Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv1283c and Rv1284 are separated by 206 nucleotidesRv1284 and Rv1285 are separated by 93 nucleotidesRv1285 and Rv1286 overlap by 1 nucleotidesRv1286 and Rv1287 are separated by 53 nucleotides Rv1283c: Rv1283c - Probable oligopeptide-transport integral membrane protein ABC transporter OppB, at 1,436,140 to 1,437,117 Rv1283c Rv1284: Rv1284 - Beta-carbonic anhydrase, at 1,437,324 to 1,437,815 Rv1284 Rv1285: Rv1285 - Probable sulfate adenylyltransferase subunit 2 CysD, at 1,437,909 to 1,438,907 Rv1285 Rv1286: Rv1286 - Probable bifunctional enzyme CysN/CysC: sulfate adenyltransferase (subunit 1) + adenylylsulfate kinase, at 1,438,907 to 1,440,751 Rv1286 Rv1287: Rv1287 - Conserved hypothetical protein, at 1,440,805 to 1,441,290 Rv1287
Group Condition Rv1283c Rv1284 Rv1285 Rv1286 Rv1287
stress 7H9 with Hydrogen peroxide 2.5 mM; pH 5.5 -0.5 -4.0 N.D. -0.4 -0.5
stress 7H9 with Ethionamide 0.1 ug/mL -0.9 -3.2 N.D. -0.7 +0.5
no stress control no stress control +0.1 -4.1 N.D. +0.1 +0.2
stress 7H9 with Levofloxacin 0.3 ug/mL -0.2 -3.2 N.D. -0.6 +0.2
stress 7H9 with Econazole nitrate salt 0.0082 mM -0.7 -3.6 N.D. +0.3 +0.2
stress 7H9 with Hydrogen peroxide 2.5 mM; pH 6.5 -0.0 -3.9 N.D. +0.7 -0.1
stress 7H9 with Chloramphenicol 0.01 mM -0.0 -3.5 N.D. +0.3 -0.1
stress 7H9 with Thioridazine 0.028 mM -0.3 -2.0 N.D. -0.1 -0.5
stress 7H9 with Formaldehyde 0.23 mM -0.2 -2.0 N.D. -0.1 -0.5
stress 7H9 with Ofloxacin 0.8 ug/mL -0.8 -2.6 N.D. -0.2 +0.8
stress 7H9 with Isoniazid 0.025 ug/mL -0.3 -1.1 N.D. -0.5 -0.7
no stress control no stress control -0.1 -1.5 N.D. +0.0 -0.8
stress 7H9 with Ofloxacin 0.8 ug/mL -0.7 -1.5 N.D. -0.2 +0.2
stress 7H9 with Chloramphenicol 0.01 mM -0.6 -1.9 N.D. +0.6 -0.1
stress 7H9 with Dodecyl Sulfate 0.02 vol% -0.3 -1.9 N.D. +0.7 -0.5
stress 7H9 with Clofazimine 0.072 ug/mL -0.9 -1.6 N.D. +0.6 -0.1
stress 7H9 with Ethionamide 0.1 ug/mL +0.2 -1.6 N.D. -1.0 +0.6
stress 7H9 with Hydrogen peroxide 2.5 mM; pH 5.5 +0.4 -1.6 N.D. -0.0 -0.5
stress 7H9 with Pyrazinamide 50 ug/mL; pH 5.5 +0.3 -2.2 N.D. -0.1 +0.3
stress 7H9 with Rifampicin 0.014 ug/mL -1.1 +0.2 N.D. +0.8 -1.2
no stress control no stress control +0.4 -1.3 N.D. +0.3 -0.7
stress 7H9 with Pyrazinamide 50 ug/mL; pH 5.5 +0.3 -2.2 N.D. +0.6 +0.3
stress 7H9 with Ciprofloxacin Hydrochloride 0.0012 mM +0.2 -1.4 N.D. +0.7 -0.2
no stress control no stress control -0.1 -1.8 N.D. +0.6 +0.5
carbon source acetate (C) -0.4 +1.0 N.D. -1.0 -0.3
stress 7H9 with Rifampicin 0.014 ug/mL -1.1 +0.7 N.D. +0.8 -0.6
stress 7H9 with Hygromycin B 0.0095 mM -1.3 +1.3 N.D. +0.3 -0.3
stress 7H9 with Novobiocin 0.004 mM -1.0 +0.9 N.D. +1.1 -0.3
pH 7H9 pH 5.5 -0.2 +1.9 N.D. +0.3 +0.4
nitrogen source Urea 10mM (N) -0.1 +2.4 N.D. +0.7 +0.1
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