Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv0787A and Rv0788 overlap by 4 nucleotidesRv0788 and Rv0789c are separated by 16 nucleotidesRv0789c and Rv0790c are separated by 21 nucleotidesRv0790c and Rv0791c overlap by 4 nucleotides Rv0787A: Rv0787A - Conserved protein, at 882,524 to 882,763 Rv0787A Rv0788: Rv0788 - Probable phosphoribosylformylglycinamidine synthase I PURG (FGAM synthase I), at 882,760 to 883,434 Rv0788 Rv0789c: Rv0789c - Hypothetical protein, at 883,451 to 884,050 Rv0789c Rv0790c: Rv0790c - Hypothetical protein, at 884,072 to 884,800 Rv0790c Rv0791c: Rv0791c - Conserved protein, at 884,797 to 885,840 Rv0791c
Group Condition Rv0787A Rv0788 Rv0789c Rv0790c Rv0791c
carbon source butyrate 10 mM (C) N.D. N.D. +0.3 -0.2 -0.3
no stress control no stress control N.D. N.D. +0.4 -0.1 -0.3
stress 7H9 with Delamanid 0.236 ug/mL N.D. N.D. +0.4 +0.0 -0.3
stress 7H9 with Ethionamide 0.1 ug/mL N.D. N.D. +0.3 -0.3 +0.2
carbon source Stearic 100 uM (C) N.D. N.D. +0.5 -0.4 -0.0
stress 7H9 with Ethionamide 0.1 ug/mL N.D. N.D. +0.2 -0.3 +0.3
stress 7H9 with Isoniazid 0.025 ug/mL N.D. N.D. -0.1 -0.3 +0.5
stress 7H9 with Bedaquiline 0.15 ug/mL N.D. N.D. +0.6 -0.2 -0.1
carbon source L-Lactate 10 mM (C) N.D. N.D. +0.5 -0.2 +0.1
stress 7H9 with Clofazimine 0.072 ug/mL N.D. N.D. +0.6 +0.0 -0.3
stress 7H9 with Rifampicin 0.014 ug/mL N.D. N.D. +0.7 +0.0 -0.2
stress 7H9 with Pretomanid 0.213 ug/mL N.D. N.D. +0.5 +0.2 -0.1
stress 7H9 with Dimethyl Sulfoxide 1 vol% N.D. N.D. +0.7 -0.1 -0.0
no stress control no stress control N.D. N.D. +0.8 -0.2 +0.1
carbon source L-Asparagine (C) N.D. N.D. +0.4 -0.0 +0.4
stress 7H9 with Isoniazid 0.025 ug/mL N.D. N.D. +0.2 +0.2 +0.4
stress 7H9 with Delamanid 0.236 ug/mL N.D. N.D. +0.8 -0.0 +0.1
stress 7H9 with Bedaquiline 0.15 ug/mL N.D. N.D. +0.4 +0.1 +0.3
stress 7H9 with Meropenem 9.6 ug/mL N.D. N.D. +0.6 +0.1 +0.1
stress 7H9 with Clofazimine 0.45 ug/mL N.D. N.D. +0.6 +0.4 -0.1
carbon source L-Glutamine (C) N.D. N.D. +0.4 +0.1 +0.5
stress 7H9 with Dimethyl Sulfoxide 1 vol% N.D. N.D. +0.8 -0.0 +0.2
stress 7H9 with Rifampicin 0.00045 ug/mL N.D. N.D. +0.5 +0.2 +0.2
nitrogen source L-Asparagine 10 mM (N) N.D. N.D. +0.7 -0.1 +0.4
stress 7H9 with Rifampicin 0.014 ug/mL N.D. N.D. +0.7 +0.2 +0.1
nitrogen source L-Glutamine 10 mM (N) N.D. N.D. +0.6 -0.0 +0.5
nitrogen source L-Glutamic 10 mM (N) N.D. N.D. +0.6 +0.1 +0.7
nitrogen source L-Glutamic 10 mM (N) N.D. N.D. +0.7 +0.0 +0.7
nitrogen source Glycine 10 mM (N) N.D. N.D. +1.0 +0.2 +0.4
nitrogen source L-Glutamine 10 mM (N) N.D. N.D. +0.8 +0.1 +0.7
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