Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv1083 and Rv1084 overlap by 14 nucleotidesRv1084 and Rv1085c are separated by 98 nucleotidesRv1085c and Rv1086 are separated by 110 nucleotidesRv1086 and Rv1087 are separated by 176 nucleotides Rv1083: Rv1083 - Conserved hypothetical protein, at 1,207,383 to 1,207,649 Rv1083 Rv1084: Rv1084 - Conserved protein, at 1,207,636 to 1,209,657 Rv1084 Rv1085c: Rv1085c - Possible hemolysin-like protein, at 1,209,756 to 1,210,484 Rv1085c Rv1086: Rv1086 - Short (C15) chain Z-isoprenyl diphosphate synthase (Z-FPP synthase) (Z-farnesyl diphosphate synthase) (Z-FPP synthetase) (Z-farnesyl diphosphate synthetase) (geranyltranstransferase) (farnesyl pyrophosphate synthetase), at 1,210,595 to 1,211,383 Rv1086 Rv1087: Rv1087 - PE-PGRS family protein PE_PGRS21, at 1,211,560 to 1,213,863 Rv1087
Group Condition Rv1083 Rv1084 Rv1085c Rv1086 Rv1087
stress 7H9 with nitrate 4 mM N.D. -0.5 -1.3 N.D. -1.3
nitrogen source L-Asparagine 10 mM (N) N.D. -0.1 -1.8 N.D. -0.2
carbon source propionate (C) N.D. +0.1 -2.0 N.D. -0.3
stress 7H9 with Geneticin G418 0.35 mM N.D. -0.2 -1.2 N.D. -0.6
carbon source propionate (C) N.D. -0.1 -1.9 N.D. +0.2
stress 7H9 with Sisomicin 0.07 mM N.D. +0.1 -1.0 N.D. -0.8
stress 7H9 with Phenazine ethosulfate 0.0137 mM N.D. -0.4 -0.5 N.D. -0.9
nitrogen source Ammonium chloride 10mM (N) N.D. -0.2 -1.1 N.D. -0.3
nitrogen source Ammonium chloride 10mM (N) N.D. +0.1 -1.3 N.D. -0.3
carbon source L-Asparagine (C) N.D. +0.0 -0.8 N.D. -0.7
carbon source Stearic 100 uM (C) N.D. +0.1 -1.5 N.D. +0.2
carbon source Glycerol (C) N.D. +0.1 -1.5 N.D. +0.3
carbon source Glycerol (C) N.D. +0.1 -1.4 N.D. +0.3
nitrogen source L-Asparagine 10 mM (N) N.D. +0.1 -1.3 N.D. +0.3
carbon source Stearic 100 uM (C) N.D. +0.2 -1.3 N.D. +0.2
nitrogen source L-Valine 10 mM (N) N.D. +0.2 -1.2 N.D. +0.3
pH pH 5.5 N.D. +0.3 +0.7 N.D. +0.6
stress 7H9 with nitrite 3 mM; pH 5.5 N.D. +0.5 +0.6 N.D. +0.5
no stress control no stress control N.D. +0.6 +0.5 N.D. +0.6
stress 7H9 with Ciprofloxacin Hydrochloride 0.001 mM N.D. +0.7 +0.4 N.D. +0.6
stress 7H9 with Ethionamide 0.1 ug/mL N.D. +0.3 +0.4 N.D. +1.1
stress 7H9 with Isoniazid 0.025 ug/mL N.D. +0.3 +0.3 N.D. +1.1
stress 7H9 with Isoniazid 0.025 ug/mL N.D. +0.1 +0.6 N.D. +1.2
stress 7H9 with Ofloxacin 0.8 ug/mL N.D. +0.6 +0.5 N.D. +1.0
stress 7H9 with Streptomycin 0.178 ug/mL N.D. +0.4 +0.7 N.D. +1.1
stress 7H9 with Moxifloxacin 0.121 ug/mL N.D. +0.5 +0.6 N.D. +1.2
no stress control no stress control N.D. +0.3 +0.7 N.D. +1.3
stress 7H9 with Moxifloxacin 0.121 ug/mL N.D. +0.7 +0.7 N.D. +1.2
no stress control no stress control N.D. +0.5 +0.8 N.D. +1.4
stress 7H9 with Levofloxacin 0.3 ug/mL N.D. +0.8 +0.9 N.D. +1.4
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