Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv1475c and Rv1476 are separated by 157 nucleotidesRv1476 and Rv1477 are separated by 225 nucleotidesRv1477 and Rv1478 are separated by 10 nucleotidesRv1478 and Rv1479 are separated by 138 nucleotides Rv1475c: Rv1475c - Probable iron-regulated aconitate hydratase Acn (citrate hydro-lyase) (aconitase), at 1,663,215 to 1,666,046 Rv1475c Rv1476: Rv1476 - Possible membrane protein, at 1,666,204 to 1,666,764 Rv1476 Rv1477: Rv1477 - Peptidoglycan hydrolase, at 1,666,990 to 1,668,408 Rv1477 Rv1478: Rv1478 - Possible invasion protein, at 1,668,419 to 1,669,144 Rv1478 Rv1479: Rv1479 - Probable transcriptional regulatory protein MoxR1, at 1,669,283 to 1,670,416 Rv1479
Group Condition Rv1475c Rv1476 Rv1477 Rv1478 Rv1479
stress 7H9 with Meropenem 9.6 ug/mL N.D. N.D. N.D. -0.6 N.D.
pH pH 4.5 N.D. N.D. N.D. -0.5 N.D.
stress 7H9 with Meropenem 9.6 ug/mL N.D. N.D. N.D. -0.5 N.D.
stress 7H9 with Moxifloxacin 0.121 ug/mL N.D. N.D. N.D. -0.4 N.D.
stress 7H9 with Rifampicin 0.014 ug/mL N.D. N.D. N.D. -0.4 N.D.
stress 7H9 with Ceftriaxone hemi(heptahydrate) 0.12 mM N.D. N.D. N.D. -0.4 N.D.
stress 7H9 with Ceftriaxone hemi(heptahydrate) 0.12 mM N.D. N.D. N.D. -0.4 N.D.
pH pH 4.5 N.D. N.D. N.D. -0.4 N.D.
stress 7H9 with methylglyoxal 1.2 mM N.D. N.D. N.D. -0.4 N.D.
stress 7H9 with Moxifloxacin 0.121 ug/mL N.D. N.D. N.D. -0.4 N.D.
stress 7H9 with Ofloxacin 0.8 ug/mL N.D. N.D. N.D. -0.4 N.D.
stress 7H9 with Linezolid 0.44 ug/mL N.D. N.D. N.D. -0.4 N.D.
carbon source cholesterol 100uM (C) N.D. N.D. N.D. -0.4 N.D.
no stress control no stress control N.D. N.D. N.D. -0.4 N.D.
carbon source L-Lactate 10 mM (C) N.D. N.D. N.D. -0.4 N.D.
no stress control no stress control N.D. N.D. N.D. -0.4 N.D.
stress 7H9 with Hydrogen peroxide 2.5 mM; pH 5.5 N.D. N.D. N.D. -0.4 N.D.
stress 7H9 with methylglyoxal 1.2 mM N.D. N.D. N.D. -0.3 N.D.
stress 7H9 with 2-Mercaptopyridine N-oxide 0.0078 mM N.D. N.D. N.D. -0.3 N.D.
stress 7H9 with Rifampicin 0.014 ug/mL N.D. N.D. N.D. -0.3 N.D.
stress 7H9 with nitrite 3 mM; pH 5.5 N.D. N.D. N.D. -0.3 N.D.
stress 7H9 with EDTA (disodium salt) 0.2 mM N.D. N.D. N.D. -0.3 N.D.
stress 7H9 with Chlorpromazine 0.054 mM N.D. N.D. N.D. -0.3 N.D.
stress 7H9 with copper (II) chloride 0.08 mM N.D. N.D. N.D. -0.3 N.D.
stress 7H9 with Linezolid 0.44 ug/mL N.D. N.D. N.D. -0.3 N.D.
stress 7H9 with Hydrogen peroxide 3.97 mM N.D. N.D. N.D. -0.3 N.D.
stress 7H9 with 8-hydroxy-nitroquinoline 0.03 mM N.D. N.D. N.D. +0.3 N.D.
nitrogen source L-Alanine 10 mM (N) N.D. N.D. N.D. +0.3 N.D.
stress 7H9 with Isoniazid 0.025 ug/mL N.D. N.D. N.D. +0.4 N.D.
stress 7H9 with nitrite 5 mM N.D. N.D. N.D. +0.5 N.D.
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