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Protein
Homologs
Fitness for 5 genes in
Mycobacterium tuberculosis H37Rv
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Top 30 experiments (either direction), sorted by average fitness
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500 nt
Rv1527c and Rv1528c are separated by 543 nucleotides
Rv1528c and Rv1529 are separated by 51 nucleotides
Rv1529 and Rv1530 are separated by 116 nucleotides
Rv1530 and Rv1531 overlap by 4 nucleotides
Rv1527c: Rv1527c - Probable polyketide synthase Pks5, at 1,722,083 to 1,728,409
Rv1527c
Rv1528c: Rv1528c - Probable conserved polyketide synthase associated protein PapA4, at 1,728,953 to 1,729,450
Rv1528c
Rv1529: Rv1529 - Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase), at 1,729,502 to 1,731,256
Rv1529
Rv1530: Rv1530 - Probable alcohol dehydrogenase Adh, at 1,731,373 to 1,732,476
Rv1530
Rv1531: Rv1531 - Conserved protein, at 1,732,473 to 1,733,039
Rv1531
Group
Condition
Rv1527c
Rv1528c
Rv1529
Rv1530
Rv1531
stress
7H9 with Isoniazid 0.025 ug/mL
-0.1
-0.2
-0.2
+0.2
-2.2
stress
7H9 with nitrite 2.5 mM
+0.1
-0.1
-0.1
-0.6
-1.5
stress
7H9 with nitrite 1.5 mM; pH 5.5
+0.0
-0.8
-0.2
-0.2
-0.8
stress
7H9 with Dodecyl Sulfate 0.02 vol%
-0.0
-0.3
+0.4
+0.1
-2.2
carbon source
propionate (C)
+0.1
-0.2
-0.0
-0.1
-1.5
no stress control
no stress control
+0.0
+0.1
-0.1
-0.5
-1.2
stress
7H9 with Geneticin G418 0.35 mM
-0.0
+0.4
+0.2
-0.3
-1.9
stress
7H9 with Amikacin di2 ug/mL
+0.2
-0.1
-0.0
-0.4
-1.3
stress
7H9 with Linezolid 0.44 ug/mL
-0.1
+0.5
-0.1
+0.1
-2.1
nitrogen source
L-Valine 10 mM (N)
+0.0
+0.4
-0.2
-0.1
-1.7
stress
7H9 with Levofloxacin 0.3 ug/mL
-0.1
+0.3
-0.1
-0.3
-1.4
carbon source
cholesterol 100uM (C)
+0.1
-0.7
+0.2
-0.1
-0.9
stress
7H9 with Clofazimine 0.45 ug/mL
+0.0
+0.1
+0.1
-0.0
-1.5
stress
7H9 with para-aminosalicylic 0.086 ug/mL
-0.0
+0.1
+0.1
+0.0
-1.6
no stress control
no stress control
+0.1
+0.2
+0.0
-0.1
-1.5
stress
7H9 with Rifampicin 0.00045 ug/mL
+0.0
+0.2
-0.2
-0.2
-1.2
stress
7H9 with Levofloxacin 0.3 ug/mL
+0.0
-0.4
+0.0
+0.3
-1.0
stress
7H9 with copper (II) chloride 0.08 mM
+0.1
-0.1
+0.2
+0.3
-1.3
stress
7H9 with Linezolid 0.3 ug/mL
-0.1
+0.1
+0.1
+0.4
-1.1
stress
7H9 with Sisomicin 0.07 mM
+0.1
-0.7
+0.3
+0.0
+0.7
stress
7H9 with Ethionamide 0.1 ug/mL
-0.2
-0.3
-0.1
+0.2
+0.9
no stress control
no stress control
-0.1
+0.1
-0.4
+0.5
+0.7
stress
7H9 with Hydrogen peroxide 2.5 mM; pH 5.5
-0.1
+0.5
-0.2
-0.4
+1.1
stress
7H9 with Sulfaquinoxaline 0.097 mM
-0.1
+0.4
-0.1
-0.3
+1.0
nitrogen source
L-Glutamic 10 mM (N)
-0.1
+0.0
+0.2
-0.3
+1.3
stress
7H9 with Ciprofloxacin Hydrochloride 0.0012 mM
+0.2
+0.2
-0.1
-0.1
+1.1
stress
7H9 with Moxifloxacin 0.121 ug/mL
-0.0
+0.1
-0.3
+0.5
+1.1
stress
7H9 with Ethambutol 0.75 ug/mL
+0.1
-0.1
-0.3
-0.2
+1.9
no stress control
no stress control
+0.0
-0.1
-0.2
-0.1
+2.0
stress
7H9 with Spectinomycin 0.029 mM
+0.1
+0.6
-0.0
+0.1
+1.0
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