Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv1384 and Rv1385 overlap by 4 nucleotidesRv1385 and Rv1386 are separated by 194 nucleotidesRv1386 and Rv1387 overlap by 4 nucleotidesRv1387 and Rv1388 are separated by 305 nucleotides Rv1384: Rv1384 - Probable carbamoyl-phosphate synthase large chain CarB (carbamoyl-phosphate synthetase ammonia chain), at 1,557,101 to 1,560,448 Rv1384 Rv1385: Rv1385 - Probable orotidine 5'-phosphate decarboxylase PyrF (OMP decarboxylase) (ompdecase), at 1,560,445 to 1,561,269 Rv1385 Rv1386: Rv1386 - PE family protein PE15, at 1,561,464 to 1,561,772 Rv1386 Rv1387: Rv1387 - PPE family protein PPE20, at 1,561,769 to 1,563,388 Rv1387 Rv1388: Rv1388 - Putative integration host factor MihF, at 1,563,694 to 1,564,266 Rv1388
Group Condition Rv1384 Rv1385 Rv1386 Rv1387 Rv1388
carbon source heptadecanoic 250 uM (C) N.D. N.D. -0.6 -0.4 N.D.
stress 7H9 with Hydrogen peroxide 3.97 mM N.D. N.D. -0.6 -0.3 N.D.
stress 7H9 with Meropenem 9.6 ug/mL N.D. N.D. -0.3 -0.4 N.D.
stress 7H9 with Meropenem 9.6 ug/mL N.D. N.D. -0.1 -0.5 N.D.
stress 7H9 with Isoniazid 0.025 ug/mL N.D. N.D. -0.3 -0.4 N.D.
stress 7H9 with Nickel (II) chloride 0.6 mM N.D. N.D. -0.7 +0.1 N.D.
stress 7H9 with Hydrogen peroxide 2.5 mM; pH 5.5 N.D. N.D. -0.6 +0.1 N.D.
stress 7H9 with Sisomicin 0.07 mM N.D. N.D. -0.5 +0.2 N.D.
pH pH 5.5 N.D. N.D. +0.5 -0.2 N.D.
no stress control no stress control N.D. N.D. +0.6 -0.2 N.D.
stress 7H9 with Ciprofloxacin Hydrochloride 0.001 mM N.D. N.D. +0.6 -0.1 N.D.
nitrogen source L-Glutamine 10 mM (N) N.D. N.D. +0.6 -0.1 N.D.
stress 7H9 with 2-Mercaptopyridine N-oxide 0.0078 mM N.D. N.D. +0.6 +0.0 N.D.
nitrogen source Urea 10mM (N) N.D. N.D. +0.3 +0.3 N.D.
no stress control no stress control N.D. N.D. +0.7 -0.0 N.D.
stress 7H9 with Levofloxacin 0.3 ug/mL N.D. N.D. +0.6 +0.1 N.D.
nitrogen source L-Alanine 10 mM (N) N.D. N.D. +0.4 +0.3 N.D.
nitrogen source Urea 10mM (N) N.D. N.D. +0.6 +0.1 N.D.
nitrogen source L-Alanine 10 mM (N) N.D. N.D. +0.5 +0.2 N.D.
stress 7H9 with nitrite 1.5 mM; pH 5.5 N.D. N.D. +0.8 +0.0 N.D.
no stress control no stress control N.D. N.D. +0.7 +0.1 N.D.
nitrogen source Glycine 10 mM (N) N.D. N.D. +0.7 +0.1 N.D.
nitrogen source L-Aspartic Acid 10 mM (N) N.D. N.D. +0.8 +0.1 N.D.
nitrogen source Glycine 10 mM (N) N.D. N.D. +0.6 +0.3 N.D.
no stress control no stress control N.D. N.D. +0.8 +0.1 N.D.
nitrogen source L-Asparagine 10 mM (N) N.D. N.D. +0.9 +0.1 N.D.
stress 7H9 with Rifampicin 0.014 ug/mL N.D. N.D. +0.8 +0.2 N.D.
stress 7H9 with Novobiocin 0.004 mM N.D. N.D. +0.8 +0.6 N.D.
stress 7H9 with copper (II) chloride 0.08 mM N.D. N.D. +1.6 +1.9 N.D.
stress 7H9 with copper (II) chloride 0.08 mM N.D. N.D. +2.5 +2.6 N.D.
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