Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv1327c and Rv1328 are separated by 138 nucleotidesRv1328 and Rv1329c are separated by 39 nucleotidesRv1329c and Rv1330c are separated by 23 nucleotidesRv1330c and Rv1331 are separated by 101 nucleotides Rv1327c: Rv1327c - Probable glucanase GlgE, at 1,492,320 to 1,494,425 Rv1327c Rv1328: Rv1328 - Probable glycogen phosphorylase GlgP, at 1,494,564 to 1,497,155 Rv1328 Rv1329c: Rv1329c - Probable ATP-dependent helicase DinG, at 1,497,195 to 1,499,189 Rv1329c Rv1330c: Rv1330c - Nicotinic acid phosphoribosyltransferase PncB1, at 1,499,213 to 1,500,559 Rv1330c Rv1331: Rv1331 - Conserved hypothetical protein, at 1,500,661 to 1,500,966 Rv1331
Group Condition Rv1327c Rv1328 Rv1329c Rv1330c Rv1331
carbon source D-Trehalose 10 mM (C) N.D. -1.2 -0.2 +0.1 -0.7
nitrogen source L-Serine 10 mM (N) N.D. -0.2 -0.2 -0.1 -1.1
carbon source D-Trehalose 10 mM (C) N.D. -1.2 +0.2 -0.0 -0.4
carbon source L-Lactate 10 mM (C) N.D. +0.1 -0.4 +0.0 -1.2
stress 7H9 with Meropenem 9.6 ug/mL N.D. -0.3 -0.2 -0.2 -0.7
nitrogen source L-Serine 10 mM (N) N.D. -0.1 -0.2 -0.0 -1.0
nitrogen source L-Valine 10 mM (N) N.D. -0.1 -0.3 -0.3 -0.6
nitrogen source L-Alanine 10 mM (N) N.D. +0.3 -0.2 -0.1 -1.2
carbon source Glycerol (C) N.D. -0.4 -0.3 -0.2 -0.3
carbon source Valeric 10 mM (C) N.D. +0.1 -0.1 -0.1 -0.9
stress 7H9 with Bedaquiline 0.15 ug/mL N.D. -0.1 +0.0 +0.1 -1.1
nitrogen source L-Alanine 10 mM (N) N.D. +0.3 +0.1 -0.0 -1.4
nitrogen source Glycine 10 mM (N) N.D. +0.2 -0.2 -0.4 -0.6
nitrogen source L-Asparagine 10 mM (N) N.D. +0.2 -0.1 -0.0 -1.0
stress 7H9 with Meropenem 9.6 ug/mL N.D. -0.2 +0.1 -0.2 -0.6
nitrogen source Glycine 10 mM (N) N.D. -0.0 +0.1 -0.0 -0.9
stress 7H9 with para-aminosalicylic 0.086 ug/mL N.D. -0.6 +0.2 -0.0 -0.5
carbon source heptadecanoic 250 uM (C) N.D. +0.2 +0.1 -0.2 -0.9
carbon source butyrate 10 mM (C) N.D. +0.2 +0.0 -0.2 -0.9
nitrogen source L-Glutamic 10 mM (N) N.D. +0.3 -0.0 -0.1 -1.0
carbon source acetate (C) N.D. -0.4 +0.0 +0.1 -0.5
stress 7H9 with Dimethyl Sulfoxide 1 vol% N.D. +0.1 +0.1 -0.3 -0.7
stress 7H9 with Clofazimine 0.45 ug/mL N.D. +0.3 -0.2 +0.0 -0.8
carbon source Stearic 100 uM (C) N.D. +0.2 +0.1 -0.2 -0.8
stress 7H9 with Isoniazid 0.025 ug/mL N.D. -0.5 +0.1 -0.2 +0.4
stress 7H9 with Rifampicin 0.00045 ug/mL N.D. +0.1 +0.4 +0.0 -0.5
nitrogen source L-Glutamic 10 mM (N) N.D. +0.5 +0.2 -0.1 -0.5
stress 7H9 with Ofloxacin 0.8 ug/mL N.D. -0.3 +0.7 +0.0 +0.7
stress 7H9 with Ofloxacin 0.8 ug/mL N.D. -0.1 +0.5 +0.1 +0.6
stress 7H9 with Levofloxacin 0.3 ug/mL N.D. -0.7 +0.6 +0.3 +1.3
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