Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv0749A and Rv0750 are separated by 158 nucleotidesRv0750 and Rv0751c are separated by 68 nucleotidesRv0751c and Rv0752c are separated by 10 nucleotidesRv0752c and Rv0753c are separated by 6 nucleotides Rv0749A: Rv0749A - Hypothetical protein (fragment), at 841,737 to 841,874 Rv0749A Rv0750: Rv0750 - Conserved hypothetical protein, at 842,033 to 842,278 Rv0750 Rv0751c: Rv0751c - Probable 3-hydroxyisobutyrate dehydrogenase MmsB (hibadh), at 842,347 to 843,231 Rv0751c Rv0752c: Rv0752c - Probable acyl-CoA dehydrogenase FadE9, at 843,242 to 844,414 Rv0752c Rv0753c: Rv0753c - Probable methylmalonate-semialdehyde dehydrogenase MmsA (methylmalonic acid semialdehyde dehydrogenase) (MMSDH), at 844,421 to 845,953 Rv0753c
Group Condition Rv0749A Rv0750 Rv0751c Rv0752c Rv0753c
stress 7H9 with Clarithromycin 0.967 ug/mL N.D. N.D. -0.6 -0.5 -0.2
nitrogen source L-Glutamic 10 mM (N) N.D. N.D. -0.6 -0.5 -0.1
carbon source Glycerol (C) N.D. N.D. -0.2 -0.4 -0.5
nitrogen source Glycine 10 mM (N) N.D. N.D. -0.9 +0.1 -0.2
stress 7H9 with Rifampicin 0.00045 ug/mL N.D. N.D. +0.1 -0.6 -0.5
nitrogen source L-Asparagine 10 mM (N) N.D. N.D. -0.3 -0.3 -0.3
no stress control no stress control N.D. N.D. -0.3 -0.2 -0.4
stress 7H9 with Delamanid 0.236 ug/mL N.D. N.D. -0.3 -0.5 -0.0
stress 7H9 with Clofazimine 0.072 ug/mL N.D. N.D. -0.1 -0.6 -0.2
nitrogen source L-Glutamine 10 mM (N) N.D. N.D. -0.0 -0.1 -0.7
nitrogen source L-Valine 10 mM (N) N.D. N.D. +0.1 -0.3 -0.5
carbon source D-Glucose (C) N.D. N.D. -0.8 +0.2 -0.1
stress 7H9 with Rifampicin 0.014 ug/mL N.D. N.D. -0.3 +0.1 -0.5
nitrogen source L-Valine 10 mM (N) N.D. N.D. +0.2 -0.2 -0.6
nitrogen source L-Aspartic Acid 10 mM (N) N.D. N.D. -0.3 +0.2 -0.3
stress 7H9 with Ethionamide 0.1 ug/mL N.D. N.D. +0.4 +0.1 -0.6
stress 7H9 with para-aminosalicylic 0.086 ug/mL N.D. N.D. +0.6 -0.4 -0.3
carbon source Valeric 10 mM (C) N.D. N.D. +0.4 -0.5 -0.0
carbon source heptadecanoic 250 uM (C) N.D. N.D. +0.4 -0.6 +0.2
stress 7H9 with Isoniazid 0.025 ug/mL N.D. N.D. +0.5 -0.0 -0.4
carbon source Valeric 10 mM (C) N.D. N.D. +0.6 -0.3 +0.4
stress 7H9 with Moxifloxacin 0.121 ug/mL N.D. N.D. +0.5 +0.4 -0.0
no stress control no stress control N.D. N.D. +0.5 +0.2 +0.1
stress 7H9 with Levofloxacin 0.3 ug/mL N.D. N.D. +0.4 +0.4 +0.1
carbon source D,L-Malic Acid 10 mM (C) N.D. N.D. +0.5 +0.2 +0.3
carbon source casaminos 1 mg/mL (C) N.D. N.D. +0.2 +0.5 +0.3
stress 7H9 with Streptomycin 0.178 ug/mL N.D. N.D. +0.4 +0.4 +0.2
stress 7H9 with Moxifloxacin 0.121 ug/mL N.D. N.D. +0.8 +0.3 -0.0
carbon source casaminos 1 mg/mL (C) N.D. N.D. +0.5 +0.4 +0.3
stress 7H9 with Streptomycin 0.178 ug/mL N.D. N.D. +0.5 +0.5 +0.4
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