Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv1145 and Rv1146 are separated by 20 nucleotidesRv1146 and Rv1147 are separated by 132 nucleotidesRv1147 and Rv1148c are separated by 749 nucleotidesRv1148c and Rv1149 are separated by 144 nucleotides Rv1145: Rv1145 - Probable conserved transmembrane transport protein MmpL13a, at 1,272,423 to 1,273,334 Rv1145 Rv1146: Rv1146 - Probable conserved transmembrane transport protein MmpL13b, at 1,273,355 to 1,274,767 Rv1146 Rv1147: Rv1147 - Conserved protein, at 1,274,900 to 1,275,550 Rv1147 Rv1148c: Rv1148c - Conserved hypothetical protein, at 1,276,300 to 1,277,748 Rv1148c Rv1149: Rv1149 - Possible transposase, at 1,277,893 to 1,278,300 Rv1149
Group Condition Rv1145 Rv1146 Rv1147 Rv1148c Rv1149
stress 7H9 with Irgasan 0.065 mM -0.0 +0.1 -0.2 -1.5 N.D.
stress 7H9 with Ethionamide 0.1 ug/mL -0.4 +0.0 -0.2 -0.6 N.D.
stress 7H9 with Hydrogen peroxide 2.5 mM; pH 6.5 -0.4 -0.1 +0.2 -0.8 N.D.
stress 7H9 with hypochlorite 0.4 vol% +0.2 -0.3 -0.0 -0.9 N.D.
stress 7H9 with 8-hydroxy-nitroquinoline 0.03 mM +0.0 +0.1 -0.3 -0.7 N.D.
stress 7H9 with Isoniazid 0.025 ug/mL -0.4 +0.1 -0.4 -0.2 N.D.
stress 7H9 with Isoniazid 0.025 ug/mL -0.4 +0.1 -0.2 -0.5 N.D.
stress 7H9 with Benzethonium chloride 0.068 mM -0.1 +0.1 -0.1 -0.8 N.D.
carbon source casaminos 1 mg/mL (C) +0.2 -0.1 -0.3 -0.7 N.D.
stress 7H9 with nitrite 1.5 mM; pH 5.5 +0.1 -0.0 +0.2 -1.1 N.D.
carbon source cholesterol 100uM (C) +0.2 +0.1 +0.2 -1.2 N.D.
stress 7H9 with Zinc Pyrithione 0.00072 mM -0.3 +0.0 +0.2 -0.6 N.D.
stress 7H9 with Formaldehyde 0.23 mM +0.2 +0.2 +0.0 -1.0 N.D.
carbon source oleate 200uM (C) +0.2 +0.1 -0.1 -0.7 N.D.
no stress control no stress control +0.2 +0.2 -0.0 -0.8 N.D.
stress 7H9 with Spectinomycin 0.029 mM +0.3 -0.0 +0.1 -0.8 N.D.
stress 7H9 with Clofazimine 0.45 ug/mL +0.3 +0.1 -0.0 -0.9 N.D.
stress 7H9 with Phenazine methosulfate 0.0054 mM +0.6 -0.1 +0.2 -1.1 N.D.
stress 7H9 with Econazole nitrate salt 0.0082 mM -0.5 -0.1 -0.2 +0.6 N.D.
no stress control no stress control +0.5 -0.2 -0.1 -0.5 N.D.
stress 7H9 with Sutezolid 0.12 ug/mL +0.5 +0.1 +0.0 -0.6 N.D.
pH 7H9 pH 5.5 +0.3 +0.1 +0.2 -0.5 N.D.
pH pH 4.5 -0.7 +0.2 +0.7 +0.2 N.D.
stress 7H9 with Geneticin G418 0.35 mM +0.2 -0.2 -0.2 +0.6 N.D.
no stress control no stress control -0.0 +0.2 -0.3 +0.6 N.D.
stress 7H9 with Linezolid 0.44 ug/mL -0.3 -0.0 +0.2 +0.7 N.D.
no stress control no stress control +0.5 -0.2 +0.1 +0.4 N.D.
no stress control no stress control -0.2 -0.1 -0.2 +1.3 N.D.
no stress control no stress control +0.1 +0.0 -0.2 +0.8 N.D.
stress 7H9 with Linezolid 0.3 ug/mL +0.3 +0.2 +0.2 +0.5 N.D.
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