Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv0801 and Rv0802c overlap by 7 nucleotidesRv0802c and Rv0803 are separated by 191 nucleotidesRv0803 and Rv0804 overlap by 4 nucleotidesRv0804 and Rv0805 are separated by 120 nucleotides Rv0801: Rv0801 - Conserved protein, at 894,631 to 894,978 Rv0801 Rv0802c: Rv0802c - Possible succinyltransferase in the GCN5-related N-acetyltransferase family, at 894,972 to 895,628 Rv0802c Rv0803: Rv0803 - Phosphoribosylformylglycinamidine synthase II PurL (FGAM synthase II), at 895,820 to 898,084 Rv0803 Rv0804: Rv0804 - Conserved hypothetical protein, at 898,081 to 898,710 Rv0804 Rv0805: Rv0805 - Class III cyclic nucleotide phosphodiesterase (cNMP PDE), at 898,831 to 899,787 Rv0805
Group Condition Rv0801 Rv0802c Rv0803 Rv0804 Rv0805
stress 7H9 with Ethionamide 0.1 ug/mL N.D. -0.6 N.D. +0.0 -2.0
stress 7H9 with Sisomicin 0.07 mM N.D. +0.5 N.D. -0.1 -2.7
carbon source casaminos 1 mg/mL (C) N.D. +0.3 N.D. -0.1 -2.4
carbon source Valeric 10 mM (C) N.D. +0.1 N.D. -0.1 -2.1
stress 7H9 with Hygromycin B 0.0095 mM N.D. -0.1 N.D. -0.1 -1.9
stress 7H9 with Doxycycline hyclate 0.0035 mM N.D. +0.0 N.D. +0.0 -2.1
stress 7H9 with Clarithromycin 0.967 ug/mL N.D. -0.2 N.D. +0.1 -1.7
no stress control no stress control N.D. +0.1 N.D. -0.1 -1.8
stress 7H9 with Pretomanid 0.213 ug/mL N.D. +0.1 N.D. +0.1 -1.8
no stress control no stress control N.D. +0.2 N.D. -0.2 -1.6
carbon source propionate (C) N.D. +0.2 N.D. +0.1 -1.8
stress 7H9 with Ofloxacin 0.8 ug/mL N.D. -0.1 N.D. +0.3 -1.6
nitrogen source Ammonium chloride 10mM (N) N.D. -0.0 N.D. +0.8 -1.6
nitrogen source Ammonium chloride 10mM (N) N.D. +0.4 N.D. +0.7 -1.1
stress 7H9 with EDTA (disodium salt) 0.2 mM N.D. -0.5 N.D. +0.1 +1.3
stress 7H9 with Dicloxacillin 0.0069 mM N.D. -0.2 N.D. -0.4 +1.5
stress 7H9 with Dicloxacillin 0.0069 mM N.D. -0.3 N.D. -0.4 +1.6
stress 7H9 with 2-Mercaptopyridine N-oxide 0.0078 mM N.D. -0.2 N.D. -0.2 +1.5
stress 7H9 with Lomefloxacin 0.0035 mM N.D. -0.1 N.D. -0.4 +1.7
stress 7H9 with Chloramphenicol 0.01 mM N.D. -0.3 N.D. -0.1 +1.6
no stress control no stress control N.D. -0.5 N.D. -0.1 +2.0
stress 7H9 with Cloxacillin 0.0386 mM N.D. +0.0 N.D. -0.3 +1.7
stress 7H9 with Rifampicin 0.00045 ug/mL N.D. -0.1 N.D. +0.2 +1.6
stress 7H9 with Hydrogen peroxide 2.5 mM; pH 5.5 N.D. -0.2 N.D. -0.2 +2.2
stress 7H9 with Antimycin A 0.0186 mM N.D. -0.1 N.D. -0.1 +2.0
stress 7H9 with Ceftriaxone hemi(heptahydrate) 0.12 mM N.D. +0.0 N.D. -0.1 +2.0
carbon source oleate 200uM (C) N.D. +0.3 N.D. +0.6 +1.0
pH pH 5.5 N.D. -0.7 N.D. +0.3 +2.3
stress 7H9 with Linezolid 0.44 ug/mL N.D. +0.2 N.D. -0.5 +2.2
stress 7H9 with Cloxacillin 0.0386 mM N.D. -0.1 N.D. -0.2 +2.5
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