Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv1072 and Rv1073 are separated by 115 nucleotidesRv1073 and Rv1074c are separated by 73 nucleotidesRv1074c and Rv1075c are separated by 52 nucleotidesRv1075c and Rv1076 are separated by 396 nucleotides Rv1072: Rv1072 - Probable conserved transmembrane protein, at 1,196,279 to 1,197,115 Rv1072 Rv1073: Rv1073 - Conserved hypothetical protein, at 1,197,231 to 1,198,082 Rv1073 Rv1074c: Rv1074c - Probable beta-ketoacyl CoA thiolase FadA3, at 1,198,156 to 1,199,373 Rv1074c Rv1075c: Rv1075c - Conserved exported protein, at 1,199,426 to 1,200,370 Rv1075c Rv1076: Rv1076 - Possible lipase LipU, at 1,200,767 to 1,201,660 Rv1076
Group Condition Rv1072 Rv1073 Rv1074c Rv1075c Rv1076
no stress control no stress control -2.7 -0.1 +0.0 -0.3 -0.2
stress 7H9 with Meropenem 9.6 ug/mL -2.6 -0.0 +0.1 +0.1 +0.1
stress 7H9 with Dimethyl Sulfoxide 1 vol% -1.9 -0.0 +0.0 -0.0 -0.1
stress 7H9 with Hygromycin B 0.0095 mM -1.9 +0.0 +0.1 -0.1 +0.0
nitrogen source L-Asparagine 10 mM (N) -1.8 -0.0 +0.1 -0.2 -0.0
nitrogen source L-Alanine 10 mM (N) -1.8 -0.1 +0.1 +0.0 -0.0
carbon source L-Asparagine (C) -1.5 -0.1 -0.1 +0.1 -0.1
nitrogen source L-Serine 10 mM (N) -1.8 +0.1 +0.1 +0.0 +0.0
carbon source propionate (C) -1.6 -0.1 +0.1 +0.1 -0.0
carbon source heptadecanoic 250 uM (C) -1.2 -0.1 -0.0 -0.2 +0.1
stress 7H9 with Ofloxacin 0.8 ug/mL -2.3 +0.3 +0.2 +0.3 +0.2
nitrogen source L-Serine 10 mM (N) -1.3 -0.2 +0.2 -0.1 +0.2
carbon source Glycerol (C) -1.3 -0.1 +0.2 +0.1 -0.0
stress 7H9 with Delamanid 0.236 ug/mL -1.7 +0.2 +0.2 +0.1 -0.0
stress 7H9 with Hygromycin B 0.0095 mM -1.5 +0.1 +0.1 -0.0 +0.1
nitrogen source L-Glutamine 10 mM (N) -1.2 +0.0 +0.2 +0.1 -0.1
stress 7H9 with Streptomycin 0.178 ug/mL -1.8 +0.2 +0.5 +0.2 +0.1
carbon source Valeric 10 mM (C) -1.2 +0.0 +0.2 +0.1 +0.2
stress 7H9 with Isoniazid 0.025 ug/mL -2.1 +0.5 +0.4 +0.2 +0.4
stress 7H9 with Ethionamide 0.1 ug/mL -1.5 +0.3 +0.4 -0.1 +0.3
stress 7H9 with Ethionamide 0.1 ug/mL -1.6 +0.5 +0.4 +0.2 +0.2
stress 7H9 with Streptomycin 0.178 ug/mL -1.7 +0.5 +0.6 +0.3 +0.3
stress 7H9 with Ofloxacin 0.8 ug/mL -1.1 +0.4 +0.3 +0.2 +0.3
stress 7H9 with Isoniazid 0.025 ug/mL -1.7 +0.6 +0.5 +0.4 +0.5
stress 7H9 with Moxifloxacin 0.121 ug/mL -0.7 +0.5 +0.2 +0.2 +0.4
no stress control no stress control -1.1 +0.7 +0.4 +0.4 +0.4
stress 7H9 with Clarithromycin 0.967 ug/mL +1.6 -0.1 -0.1 -0.1 -0.3
stress 7H9 with Levofloxacin 0.3 ug/mL -1.0 +0.7 +0.5 +0.4 +0.5
stress 7H9 with para-aminosalicylic 0.086 ug/mL +0.4 +0.3 +0.4 +0.1 +0.5
stress 7H9 with Moxifloxacin 0.121 ug/mL -0.1 +0.5 +0.3 +0.4 +0.5
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