Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv1140 and Rv1141c are separated by 7 nucleotidesRv1141c and Rv1142c are separated by 142 nucleotidesRv1142c and Rv1143 are separated by 103 nucleotidesRv1143 and Rv1144 are separated by 11 nucleotides Rv1140: Rv1140 - Probable integral membrane protein, at 1,267,347 to 1,268,195 Rv1140 Rv1141c: Rv1141c - Probable enoyl-CoA hydratase EchA11 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase), at 1,268,203 to 1,269,009 Rv1141c Rv1142c: Rv1142c - Probable enoyl-CoA hydratase EchA10 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase), at 1,269,152 to 1,269,958 Rv1142c Rv1143: Rv1143 - Probable alpha-methylacyl-CoA racemase Mcr (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase), at 1,270,062 to 1,271,144 Rv1143 Rv1144: Rv1144 - Probable short-chain type dehydrogenase/reductase, at 1,271,156 to 1,271,908 Rv1144
Group Condition Rv1140 Rv1141c Rv1142c Rv1143 Rv1144
carbon source D-Trehalose 10 mM (C) -0.5 -0.0 -0.3 -0.1 +0.1
carbon source pyruvate (C) -0.6 -0.1 -0.1 -0.0 +0.1
stress 7H9 with Rifampicin 0.00045 ug/mL -0.3 +0.2 +0.0 +0.2 -0.4
carbon source heptadecanoic 250 uM (C) -0.4 +0.1 -0.3 +0.1 +0.1
no stress control no stress control -0.3 -0.3 +0.2 +0.2 -0.0
stress 7H9 with Streptomycin 0.178 ug/mL +0.4 -0.4 +0.1 +0.0 -0.3
carbon source casaminos 1 mg/mL (C) -0.3 +0.4 -0.2 -0.0 -0.1
carbon source D-Lactate 10 mM (C) -0.3 -0.1 -0.1 -0.1 +0.5
stress 7H9 with Linezolid 0.44 ug/mL -0.5 +0.2 +0.2 +0.1 +0.1
stress 7H9 with Dimethyl Sulfoxide 1 vol% +0.4 +0.2 -0.3 -0.1 -0.2
nitrogen source L-Serine 10 mM (N) +0.2 -0.2 -0.3 -0.0 +0.4
carbon source L-Lactate 10 mM (C) -0.2 +0.3 -0.2 -0.1 +0.3
carbon source L-Lactate 10 mM (C) -0.1 +0.5 -0.3 -0.1 +0.2
carbon source casaminos 1 mg/mL (C) -0.4 +0.3 -0.1 -0.1 +0.5
stress 7H9 with para-aminosalicylic 0.086 ug/mL +0.4 -0.3 +0.2 +0.1 -0.2
stress 7H9 with Isoniazid 0.025 ug/mL +0.3 +0.2 +0.1 +0.2 -0.6
stress 7H9 with Rifampicin 0.014 ug/mL -0.2 +0.3 +0.1 +0.2 -0.2
no stress control no stress control +0.2 +0.2 +0.0 +0.2 -0.3
nitrogen source L-Valine 10 mM (N) -0.1 -0.3 +0.3 +0.1 +0.3
nitrogen source Glycine 10 mM (N) +0.5 +0.2 -0.2 +0.1 -0.0
stress 7H9 with Streptomycin 0.178 ug/mL +0.4 -0.2 +0.2 +0.2 -0.0
stress 7H9 with Ethionamide 0.1 ug/mL +0.6 -0.1 +0.1 -0.2 +0.3
stress 7H9 with Ethionamide 0.1 ug/mL +0.7 -0.4 -0.1 +0.2 +0.2
stress 7H9 with Isoniazid 0.025 ug/mL +0.6 -0.1 +0.1 +0.0 +0.2
stress 7H9 with Sulfaquinoxaline 0.097 mM +0.5 +0.2 +0.1 -0.1 +0.0
stress 7H9 with Delamanid 0.236 ug/mL +0.5 -0.2 +0.3 +0.3 -0.1
stress 7H9 with Levofloxacin 0.3 ug/mL +0.5 +0.1 +0.2 +0.3 -0.1
stress 7H9 with Clarithromycin 0.967 ug/mL +0.7 -0.2 +0.4 +0.3 -0.1
stress 7H9 with Meropenem 9.6 ug/mL +0.7 -0.1 +0.2 +0.1 +0.1
stress 7H9 with Meropenem 9.6 ug/mL +0.3 +0.3 +0.2 -0.0 +0.5
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