Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv0755A and GFF789 are separated by 114 nucleotidesGFF789 and Rv0756c are separated by 27 nucleotidesRv0756c and Rv0757 are separated by 141 nucleotidesRv0757 and Rv0758 are separated by 44 nucleotides Rv0755A: Rv0755A - Putative transposase (fragment), at 850,342 to 850,527 Rv0755A GFF789 - tRNA-Thr, at 850,642 to 850,713 GFF789 Rv0756c: Rv0756c - Unknown protein, at 850,741 to 851,466 Rv0756c Rv0757: Rv0757 - Possible two component system response transcriptional positive regulator PhoP, at 851,608 to 852,351 Rv0757 Rv0758: Rv0758 - Possible two component system response sensor kinase membrane associated PhoR, at 852,396 to 853,853 Rv0758
Group Condition Rv0755A GFF789 Rv0756c Rv0757 Rv0758
carbon source propionate (C) -0.2 N.D. -0.5 -1.4 -3.9
stress 7H9 with Bedaquiline 0.15 ug/mL -0.1 N.D. -0.1 -3.0 -1.7
stress 7H9 with Clofazimine 0.45 ug/mL -0.2 N.D. -0.1 -3.8 -0.4
stress 7H9 with Clofazimine 0.072 ug/mL -0.1 N.D. +0.1 -3.0 -1.0
carbon source Glycerol (C) -0.0 N.D. -0.1 -1.1 -2.7
carbon source propionate (C) +0.2 N.D. -0.1 -2.0 -2.0
stress 7H9 with Bedaquiline 0.15 ug/mL +0.1 N.D. -0.2 -2.0 -1.5
carbon source L-Asparagine (C) +0.0 N.D. -0.0 -1.3 -2.0
stress 7H9 with Rifampicin 0.00045 ug/mL -0.2 N.D. +0.0 -2.3 -0.8
carbon source Glycerol (C) -0.0 N.D. -0.2 -1.2 -1.9
carbon source acetate (C) -0.2 N.D. -0.2 -2.2 -0.7
stress 7H9 with Rifampicin 0.014 ug/mL -0.5 N.D. +0.1 -2.7 -0.2
no stress control no stress control -0.2 N.D. -0.4 -1.2 -1.5
carbon source D-Glucose (C) +0.2 N.D. -0.1 -0.8 -2.2
carbon source pyruvate (C) +0.1 N.D. -0.2 -1.0 -1.8
stress 7H9 with Clarithromycin 0.967 ug/mL -0.3 N.D. -0.3 +0.2 -2.4
stress 7H9 with Clofazimine 0.072 ug/mL +0.1 N.D. +0.2 -2.1 -0.8
stress 7H9 with Ethionamide 0.1 ug/mL -0.1 N.D. +0.2 -0.8 -1.8
stress 7H9 with Clofazimine 0.45 ug/mL +0.1 N.D. +0.5 -2.7 +0.2
stress 7H9 with Sulfaquinoxaline 0.097 mM +0.3 N.D. +0.3 +1.3 +1.4
stress 7H9 with Sulfamethizole 0.026 mM -0.0 N.D. +0.3 +1.2 +1.8
stress 7H9 with Moxifloxacin 0.121 ug/mL +0.5 N.D. -0.4 +0.5 +2.7
nitrogen source L-Alanine 10 mM (N) -0.2 N.D. +0.0 +2.1 +1.6
stress 7H9 with Levofloxacin 0.3 ug/mL +0.1 N.D. +0.1 +1.5 +2.4
stress 7H9 with Moxifloxacin 0.121 ug/mL +0.1 N.D. +0.4 +1.6 +2.2
stress 7H9 with Ofloxacin 0.8 ug/mL +0.1 N.D. -0.3 +1.7 +2.7
nitrogen source L-Glutamic 10 mM (N) -0.1 N.D. -0.5 +2.9 +2.0
nitrogen source L-Glutamic 10 mM (N) -0.2 N.D. -0.3 +2.5 +2.2
stress 7H9 with Ofloxacin 0.8 ug/mL +0.1 N.D. +0.0 +2.0 +2.4
stress 7H9 with Sulfamethizole 0.026 mM +0.2 N.D. +0.2 +1.9 +3.2
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