Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv0974c and Rv0975c are separated by 2 nucleotidesRv0975c and Rv0976c overlap by 4 nucleotidesRv0976c and Rv0977 are separated by 197 nucleotidesRv0977 and Rv0978c are separated by 216 nucleotides Rv0974c: Rv0974c - Probable acetyl-/propionyl-CoA carboxylase (beta subunit) AccD2, at 1,085,756 to 1,087,345 Rv0974c Rv0975c: Rv0975c - Probable acyl-CoA dehydrogenase FadE13, at 1,087,348 to 1,088,496 Rv0975c Rv0976c: Rv0976c - Conserved hypothetical protein, at 1,088,493 to 1,090,175 Rv0976c Rv0977: Rv0977 - PE-PGRS family protein PE_PGRS16, at 1,090,373 to 1,093,144 Rv0977 Rv0978c: Rv0978c - PE-PGRS family protein PE_PGRS17, at 1,093,361 to 1,094,356 Rv0978c
Group Condition Rv0974c Rv0975c Rv0976c Rv0977 Rv0978c
stress 7H9 with Ethambutol 0.75 ug/mL -0.1 -0.1 -0.0 -0.1 -0.9
nitrogen source L-Valine 10 mM (N) +0.3 -0.5 -0.2 -0.2 +0.1
carbon source Palmitic 100 uM (C) +0.3 -0.1 +0.0 +0.0 -0.8
carbon source D-Trehalose 10 mM (C) +0.2 +0.3 -0.4 +0.1 -0.6
stress 7H9 with Sulfamethizole 0.026 mM +0.4 -0.6 -0.3 -0.0 -0.0
stress 7H9 with Sulfamethizole 0.026 mM +0.6 -0.1 -0.2 -0.0 -0.5
carbon source D-Trehalose 10 mM (C) -0.1 +0.4 -0.3 +0.1 -0.3
nitrogen source Glycine 10 mM (N) +0.5 -0.2 -0.3 +0.1 -0.0
carbon source Stearic 100 uM (C) +0.4 +0.1 +0.1 +0.1 -0.6
carbon source heptadecanoic 250 uM (C) +0.3 -0.2 +0.3 +0.2 -0.4
stress 7H9 with Streptomycin 0.178 ug/mL +0.3 +0.4 -0.2 +0.2 -0.4
nitrogen source L-Glutamine 10 mM (N) +0.8 -0.1 -0.1 +0.0 -0.1
no stress control no stress control +1.0 -0.1 -0.2 +0.2 -0.4
carbon source D-Lactate 10 mM (C) -0.2 +0.2 -0.1 +0.2 +0.4
nitrogen source L-Glutamic 10 mM (N) +0.8 +0.1 -0.3 -0.1 +0.1
stress 7H9 with Clarithromycin 0.967 ug/mL +0.4 +0.4 +0.2 +0.2 -0.6
nitrogen source L-Aspartic Acid 10 mM (N) +0.6 -0.1 -0.3 +0.1 +0.3
stress 7H9 with Meropenem 9.6 ug/mL +0.9 +0.0 +0.2 -0.1 -0.2
stress 7H9 with Hygromycin B 0.0095 mM +0.5 -0.1 -0.1 +0.1 +0.4
nitrogen source L-Asparagine 10 mM (N) +0.5 -0.2 -0.0 +0.1 +0.4
no stress control no stress control +0.6 +0.5 -0.0 +0.1 -0.4
nitrogen source L-Aspartic Acid 10 mM (N) +0.5 +0.1 -0.1 -0.0 +0.4
stress 7H9 with Moxifloxacin 0.121 ug/mL +0.5 +0.1 -0.2 +0.2 +0.5
stress 7H9 with Delamanid 0.236 ug/mL +0.6 +0.4 +0.1 +0.0 -0.1
stress 7H9 with Clarithromycin 0.967 ug/mL +0.8 +0.5 +0.2 +0.0 -0.4
carbon source L-Aspartic Acid (C) +0.1 +0.2 +0.2 +0.1 +0.5
no stress control no stress control +0.8 +0.0 +0.1 +0.1 +0.3
no stress control no stress control +0.6 +0.1 +0.4 -0.1 +0.4
stress 7H9 with Ethionamide 0.1 ug/mL +0.3 +0.6 +0.5 +0.3 -0.1
stress 7H9 with Isoniazid 0.025 ug/mL +0.6 +0.3 -0.2 +0.3 +0.6
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