Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv0644c and Rv0645c are separated by 166 nucleotidesRv0645c and Rv0646c are separated by 46 nucleotidesRv0646c and Rv0647c are separated by 11 nucleotidesRv0647c and Rv0648 are separated by 101 nucleotides Rv0644c: Rv0644c - Methoxy mycolic acid synthase 2 MmaA2 (methyl mycolic acid synthase 2) (MMA2) (hydroxy mycolic acid synthase), at 738,297 to 739,160 Rv0644c Rv0645c: Rv0645c - Methoxy mycolic acid synthase 1 MmaA1 (methyl mycolic acid synthase 1) (MMA1) (hydroxy mycolic acid synthase), at 739,327 to 740,187 Rv0645c Rv0646c: Rv0646c - Probable lipase/esterase LipG, at 740,234 to 741,139 Rv0646c Rv0647c: Rv0647c - Conserved protein, at 741,151 to 742,617 Rv0647c Rv0648: Rv0648 - Alpha-mannosidase, at 742,719 to 746,366 Rv0648
Group Condition Rv0644c Rv0645c Rv0646c Rv0647c Rv0648
stress 7H9 with Chlorhexidine diacetate salt 0.0021 mM -0.1 -0.0 -1.3 N.D. -0.0
stress 7H9 with Chlorpromazine 0.054 mM +0.0 -0.1 -1.2 N.D. -0.1
stress 7H9 with Ethionamide 0.1 ug/mL -0.1 -0.1 -0.9 N.D. -0.2
stress 7H9 with Rifampicin 0.014 ug/mL -0.1 -0.3 -0.9 N.D. +0.0
stress 7H9 with Clarithromycin 0.967 ug/mL -0.2 -0.3 -0.7 N.D. +0.1
stress 7H9 with Chlorhexidine diacetate salt 0.0021 mM +0.2 -0.1 -1.0 N.D. -0.0
stress 7H9 with Isoniazid 0.025 ug/mL +0.1 -0.1 -0.8 N.D. -0.1
stress 7H9 with Dibucaine 0.21 mM +0.2 -0.1 -1.0 N.D. -0.0
stress 7H9 with Novobiocin 0.004 mM -0.2 -0.1 -0.8 N.D. +0.2
stress 7H9 with Clofazimine 0.072 ug/mL -0.2 +0.1 -0.7 N.D. +0.1
stress 7H9 with Rifampicin 0.014 ug/mL -0.0 +0.1 -0.9 N.D. +0.1
stress 7H9 with Bedaquiline 0.15 ug/mL +0.1 +0.1 -0.9 N.D. +0.1
stress 7H9 with Chlorpromazine 0.054 mM +0.1 +0.1 -0.9 N.D. -0.0
carbon source oleate 200uM (C) +0.2 +0.1 -0.7 N.D. -0.3
stress 7H9 with Clofazimine 0.072 ug/mL -0.1 +0.1 -0.8 N.D. +0.2
stress 7H9 with Bedaquiline 0.15 ug/mL +0.2 -0.2 -0.8 N.D. +0.2
stress 7H9 with Thioridazine 0.028 mM +0.3 +0.0 -0.7 N.D. +0.2
stress 7H9 with Pretomanid 0.213 ug/mL +0.5 -0.1 -0.4 N.D. -0.1
stress 7H9 with Geneticin G418 0.35 mM +0.1 +0.4 -0.6 N.D. -0.1
stress 7H9 with 8-hydroxy-nitroquinoline 0.03 mM +0.2 +0.3 -0.6 N.D. -0.1
carbon source cholesterol 100uM (C) -0.0 +0.6 -0.4 N.D. -0.1
stress 7H9 with Econazole nitrate salt 0.0082 mM +0.4 +0.1 -0.5 N.D. +0.2
stress 7H9 with 2-Mercaptopyridine N-oxide 0.0078 mM +0.5 +0.3 -0.7 N.D. +0.1
carbon source cholesterol 100uM (C) -0.0 +0.8 -0.2 N.D. -0.2
stress 7H9 with 2-Mercaptopyridine N-oxide 0.0078 mM +0.9 +0.1 -0.3 N.D. -0.2
stress 7H9 with Ofloxacin 0.8 ug/mL +0.3 -0.2 +0.6 N.D. -0.1
no stress control no stress control +0.2 +0.1 +0.7 N.D. -0.1
stress 7H9 with Sisomicin 0.07 mM +0.2 +0.3 +0.7 N.D. -0.1
pH pH 4.5 -0.0 +0.0 +1.3 N.D. -0.0
pH pH 4.5 +0.2 -0.0 +1.0 N.D. +0.1
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