Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv1448c and Rv1449c are separated by 16 nucleotidesRv1449c and Rv1450c are separated by 438 nucleotidesRv1450c and Rv1451 are separated by 401 nucleotidesRv1451 and Rv1452c are separated by 48 nucleotides Rv1448c: Rv1448c - Probable transaldolase Tal, at 1,626,959 to 1,628,080 Rv1448c Rv1449c: Rv1449c - Transketolase Tkt (TK), at 1,628,097 to 1,630,199 Rv1449c Rv1450c: Rv1450c - PE-PGRS family protein PE_PGRS27, at 1,630,638 to 1,634,627 Rv1450c Rv1451: Rv1451 - Probable cytochrome C oxidase assembly factor CtaB, at 1,635,029 to 1,635,955 Rv1451 Rv1452c: Rv1452c - PE-PGRS family protein PE_PGRS28, at 1,636,004 to 1,638,229 Rv1452c
Group Condition Rv1448c Rv1449c Rv1450c Rv1451 Rv1452c
stress 7H9 with Moxifloxacin 0.121 ug/mL -0.9 N.D. -1.5 N.D. -0.3
pH pH 4.5 -0.6 N.D. -1.8 N.D. -0.1
stress 7H9 with Moxifloxacin 0.121 ug/mL -0.1 N.D. -1.8 N.D. +0.0
stress 7H9 with nitrate 4 mM -0.8 N.D. -0.3 N.D. -0.7
stress 7H9 with Isoniazid 0.025 ug/mL +0.0 N.D. -1.4 N.D. -0.1
stress 7H9 with Ciprofloxacin Hydrochloride 0.001 mM -0.3 N.D. -1.0 N.D. -0.2
stress 7H9 with Pyrazinamide 50 ug/mL; pH 5.5 -0.3 N.D. -1.2 N.D. +0.1
stress 7H9 with Ethionamide 0.1 ug/mL +0.3 N.D. -1.8 N.D. +0.1
nitrogen source L-Serine 10 mM (N) -0.6 N.D. -1.0 N.D. +0.2
pH pH 4.5 +0.3 N.D. -1.2 N.D. -0.2
stress 7H9 with 2,4-Dinitrophenol 0.1503 mM -1.2 N.D. +0.4 N.D. -0.1
stress 7H9 with Amikacin di2 ug/mL -0.4 N.D. +0.3 N.D. -0.7
stress 7H9 with Hydrogen peroxide 2.5 mM; pH 6.5 -0.7 N.D. +0.6 N.D. -0.4
no stress control no stress control -0.0 N.D. -1.1 N.D. +0.7
stress 7H9 with Sisomicin 0.07 mM -0.9 N.D. +0.5 N.D. -0.0
no stress control no stress control +0.2 N.D. -0.9 N.D. +0.3
stress 7H9 with Dimethyl Sulfoxide 1 vol% +0.5 N.D. -1.0 N.D. +0.2
stress 7H9 with copper (II) chloride 0.08 mM -0.8 N.D. +0.3 N.D. +0.4
no stress control no stress control +0.6 N.D. -0.8 N.D. +0.1
stress 7H9 with Linezolid 0.44 ug/mL +0.7 N.D. +0.4 N.D. -0.5
carbon source cholesterol 100uM (C) -0.5 N.D. +0.7 N.D. +0.3
stress 7H9 with Chlorhexidine diacetate salt 0.0021 mM -0.4 N.D. +1.0 N.D. +0.0
stress 7H9 with 2-bromo-2-nitro-1,3-propanediol 0.1 mM +0.2 N.D. +1.0 N.D. -0.4
no stress control no stress control -0.4 N.D. +1.1 N.D. +0.2
carbon source D-Lactate 10 mM (C) -0.4 N.D. +1.2 N.D. +0.1
carbon source cholesterol 100uM (C) -0.3 N.D. +1.5 N.D. +0.1
stress 7H9 with Ceftriaxone hemi(heptahydrate) 0.12 mM -0.3 N.D. +1.2 N.D. +0.4
stress 7H9 with Chloramphenicol 0.01 mM +0.6 N.D. +0.8 N.D. +0.3
stress 7H9 with Chlorpromazine 0.054 mM +0.5 N.D. +1.2 N.D. +0.1
stress 7H9 with Thioridazine 0.028 mM +0.7 N.D. +1.3 N.D. +0.1
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