Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv1418 and Rv1419 are separated by 179 nucleotidesRv1419 and Rv1420 are separated by 63 nucleotidesRv1420 and Rv1421 overlap by 4 nucleotidesRv1421 and Rv1422 overlap by 4 nucleotides Rv1418: Rv1418 - Probable lipoprotein LprH, at 1,592,639 to 1,593,325 Rv1418 Rv1419: Rv1419 - Unknown protein, at 1,593,505 to 1,593,978 Rv1419 Rv1420: Rv1420 - Probable excinuclease ABC (subunit C-nuclease) UvrC, at 1,594,042 to 1,595,982 Rv1420 Rv1421: Rv1421 - Conserved protein, at 1,595,979 to 1,596,884 Rv1421 Rv1422: Rv1422 - Conserved hypothetical protein, at 1,596,881 to 1,597,909 Rv1422
Group Condition Rv1418 Rv1419 Rv1420 Rv1421 Rv1422
stress 7H9 with Malondialdehyde tetrabutylammonium salt 0.96 mM -0.2 N.D. -1.4 -3.7 -0.7
stress 7H9 with Erythromycin 0.016 mM -0.0 N.D. -1.2 -1.5 -2.8
stress 7H9 with Cumene hydroperoxide 0.05 mM -0.0 N.D. -2.5 -0.8 -1.9
no stress control no stress control -0.2 N.D. -0.4 -1.4 -3.0
stress 7H9 with Clofazimine 0.072 ug/mL +0.0 N.D. -0.4 -2.3 -1.9
stress 7H9 with Nickel (II) chloride 0.6 mM +0.2 N.D. -0.3 -3.6 -0.9
stress 7H9 with 2-Mercaptopyridine N-oxide 0.0078 mM -0.2 N.D. -2.2 -2.1 -0.1
stress 7H9 with Malondialdehyde tetrabutylammonium salt 0.96 mM -0.3 N.D. -1.2 -3.8 +0.8
stress 7H9 with Sulfamethizole 0.026 mM +0.1 N.D. -2.1 -2.0 -0.5
stress 7H9 with Econazole nitrate salt 0.0082 mM -0.2 N.D. -1.5 -2.5 -0.0
stress 7H9 with Tetrazolium violet 0.065 mM -0.0 N.D. -1.3 -3.4 +0.5
stress 7H9 with Clofazimine 0.45 ug/mL -0.1 N.D. -0.1 -2.9 -1.1
no stress control no stress control -0.1 N.D. -0.9 -1.3 -1.8
stress 7H9 with Geneticin G418 0.35 mM +0.1 N.D. -0.9 -2.9 -0.3
stress 7H9 with Linezolid 0.3 ug/mL -0.2 N.D. -1.0 -0.6 -1.9
stress 7H9 with Econazole nitrate salt 0.0082 mM -0.2 N.D. -1.2 -2.2 -0.3
stress 7H9 with para-aminosalicylic 0.086 ug/mL -0.1 N.D. -0.9 -3.1 +0.5
stress 7H9 with Clarithromycin 0.967 ug/mL -0.2 N.D. -0.9 -3.0 +0.5
stress 7H9 with nitrate 4 mM +0.2 N.D. -1.0 -2.2 -0.6
stress 7H9 with para-aminosalicylic 0.086 ug/mL +0.1 N.D. -1.4 -2.3 +0.2
nitrogen source Glycine 10 mM (N) +0.4 N.D. -0.8 -2.2 -0.7
stress 7H9 with Sulfamethizole 0.026 mM +0.2 N.D. -2.1 -2.4 +1.1
stress 7H9 with Phenazine ethosulfate 0.0137 mM -0.1 N.D. -1.4 -2.3 +0.6
stress 7H9 with Phenazine ethosulfate 0.0137 mM +0.1 N.D. -1.6 -2.5 +0.8
stress 7H9 with Clarithromycin 0.967 ug/mL -0.1 N.D. -0.9 -3.1 +1.1
pH 7H9 pH 5.5 -0.3 N.D. -0.2 +0.5 -2.8
stress 7H9 with Sulfaquinoxaline 0.097 mM +0.2 N.D. -0.8 -2.9 +0.9
stress 7H9 with Rifampicin 0.014 ug/mL +0.2 N.D. +0.7 -2.8 -0.4
nitrogen source Glycine 10 mM (N) +0.2 N.D. -0.9 -1.6 +1.2
carbon source cholesterol 100uM (C) +0.2 N.D. +0.4 +1.6 +2.4
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