Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv1156 and Rv1157c are separated by 162 nucleotidesRv1157c and Rv1158c are separated by 7 nucleotidesRv1158c and Rv1159 are separated by 129 nucleotidesRv1159 and Rv1159A overlap by 4 nucleotides Rv1156: Rv1156 - Conserved protein, at 1,282,306 to 1,282,893 Rv1156 Rv1157c: Rv1157c - Conserved ala-, pro-rich protein, at 1,283,056 to 1,284,171 Rv1157c Rv1158c: Rv1158c - Conserved hypothetical ala-, pro-rich protein, at 1,284,179 to 1,284,862 Rv1158c Rv1159: Rv1159 - Mannosyltransferase PimE, at 1,284,992 to 1,286,287 Rv1159 Rv1159A: Rv1159A - Unknown protein, at 1,286,284 to 1,286,568 Rv1159A
Group Condition Rv1156 Rv1157c Rv1158c Rv1159 Rv1159A
stress 7H9 with Bedaquiline 0.15 ug/mL -0.3 N.D. -0.6 -4.4 -0.5
stress 7H9 with Bedaquiline 0.15 ug/mL -0.2 N.D. -0.3 -4.5 -0.1
stress 7H9 with Rifampicin 0.00045 ug/mL -0.3 N.D. -0.5 -2.3 -0.5
stress 7H9 with Clofazimine 0.072 ug/mL -0.2 N.D. -0.6 -2.4 +0.3
carbon source butyrate 10 mM (C) -0.2 N.D. +0.1 -3.0 +0.1
stress 7H9 with Ethambutol 0.75 ug/mL -0.1 N.D. -0.9 -1.5 -0.3
stress 7H9 with Clofazimine 0.072 ug/mL -0.2 N.D. -0.2 -2.1 -0.2
carbon source L-Asparagine (C) -0.2 N.D. +0.1 -2.2 -0.2
stress 7H9 with Clofazimine 0.45 ug/mL -0.1 N.D. +0.1 -2.4 +0.0
carbon source pyruvate (C) +0.0 N.D. -0.2 -2.3 +0.2
carbon source L-Aspartic Acid (C) -0.0 N.D. +0.2 -2.3 +0.1
carbon source butyrate 10 mM (C) -0.1 N.D. +0.5 -2.2 -0.1
stress 7H9 with Dimethyl Sulfoxide 1 vol% -0.0 N.D. +0.5 -1.9 -0.4
stress 7H9 with Isoniazid 0.025 ug/mL +0.1 N.D. +0.3 -2.5 +0.4
carbon source Stearic 100 uM (C) -0.2 N.D. +0.8 -2.5 +0.1
no stress control no stress control -0.3 N.D. -0.1 -1.7 +0.4
stress 7H9 with Meropenem 9.6 ug/mL -0.2 N.D. -0.9 -1.1 +0.5
carbon source L-Glutamine (C) +0.2 N.D. +0.4 -1.8 -0.2
carbon source Stearic 100 uM (C) -0.0 N.D. +0.8 -2.4 +0.6
no stress control no stress control -0.2 N.D. +1.0 -2.1 +0.4
nitrogen source L-Alanine 10 mM (N) -0.1 N.D. +1.0 -1.1 -0.7
stress 7H9 with Ethionamide 0.1 ug/mL -0.3 N.D. +1.1 -1.3 -0.3
nitrogen source Glycine 10 mM (N) -0.2 N.D. +1.5 -2.4 +0.5
no stress control no stress control -0.1 N.D. +1.1 -2.0 +0.5
nitrogen source Glycine 10 mM (N) -0.0 N.D. +0.9 -1.3 +0.2
nitrogen source L-Asparagine 10 mM (N) +0.1 N.D. +1.4 -1.3 -0.3
nitrogen source L-Glutamine 10 mM (N) +0.0 N.D. +1.3 -0.9 -0.3
nitrogen source L-Alanine 10 mM (N) +0.1 N.D. +1.0 -1.4 +0.5
no stress control no stress control +0.1 N.D. +1.4 -1.1 +0.3
stress 7H9 with para-aminosalicylic 0.086 ug/mL -0.3 N.D. +0.2 -0.7 +1.7
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