at 1,729,502 to 1,731,256 Rv1529 Rv1530: Rv1530 - Probable alcohol dehydrogenase Adh, at 1,731,373 to 1,732,476 Rv1530 Rv1531: Rv1531 - Conserved protein, at 1,732,473 to 1,733,039 Rv1531
Group Condition Rv1527c Rv1528c Rv1529 Rv1530 Rv1531
stress 7H9 with Isoniazid 0.025 ug/mL -0.1 -0.2 -0.2 +0.2 -2.2
stress 7H9 with nitrite 2.5 mM +0.1 -0.1 -0.1 -0.6 -1.5
stress 7H9 with nitrite 1.5 mM; pH 5.5 +0.0 -0.8 -0.2 -0.2 -0.8
stress 7H9 with Dodecyl Sulfate 0.02 vol% -0.0 -0.3 +0.4 +0.1 -2.2
carbon source propionate (C) +0.1 -0.2 -0.0 -0.1 -1.5
no stress control no stress control +0.0 +0.1 -0.1 -0.5 -1.2
stress 7H9 with Geneticin G418 0.35 mM -0.0 +0.4 +0.2 -0.3 -1.9
stress 7H9 with Amikacin di2 ug/mL +0.2 -0.1 -0.0 -0.4 -1.3
stress 7H9 with Linezolid 0.44 ug/mL -0.1 +0.5 -0.1 +0.1 -2.1
nitrogen source L-Valine 10 mM (N) +0.0 +0.4 -0.2 -0.1 -1.7
stress 7H9 with Levofloxacin 0.3 ug/mL -0.1 +0.3 -0.1 -0.3 -1.4
carbon source cholesterol 100uM (C) +0.1 -0.7 +0.2 -0.1 -0.9
stress 7H9 with Clofazimine 0.45 ug/mL +0.0 +0.1 +0.1 -0.0 -1.5
stress 7H9 with para-aminosalicylic 0.086 ug/mL -0.0 +0.1 +0.1 +0.0 -1.6
no stress control no stress control +0.1 +0.2 +0.0 -0.1 -1.5
stress 7H9 with Rifampicin 0.00045 ug/mL +0.0 +0.2 -0.2 -0.2 -1.2
stress 7H9 with Levofloxacin 0.3 ug/mL +0.0 -0.4 +0.0 +0.3 -1.0
stress 7H9 with copper (II) chloride 0.08 mM +0.1 -0.1 +0.2 +0.3 -1.3
stress 7H9 with Linezolid 0.3 ug/mL -0.1 +0.1 +0.1 +0.4 -1.1
stress 7H9 with Sisomicin 0.07 mM +0.1 -0.7 +0.3 +0.0 +0.7
stress 7H9 with Ethionamide 0.1 ug/mL -0.2 -0.3 -0.1 +0.2 +0.9
no stress control no stress control -0.1 +0.1 -0.4 +0.5 +0.7
stress 7H9 with Hydrogen peroxide 2.5 mM; pH 5.5 -0.1 +0.5 -0.2 -0.4 +1.1
stress 7H9 with Sulfaquinoxaline 0.097 mM -0.1 +0.4 -0.1 -0.3 +1.0
nitrogen source L-Glutamic 10 mM (N) -0.1 +0.0 +0.2 -0.3 +1.3
stress 7H9 with Ciprofloxacin Hydrochloride 0.0012 mM +0.2 +0.2 -0.1 -0.1 +1.1
stress 7H9 with Moxifloxacin 0.121 ug/mL -0.0 +0.1 -0.3 +0.5 +1.1
stress 7H9 with Ethambutol 0.75 ug/mL +0.1 -0.1 -0.3 -0.2 +1.9
no stress control no stress control +0.0 -0.1 -0.2 -0.1 +2.0
stress 7H9 with Spectinomycin 0.029 mM +0.1 +0.6 -0.0 +0.1 +1.0
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