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Protein
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Fitness for 5 genes in
Mycobacterium tuberculosis H37Rv
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Number of genes on each side:
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Top 30 experiments (either direction), sorted by average fitness
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500 nt
Rv1321 and Rv1322 are separated by 22 nucleotides
Rv1322 and Rv1322A are separated by 34 nucleotides
Rv1322A and Rv1323 are separated by 90 nucleotides
Rv1323 and Rv1324 are separated by 129 nucleotides
Rv1321: Rv1321 - Conserved hypothetical protein, at 1,484,279 to 1,484,959
Rv1321
Rv1322: Rv1322 - Conserved hypothetical protein, at 1,484,982 to 1,485,278
Rv1322
Rv1322A: Rv1322A - Conserved protein, at 1,485,313 to 1,485,771
Rv1322A
Rv1323: Rv1323 - Probable acetyl-CoA acetyltransferase FadA4 (acetoacetyl-CoA thiolase), at 1,485,862 to 1,487,031
Rv1323
Rv1324: Rv1324 - Possible thioredoxin, at 1,487,161 to 1,488,075
Rv1324
Group
Condition
Rv1321
Rv1322
Rv1322A
Rv1323
Rv1324
stress
7H9 with Chlorhexidine diacetate salt 0.0021 mM
-0.1
-0.4
-0.5
-0.4
-1.7
stress
7H9 with Tetrazolium violet 0.065 mM
-0.0
-0.6
-0.2
-0.0
-1.9
stress
7H9 with Clarithromycin 0.967 ug/mL
-0.2
-1.8
-0.1
-0.0
-0.4
stress
7H9 with nitrate 4 mM
-0.4
-0.1
-0.4
-0.0
-1.6
stress
7H9 with Cumene hydroperoxide 0.05 mM
+0.1
+0.1
-0.1
+0.2
-2.5
stress
7H9 with Clarithromycin 0.967 ug/mL
+0.1
-1.6
+0.1
-0.0
-0.8
no stress control
no stress control
-0.1
+0.4
-0.5
-0.7
-1.1
stress
7H9 with nitrite 1.5 mM; pH 5.5
-0.3
+0.2
-0.3
-0.4
-1.1
stress
7H9 with Ciprofloxacin Hydrochloride 0.001 mM
+0.4
-0.2
-0.4
+0.4
-2.0
stress
7H9 with Phenazine methosulfate 0.0054 mM
+0.0
-0.1
-0.1
+0.4
-1.8
no stress control
no stress control
-0.1
+0.9
-0.0
-0.1
-2.1
stress
7H9 with Vancomycin Hydrochloride from Streptomyces orientalis 0.012 mM
+0.1
-0.5
+0.3
+0.1
-1.4
stress
7H9 with Chlorpromazine 0.054 mM
-0.3
+0.6
-0.2
-0.1
-1.2
carbon source
butyrate 10 mM (C)
+0.3
-0.0
+0.2
+0.1
-1.7
stress
7H9 with 2-bromo-2-nitro-1,3-propanediol 0.1 mM
-0.2
+0.6
+0.0
-0.2
-1.2
stress
7H9 with Dimethyl Sulfoxide 1 vol%
+0.2
+0.7
+0.0
-0.2
-1.7
stress
7H9 with Nickel (II) chloride 0.6 mM
-0.1
+0.7
-0.4
+0.2
-1.3
pH
pH 4.5
-0.2
+0.7
+0.4
+0.1
-1.7
stress
7H9 with nitrite 1.5 mM; pH 5.5
+0.1
+0.6
+0.1
-0.7
-0.8
no stress control
no stress control
+0.3
+0.5
+0.0
+0.3
-1.7
no stress control
no stress control
+0.2
+0.8
-0.7
-0.2
-0.6
stress
7H9 with 2-Mercaptopyridine N-oxide 0.0078 mM
-0.2
+1.1
-0.5
-0.7
+0.0
stress
7H9 with 8-hydroxy-nitroquinoline 0.03 mM
-0.3
+0.4
+0.4
+0.5
-1.1
stress
7H9 with Doxycycline hyclate 0.0035 mM
-0.1
+0.2
+0.4
+0.4
-1.0
stress
7H9 with Thioridazine 0.028 mM
-0.4
-0.3
-0.0
-0.6
+1.4
stress
7H9 with Ethionamide 0.1 ug/mL
-0.4
+0.4
+0.7
+0.5
-0.4
stress
7H9 with Isoniazid 0.025 ug/mL
-0.2
+0.8
+0.2
-0.5
+0.6
stress
7H9 with Dicloxacillin 0.0069 mM
+0.1
+0.3
+0.1
-0.3
+1.5
stress
7H9 with Irgasan 0.065 mM
-0.3
+0.4
-0.1
+0.2
+1.7
stress
7H9 with Chloramphenicol 0.01 mM
-0.0
+1.0
-0.1
+0.3
+1.4
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