Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv1523 and Rv1524 are separated by 29 nucleotidesRv1524 and Rv1525 are separated by 46 nucleotidesRv1525 and Rv1526c overlap by 23 nucleotidesRv1526c and Rv1527c are separated by 22 nucleotides Rv1523: Rv1523 - Probable methyltransferase, at 1,717,653 to 1,718,696 Rv1523 Rv1524: Rv1524 - Probable glycosyltransferase, at 1,718,726 to 1,719,970 Rv1524 Rv1525: Rv1525 - Possible rhamnosyl transferase WbbL2, at 1,720,017 to 1,720,802 Rv1525 Rv1526c: Rv1526c - Probable glycosyltransferase, at 1,720,780 to 1,722,060 Rv1526c Rv1527c: Rv1527c - Probable polyketide synthase Pks5, at 1,722,083 to 1,728,409 Rv1527c
Group Condition Rv1523 Rv1524 Rv1525 Rv1526c Rv1527c
stress 7H9 with Ciprofloxacin Hydrochloride 0.001 mM -0.1 -0.6 N.D. -0.0 -0.2
stress 7H9 with Ofloxacin 0.8 ug/mL -0.1 -0.6 N.D. +0.1 -0.2
stress 7H9 with copper (II) chloride 0.08 mM -0.0 -0.8 N.D. +0.2 +0.1
pH pH 4.5 +0.1 -0.6 N.D. -0.1 +0.0
stress 7H9 with Pyrazinamide 50 ug/mL; pH 5.5 +0.3 -0.6 N.D. -0.1 +0.0
stress 7H9 with Ethionamide 0.1 ug/mL +0.0 -0.3 N.D. +0.3 -0.2
stress 7H9 with Levofloxacin 0.3 ug/mL -0.1 -0.4 N.D. +0.4 -0.1
stress 7H9 with hypochlorite 0.4 vol% -0.3 +0.5 N.D. -0.2 -0.0
stress 7H9 with Dibucaine 0.21 mM +0.3 +0.2 N.D. -0.3 -0.2
stress 7H9 with Econazole nitrate salt 0.0082 mM -0.2 +0.6 N.D. -0.1 -0.1
stress 7H9 with Dicloxacillin 0.0069 mM -0.2 +0.6 N.D. -0.0 -0.2
stress 7H9 with Linezolid 0.44 ug/mL +0.2 +0.4 N.D. -0.2 -0.1
stress 7H9 with nitrite 1.5 mM; pH 5.5 +0.3 +0.3 N.D. -0.3 +0.0
no stress control no stress control +0.3 -0.3 N.D. +0.1 +0.2
nitrogen source L-Valine 10 mM (N) -0.2 +0.6 N.D. -0.0 +0.0
stress 7H9 with Lomefloxacin 0.0035 mM -0.2 +0.6 N.D. -0.1 +0.0
stress 7H9 with Rifampicin 0.00045 ug/mL +0.1 +0.5 N.D. -0.3 +0.0
stress 7H9 with 2,4-Dinitrophenol 0.1503 mM -0.2 +0.6 N.D. +0.1 +0.1
no stress control no stress control -0.1 +0.8 N.D. -0.0 -0.0
stress 7H9 with Amikacin di2 ug/mL +0.1 +0.5 N.D. -0.1 +0.2
stress 7H9 with Meropenem 9.6 ug/mL +0.3 -0.2 N.D. +0.5 +0.1
nitrogen source Ammonium chloride 10mM (N) +0.1 +0.8 N.D. +0.0 -0.1
stress 7H9 with Ciprofloxacin Hydrochloride 0.001 mM -0.0 +0.7 N.D. -0.0 +0.2
stress 7H9 with Doxycycline hyclate 0.0035 mM +0.2 +0.6 N.D. -0.1 +0.1
stress 7H9 with Antimycin A 0.0186 mM +0.1 +0.8 N.D. -0.1 +0.1
stress 7H9 with Econazole nitrate salt 0.0082 mM -0.0 +1.0 N.D. +0.0 +0.0
carbon source pyruvate (C) +0.2 +0.6 N.D. +0.1 +0.1
stress 7H9 with Phenazine ethosulfate 0.0137 mM +0.2 +0.6 N.D. +0.2 +0.0
stress 7H9 with Hydrogen peroxide 2.5 mM; pH 6.5 +0.1 +0.9 N.D. +0.1 -0.1
stress 7H9 with Dibucaine 0.21 mM +0.3 +0.8 N.D. +0.1 -0.1
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