Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv1485 and Rv1486c overlap by 35 nucleotidesRv1486c and Rv1487 are separated by 57 nucleotidesRv1487 and Rv1488 are separated by 21 nucleotidesRv1488 and Rv1489 are separated by 9 nucleotides Rv1485: Rv1485 - Ferrochelatase HemZ (protoheme ferro-lyase) (heme synthetase), at 1,675,017 to 1,676,051 Rv1485 Rv1486c: Rv1486c - Conserved hypothetical protein, at 1,676,017 to 1,676,883 Rv1486c Rv1487: Rv1487 - Conserved membrane protein, at 1,676,941 to 1,677,375 Rv1487 Rv1488: Rv1488 - Possible exported conserved protein, at 1,677,397 to 1,678,542 Rv1488 Rv1489: Rv1489 - Conserved protein, at 1,678,552 to 1,678,908 Rv1489
Group Condition Rv1485 Rv1486c Rv1487 Rv1488 Rv1489
stress 7H9 with Hydrogen peroxide 2.5 mM; pH 5.5 N.D. -0.1 -0.9 -0.1 -0.0
stress 7H9 with nitrite 1.5 mM; pH 5.5 N.D. -0.0 -1.1 +0.1 -0.1
stress 7H9 with Isoniazid 0.025 ug/mL N.D. -0.3 +0.1 -0.2 -0.7
no stress control no stress control N.D. +0.0 -0.9 -0.1 -0.1
stress 7H9 with Norfloxacin 0.125 mM N.D. +0.3 -0.6 -0.3 -0.2
stress 7H9 with Malondialdehyde tetrabutylammonium salt 0.96 mM N.D. -0.5 -0.4 -0.2 +0.1
pH pH 4.5 N.D. +0.3 -0.8 -0.1 -0.0
stress 7H9 with Linezolid 0.44 ug/mL N.D. +0.3 -0.5 -0.2 -0.1
stress 7H9 with Ethionamide 0.1 ug/mL N.D. -0.2 +0.5 -0.2 -0.7
stress 7H9 with Malondialdehyde tetrabutylammonium salt 0.96 mM N.D. -1.0 +0.4 +0.0 +0.1
stress 7H9 with Ethionamide 0.1 ug/mL N.D. -0.3 +0.3 +0.1 -0.4
no stress control no stress control N.D. +0.2 -0.7 +0.1 +0.1
stress 7H9 with copper (II) chloride 0.08 mM N.D. +0.5 -0.4 -0.0 -0.4
stress 7H9 with Thioridazine 0.028 mM N.D. +0.3 +0.3 -0.1 -0.5
stress 7H9 with Rifampicin 0.014 ug/mL N.D. +0.5 -0.4 +0.1 -0.2
stress 7H9 with Hydrogen peroxide 2.5 mM; pH 5.5 N.D. -0.3 -0.3 +0.3 +0.3
stress 7H9 with Amikacin di2 ug/mL N.D. -0.0 +0.6 -0.1 -0.4
stress 7H9 with copper (II) chloride 0.08 mM N.D. +0.6 -0.5 -0.0 -0.0
no stress control no stress control N.D. -0.1 +0.3 +0.2 -0.4
nitrogen source Ammonium chloride 10mM (N) N.D. +0.2 +0.2 +0.3 -0.3
stress 7H9 with Formaldehyde 0.23 mM N.D. -0.4 +0.9 +0.0 -0.1
stress 7H9 with Tetrazolium violet 0.065 mM N.D. +0.3 -0.3 +0.3 +0.2
carbon source heptadecanoic 250 uM (C) N.D. +0.3 +0.6 +0.0 -0.4
stress 7H9 with Moxifloxacin 0.121 ug/mL N.D. +0.4 +0.3 +0.1 -0.3
stress 7H9 with methylglyoxal 1.2 mM N.D. -0.2 +0.1 +0.2 +0.6
stress 7H9 with Meropenem 9.6 ug/mL N.D. +0.5 -0.1 +0.3 +0.1
nitrogen source Ammonium chloride 10mM (N) N.D. +0.1 +0.7 +0.3 -0.1
stress 7H9 with Pretomanid 0.213 ug/mL N.D. +0.5 +0.3 +0.2 -0.0
stress 7H9 with 2-Mercaptopyridine N-oxide 0.0078 mM N.D. +0.2 +0.6 +0.2 +0.1
no stress control no stress control N.D. +0.3 +0.5 +0.3 -0.1
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