Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv1487 and Rv1488 are separated by 21 nucleotidesRv1488 and Rv1489 are separated by 9 nucleotidesRv1489 and Rv1489A are separated by 33 nucleotidesRv1489A and Rv1490 are separated by 149 nucleotides Rv1487: Rv1487 - Conserved membrane protein, at 1,676,941 to 1,677,375 Rv1487 Rv1488: Rv1488 - Possible exported conserved protein, at 1,677,397 to 1,678,542 Rv1488 Rv1489: Rv1489 - Conserved protein, at 1,678,552 to 1,678,908 Rv1489 Rv1489A: Rv1489A - Conserved protein, at 1,678,942 to 1,679,172 Rv1489A Rv1490: Rv1490 - Probable membrane protein, at 1,679,322 to 1,680,629 Rv1490
Group Condition Rv1487 Rv1488 Rv1489 Rv1489A Rv1490
pH pH 4.5 -0.8 -0.1 -0.0 N.D. -0.6
stress 7H9 with Norfloxacin 0.125 mM -0.6 -0.3 -0.2 N.D. -0.3
stress 7H9 with Hydrogen peroxide 2.5 mM; pH 5.5 -0.9 -0.1 -0.0 N.D. -0.4
stress 7H9 with Linezolid 0.44 ug/mL -0.5 -0.2 -0.1 N.D. -0.5
nitrogen source L-Glutamic 10 mM (N) -0.1 -0.1 -0.3 N.D. -0.8
stress 7H9 with Clofazimine 0.45 ug/mL -0.2 -0.2 -0.2 N.D. -0.6
stress 7H9 with Hydrogen peroxide 2.5 mM; pH 6.5 -0.3 +0.1 -0.4 N.D. -0.6
stress 7H9 with nitrite 1.5 mM; pH 5.5 -1.1 +0.1 -0.1 N.D. +0.2
nitrogen source Ammonium chloride 10mM (N) +0.2 +0.3 -0.3 N.D. -1.1
pH 7H9 pH 5.5 -0.4 +0.1 +0.1 N.D. -0.7
no stress control no stress control -0.9 -0.1 -0.1 N.D. +0.4
stress 7H9 with Thioridazine 0.028 mM +0.3 -0.1 -0.5 N.D. -0.3
stress 7H9 with 2,4-Dinitrophenol 0.1503 mM +0.5 -0.0 -0.4 N.D. -0.5
stress 7H9 with copper (II) chloride 0.08 mM -0.4 -0.0 -0.4 N.D. +0.4
carbon source L-Aspartic Acid (C) +0.3 +0.2 -0.3 N.D. -0.5
no stress control no stress control +0.3 +0.2 -0.4 N.D. -0.4
stress 7H9 with Isoniazid 0.025 ug/mL +0.1 -0.2 -0.7 N.D. +0.8
stress 7H9 with Ethionamide 0.1 ug/mL +0.5 -0.2 -0.7 N.D. +0.3
stress 7H9 with Amikacin di2 ug/mL +0.6 -0.1 -0.4 N.D. +0.1
no stress control no stress control -0.7 +0.1 +0.1 N.D. +0.8
nitrogen source Urea 10mM (N) +0.5 +0.2 -0.1 N.D. -0.4
stress 7H9 with 2-Mercaptopyridine N-oxide 0.0078 mM +0.6 +0.2 +0.1 N.D. -0.5
stress 7H9 with Moxifloxacin 0.121 ug/mL +0.3 +0.1 -0.3 N.D. +0.4
stress 7H9 with nitrite 5 mM +0.3 -0.1 -0.2 N.D. +0.6
nitrogen source Ammonium chloride 10mM (N) +0.7 +0.3 -0.1 N.D. -0.3
stress 7H9 with Ofloxacin 0.8 ug/mL +0.2 -0.0 -0.3 N.D. +0.7
carbon source heptadecanoic 250 uM (C) +0.6 +0.0 -0.4 N.D. +0.6
stress 7H9 with Formaldehyde 0.23 mM +0.9 +0.0 -0.1 N.D. +0.4
stress 7H9 with Ramoplanin 0.009 mM +0.3 +0.1 -0.0 N.D. +0.8
stress 7H9 with 8-hydroxy-nitroquinoline 0.03 mM +0.8 -0.0 +0.0 N.D. +0.5
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