Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv1414 and Rv1415 are separated by 104 nucleotidesRv1415 and Rv1416 overlap by 4 nucleotidesRv1416 and Rv1417 overlap by 4 nucleotidesRv1417 and Rv1418 are separated by 24 nucleotides Rv1414: Rv1414 - Conserved hypothetical protein, at 1,589,891 to 1,590,292 Rv1414 Rv1415: Rv1415 - Probable riboflavin biosynthesis protein RibA2 : GTP cyclohydrolase II + 3,4-dihydroxy-2-butanone 4-phosphate synthase (DHBP synthase), at 1,590,397 to 1,591,674 Rv1415 Rv1416: Rv1416 - Probable riboflavin synthase beta chain RibH (6,7-dimethyl-8-ribityllumazine synthase) (DMRL synthase) (lumazine synthase), at 1,591,671 to 1,592,153 Rv1416 Rv1417: Rv1417 - Possible conserved membrane protein, at 1,592,150 to 1,592,614 Rv1417 Rv1418: Rv1418 - Probable lipoprotein LprH, at 1,592,639 to 1,593,325 Rv1418
Group Condition Rv1414 Rv1415 Rv1416 Rv1417 Rv1418
stress 7H9 with copper (II) chloride 0.08 mM -2.5 N.D. N.D. N.D. -0.1
no stress control no stress control -1.6 N.D. N.D. N.D. -0.4
stress 7H9 with Dodecyl Sulfate 0.02 vol% -1.8 N.D. N.D. N.D. -0.2
stress 7H9 with nitrate 4 mM -2.0 N.D. N.D. N.D. +0.2
stress 7H9 with Streptomycin 0.178 ug/mL -1.7 N.D. N.D. N.D. -0.1
stress 7H9 with copper (II) chloride 0.08 mM -1.7 N.D. N.D. N.D. +0.0
stress 7H9 with Menadione 0.005 mM -1.5 N.D. N.D. N.D. -0.2
stress 7H9 with Linezolid 0.44 ug/mL -1.2 N.D. N.D. N.D. -0.4
stress 7H9 with Chlorpromazine 0.054 mM -1.8 N.D. N.D. N.D. +0.2
stress 7H9 with Ciprofloxacin Hydrochloride 0.0012 mM -1.8 N.D. N.D. N.D. +0.3
stress 7H9 with 8-hydroxy-nitroquinoline 0.03 mM -1.2 N.D. N.D. N.D. -0.2
stress 7H9 with Sisomicin 0.07 mM -1.9 N.D. N.D. N.D. +0.5
stress 7H9 with Delamanid 0.236 ug/mL -1.4 N.D. N.D. N.D. -0.0
stress 7H9 with methylglyoxal 1.2 mM -1.6 N.D. N.D. N.D. +0.2
stress 7H9 with Malondialdehyde tetrabutylammonium salt 0.96 mM -1.2 N.D. N.D. N.D. -0.2
stress 7H9 with Irgasan 0.065 mM -1.3 N.D. N.D. N.D. -0.1
carbon source acetate (C) -1.3 N.D. N.D. N.D. +0.2
stress 7H9 with methylglyoxal 1.2 mM -1.2 N.D. N.D. N.D. +0.2
stress 7H9 with Rifampicin 0.00045 ug/mL +1.3 N.D. N.D. N.D. -0.1
stress 7H9 with Streptomycin 0.178 ug/mL +1.3 N.D. N.D. N.D. -0.1
stress 7H9 with Bedaquiline 0.15 ug/mL +1.5 N.D. N.D. N.D. -0.2
stress 7H9 with Bedaquiline 0.15 ug/mL +1.4 N.D. N.D. N.D. +0.0
stress 7H9 with Dimethyl Sulfoxide 1 vol% +1.4 N.D. N.D. N.D. +0.0
stress 7H9 with Linezolid 0.44 ug/mL +1.6 N.D. N.D. N.D. -0.1
pH pH 5.5 +1.3 N.D. N.D. N.D. +0.3
stress 7H9 with nitrite 1.5 mM; pH 5.5 +1.3 N.D. N.D. N.D. +0.2
stress 7H9 with Rifampicin 0.014 ug/mL +1.6 N.D. N.D. N.D. +0.2
stress 7H9 with Hydrogen peroxide 2.5 mM; pH 5.5 +1.8 N.D. N.D. N.D. +0.1
stress 7H9 with Isoniazid 0.025 ug/mL +1.6 N.D. N.D. N.D. +0.5
no stress control no stress control +2.4 N.D. N.D. N.D. +0.0
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