Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv1154c and Rv1155 overlap by 56 nucleotidesRv1155 and Rv1156 are separated by 433 nucleotidesRv1156 and Rv1157c are separated by 162 nucleotidesRv1157c and Rv1158c are separated by 7 nucleotides Rv1154c: Rv1154c - Hypothetical protein, at 1,280,843 to 1,281,484 Rv1154c Rv1155: Rv1155 - Possible pyridoxamine 5'-phosphate oxidase (PNP/PMP oxidase) (pyridoxinephosphate oxidase) (PNPOX) (pyridoxine 5'-phosphate oxidase), at 1,281,429 to 1,281,872 Rv1155 Rv1156: Rv1156 - Conserved protein, at 1,282,306 to 1,282,893 Rv1156 Rv1157c: Rv1157c - Conserved ala-, pro-rich protein, at 1,283,056 to 1,284,171 Rv1157c Rv1158c: Rv1158c - Conserved hypothetical ala-, pro-rich protein, at 1,284,179 to 1,284,862 Rv1158c
Group Condition Rv1154c Rv1155 Rv1156 Rv1157c Rv1158c
stress 7H9 with copper (II) chloride 0.08 mM +0.2 +0.1 -0.7 N.D. -0.8
pH pH 4.5 -0.2 -0.6 +0.1 N.D. -0.4
stress 7H9 with Menadione 0.005 mM -0.1 -1.3 -0.2 N.D. +0.4
stress 7H9 with Hydrogen peroxide 2.5 mM; pH 6.5 -0.0 +0.3 -0.1 N.D. -1.0
stress 7H9 with nitrate 4 mM -0.2 -0.1 -0.8 N.D. +0.3
stress 7H9 with Menadione 0.005 mM +0.1 -1.5 -0.0 N.D. +0.8
stress 7H9 with Levofloxacin 0.3 ug/mL -0.1 +0.4 +0.3 N.D. -1.2
stress 7H9 with Ethionamide 0.1 ug/mL -0.3 -0.6 -0.3 N.D. +1.1
stress 7H9 with Novobiocin 0.004 mM +0.0 -0.0 -0.8 N.D. +0.6
stress 7H9 with 2-Mercaptopyridine N-oxide 0.0078 mM +0.0 -0.5 -0.3 N.D. +0.9
no stress control no stress control -0.1 -0.4 -0.2 N.D. +0.8
stress 7H9 with 2-bromo-2-nitro-1,3-propanediol 0.1 mM -0.2 -0.3 -0.1 N.D. +0.8
no stress control no stress control +0.0 -0.3 -0.2 N.D. +1.0
stress 7H9 with Pretomanid 0.213 ug/mL +0.1 -0.2 -0.3 N.D. +0.9
stress 7H9 with Ciprofloxacin Hydrochloride 0.001 mM -0.1 -0.3 +0.2 N.D. +0.8
stress 7H9 with Linezolid 0.3 ug/mL -0.2 +0.3 -0.1 N.D. +0.8
carbon source heptadecanoic 250 uM (C) -0.2 -0.1 -0.1 N.D. +1.2
stress 7H9 with Pyrazinamide 50 ug/mL; pH 5.5 +0.0 +0.3 -0.3 N.D. +0.8
stress 7H9 with Benzethonium chloride 0.068 mM -0.1 +0.1 -0.1 N.D. +1.2
nitrogen source L-Alanine 10 mM (N) +0.2 -0.2 +0.1 N.D. +1.0
stress 7H9 with Spectinomycin 0.029 mM +0.2 -0.1 -0.1 N.D. +1.1
stress 7H9 with Spectinomycin 0.029 mM +0.2 +0.2 -0.1 N.D. +0.9
nitrogen source L-Glutamic 10 mM (N) +0.2 -0.0 -0.1 N.D. +1.0
no stress control no stress control +0.1 -0.3 +0.1 N.D. +1.4
stress 7H9 with Ciprofloxacin Hydrochloride 0.0012 mM +0.2 +0.2 -0.0 N.D. +1.0
nitrogen source Glycine 10 mM (N) +0.0 +0.0 -0.2 N.D. +1.6
stress 7H9 with Ciprofloxacin Hydrochloride 0.0012 mM +0.1 +0.1 +0.3 N.D. +0.9
no stress control no stress control +0.1 +0.1 +0.0 N.D. +1.1
nitrogen source L-Asparagine 10 mM (N) +0.2 +0.0 +0.2 N.D. +1.4
stress 7H9 with Dodecyl Sulfate 0.02 vol% +0.2 +0.9 -0.3 N.D. +0.9
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