Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv1086 and Rv1087 are separated by 176 nucleotidesRv1087 and Rv1087A are separated by 176 nucleotidesRv1087A and Rv1088 are separated by 152 nucleotidesRv1088 and Rv1089 overlap by 179 nucleotides Rv1086: Rv1086 - Short (C15) chain Z-isoprenyl diphosphate synthase (Z-FPP synthase) (Z-farnesyl diphosphate synthase) (Z-FPP synthetase) (Z-farnesyl diphosphate synthetase) (geranyltranstransferase) (farnesyl pyrophosphate synthetase), at 1,210,595 to 1,211,383 Rv1086 Rv1087: Rv1087 - PE-PGRS family protein PE_PGRS21, at 1,211,560 to 1,213,863 Rv1087 Rv1087A: Rv1087A - Conserved hypothetical protein, at 1,214,040 to 1,214,360 Rv1087A Rv1088: Rv1088 - PE family protein PE9, at 1,214,513 to 1,214,947 Rv1088 Rv1089: Rv1089 - PE family protein PE10, at 1,214,769 to 1,215,131 Rv1089
Group Condition Rv1086 Rv1087 Rv1087A Rv1088 Rv1089
stress 7H9 with Ethambutol 0.75 ug/mL N.D. -0.5 -0.7 -0.9 N.D.
no stress control no stress control N.D. -0.7 -0.7 -0.7 N.D.
carbon source L-Asparagine (C) N.D. -0.6 -0.8 -0.5 N.D.
stress 7H9 with Dimethyl Sulfoxide 1 vol% N.D. -0.4 -0.6 -0.9 N.D.
stress 7H9 with para-aminosalicylic 0.086 ug/mL N.D. -0.4 -0.6 -0.7 N.D.
carbon source L-Asparagine (C) N.D. -0.7 -0.4 -0.6 N.D.
carbon source L-Aspartic Acid (C) N.D. -0.5 -0.6 -0.6 N.D.
no stress control no stress control N.D. -0.6 -0.8 -0.2 N.D.
stress 7H9 with Bedaquiline 0.15 ug/mL N.D. -0.5 -0.6 -0.3 N.D.
stress 7H9 with Sulfamethizole 0.026 mM N.D. -0.1 -0.5 -0.7 N.D.
stress 7H9 with Bedaquiline 0.15 ug/mL N.D. -0.4 -0.5 -0.4 N.D.
stress 7H9 with Meropenem 9.6 ug/mL N.D. -0.2 -0.4 -0.5 N.D.
carbon source L-Glutamine (C) N.D. +0.3 +0.3 +0.6 N.D.
carbon source heptadecanoic 250 uM (C) N.D. +0.3 +0.4 +0.4 N.D.
no stress control no stress control N.D. +0.6 +0.2 +0.6 N.D.
carbon source heptadecanoic 250 uM (C) N.D. +0.3 +0.3 +0.7 N.D.
carbon source Palmitic 100 uM (C) N.D. +0.3 +0.5 +0.6 N.D.
carbon source Valeric 10 mM (C) N.D. +0.3 +0.6 +0.6 N.D.
carbon source Palmitic 100 uM (C) N.D. +0.3 +0.4 +0.9 N.D.
stress 7H9 with Ofloxacin 0.8 ug/mL N.D. +1.0 +0.6 +0.3 N.D.
no stress control no stress control N.D. +0.7 +0.6 +0.7 N.D.
stress 7H9 with Ethionamide 0.1 ug/mL N.D. +1.1 +0.4 +0.6 N.D.
stress 7H9 with Ofloxacin 0.8 ug/mL N.D. +1.0 +0.8 +0.4 N.D.
stress 7H9 with Isoniazid 0.025 ug/mL N.D. +1.2 +0.9 +0.8 N.D.
stress 7H9 with Isoniazid 0.025 ug/mL N.D. +1.1 +0.8 +0.9 N.D.
stress 7H9 with Moxifloxacin 0.121 ug/mL N.D. +1.2 +1.1 +0.6 N.D.
stress 7H9 with Streptomycin 0.178 ug/mL N.D. +1.1 +0.8 +1.1 N.D.
stress 7H9 with Moxifloxacin 0.121 ug/mL N.D. +1.2 +0.8 +1.1 N.D.
no stress control no stress control N.D. +1.4 +1.0 +0.7 N.D.
stress 7H9 with Levofloxacin 0.3 ug/mL N.D. +1.4 +1.0 +0.8 N.D.
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