Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv1321 and Rv1322 are separated by 22 nucleotidesRv1322 and Rv1322A are separated by 34 nucleotidesRv1322A and Rv1323 are separated by 90 nucleotidesRv1323 and Rv1324 are separated by 129 nucleotides Rv1321: Rv1321 - Conserved hypothetical protein, at 1,484,279 to 1,484,959 Rv1321 Rv1322: Rv1322 - Conserved hypothetical protein, at 1,484,982 to 1,485,278 Rv1322 Rv1322A: Rv1322A - Conserved protein, at 1,485,313 to 1,485,771 Rv1322A Rv1323: Rv1323 - Probable acetyl-CoA acetyltransferase FadA4 (acetoacetyl-CoA thiolase), at 1,485,862 to 1,487,031 Rv1323 Rv1324: Rv1324 - Possible thioredoxin, at 1,487,161 to 1,488,075 Rv1324
Group Condition Rv1321 Rv1322 Rv1322A Rv1323 Rv1324
stress 7H9 with Chlorhexidine diacetate salt 0.0021 mM -0.1 -0.4 -0.5 -0.4 -1.7
stress 7H9 with Tetrazolium violet 0.065 mM -0.0 -0.6 -0.2 -0.0 -1.9
stress 7H9 with Clarithromycin 0.967 ug/mL -0.2 -1.8 -0.1 -0.0 -0.4
stress 7H9 with nitrate 4 mM -0.4 -0.1 -0.4 -0.0 -1.6
stress 7H9 with Cumene hydroperoxide 0.05 mM +0.1 +0.1 -0.1 +0.2 -2.5
stress 7H9 with Clarithromycin 0.967 ug/mL +0.1 -1.6 +0.1 -0.0 -0.8
no stress control no stress control -0.1 +0.4 -0.5 -0.7 -1.1
stress 7H9 with nitrite 1.5 mM; pH 5.5 -0.3 +0.2 -0.3 -0.4 -1.1
stress 7H9 with Ciprofloxacin Hydrochloride 0.001 mM +0.4 -0.2 -0.4 +0.4 -2.0
stress 7H9 with Phenazine methosulfate 0.0054 mM +0.0 -0.1 -0.1 +0.4 -1.8
no stress control no stress control -0.1 +0.9 -0.0 -0.1 -2.1
stress 7H9 with Vancomycin Hydrochloride from Streptomyces orientalis 0.012 mM +0.1 -0.5 +0.3 +0.1 -1.4
stress 7H9 with Chlorpromazine 0.054 mM -0.3 +0.6 -0.2 -0.1 -1.2
carbon source butyrate 10 mM (C) +0.3 -0.0 +0.2 +0.1 -1.7
stress 7H9 with 2-bromo-2-nitro-1,3-propanediol 0.1 mM -0.2 +0.6 +0.0 -0.2 -1.2
stress 7H9 with Dimethyl Sulfoxide 1 vol% +0.2 +0.7 +0.0 -0.2 -1.7
stress 7H9 with Nickel (II) chloride 0.6 mM -0.1 +0.7 -0.4 +0.2 -1.3
pH pH 4.5 -0.2 +0.7 +0.4 +0.1 -1.7
stress 7H9 with nitrite 1.5 mM; pH 5.5 +0.1 +0.6 +0.1 -0.7 -0.8
no stress control no stress control +0.3 +0.5 +0.0 +0.3 -1.7
no stress control no stress control +0.2 +0.8 -0.7 -0.2 -0.6
stress 7H9 with 2-Mercaptopyridine N-oxide 0.0078 mM -0.2 +1.1 -0.5 -0.7 +0.0
stress 7H9 with 8-hydroxy-nitroquinoline 0.03 mM -0.3 +0.4 +0.4 +0.5 -1.1
stress 7H9 with Doxycycline hyclate 0.0035 mM -0.1 +0.2 +0.4 +0.4 -1.0
stress 7H9 with Thioridazine 0.028 mM -0.4 -0.3 -0.0 -0.6 +1.4
stress 7H9 with Ethionamide 0.1 ug/mL -0.4 +0.4 +0.7 +0.5 -0.4
stress 7H9 with Isoniazid 0.025 ug/mL -0.2 +0.8 +0.2 -0.5 +0.6
stress 7H9 with Dicloxacillin 0.0069 mM +0.1 +0.3 +0.1 -0.3 +1.5
stress 7H9 with Irgasan 0.065 mM -0.3 +0.4 -0.1 +0.2 +1.7
stress 7H9 with Chloramphenicol 0.01 mM -0.0 +1.0 -0.1 +0.3 +1.4
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