Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv1404 and Rv1405c are separated by 71 nucleotidesRv1405c and Rv1406 are separated by 196 nucleotidesRv1406 and Rv1407 overlap by 4 nucleotidesRv1407 and Rv1408 are separated by 24 nucleotides Rv1404: Rv1404 - Probable transcriptional regulatory protein, at 1,580,591 to 1,581,073 Rv1404 Rv1405c: Rv1405c - Putative methyltransferase, at 1,581,145 to 1,581,969 Rv1405c Rv1406: Rv1406 - Probable methionyl-tRNA formyltransferase Fmt, at 1,582,166 to 1,583,104 Rv1406 Rv1407: Rv1407 - Probable Fmu protein (sun protein), at 1,583,101 to 1,584,474 Rv1407 Rv1408: Rv1408 - Probable ribulose-phosphate 3-epimerase Rpe (PPE) (R5P3E) (pentose-5-phosphate 3-epimerase), at 1,584,499 to 1,585,197 Rv1408
Group Condition Rv1404 Rv1405c Rv1406 Rv1407 Rv1408
stress 7H9 with Geneticin G418 0.35 mM N.D. -0.2 N.D. -0.3 N.D.
pH 7H9 pH 5.5 N.D. -0.2 N.D. -0.4 N.D.
stress 7H9 with Tetracycline 0.0058 mM N.D. -0.0 N.D. -0.5 N.D.
stress 7H9 with Sisomicin 0.07 mM N.D. -0.0 N.D. -0.5 N.D.
stress 7H9 with Sulfamethizole 0.026 mM N.D. +0.1 N.D. -0.6 N.D.
stress 7H9 with Dodecyl Sulfate 0.02 vol% N.D. -0.1 N.D. -0.4 N.D.
stress 7H9 with Dimethyl Sulfoxide 1 vol% N.D. -0.1 N.D. -0.4 N.D.
stress 7H9 with Pyrazinamide 50 ug/mL; pH 5.5 N.D. -0.0 N.D. -0.5 N.D.
carbon source D-Glucose (C) N.D. -0.1 N.D. -0.4 N.D.
stress 7H9 with nitrite 3 mM; pH 5.5 N.D. -0.4 N.D. -0.1 N.D.
stress 7H9 with 8-hydroxy-nitroquinoline 0.03 mM N.D. -0.0 N.D. -0.4 N.D.
stress 7H9 with nitrate 4 mM N.D. -0.4 N.D. +0.0 N.D.
stress 7H9 with Sulfamethizole 0.026 mM N.D. +0.1 N.D. -0.5 N.D.
stress 7H9 with Dimethyl Sulfoxide 1 vol% N.D. +0.2 N.D. -0.5 N.D.
stress 7H9 with Chlorhexidine diacetate salt 0.0021 mM N.D. +0.1 N.D. -0.4 N.D.
stress 7H9 with nitrite 5 mM N.D. -0.4 N.D. +0.1 N.D.
stress 7H9 with Menadione 0.005 mM N.D. +0.1 N.D. -0.4 N.D.
stress 7H9 with Amikacin di2 ug/mL N.D. +0.2 N.D. -0.4 N.D.
stress 7H9 with 2-Mercaptopyridine N-oxide 0.0078 mM N.D. +0.2 N.D. -0.4 N.D.
stress 7H9 with Antimycin A 0.0186 mM N.D. +0.3 N.D. -0.4 N.D.
stress 7H9 with Phenazine ethosulfate 0.0137 mM N.D. +0.2 N.D. -0.3 N.D.
pH 7H9 pH 5.5 N.D. +0.2 N.D. -0.3 N.D.
stress 7H9 with Tetrazolium violet 0.065 mM N.D. +0.2 N.D. -0.3 N.D.
pH pH 4.5 N.D. -0.3 N.D. +0.3 N.D.
carbon source cholesterol 100uM (C) N.D. +0.3 N.D. -0.3 N.D.
carbon source D-Trehalose 10 mM (C) N.D. -0.3 N.D. +0.3 N.D.
pH pH 4.5 N.D. -0.4 N.D. +0.5 N.D.
stress 7H9 with Sisomicin 0.07 mM N.D. +0.4 N.D. -0.2 N.D.
stress 7H9 with Isoniazid 0.025 ug/mL N.D. +0.0 N.D. +0.5 N.D.
no stress control no stress control N.D. +0.2 N.D. +0.3 N.D.
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