Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv0642c and Rv0643c are separated by 64 nucleotidesRv0643c and Rv0644c are separated by 147 nucleotidesRv0644c and Rv0645c are separated by 166 nucleotidesRv0645c and Rv0646c are separated by 46 nucleotides Rv0642c: Rv0642c - Methoxy mycolic acid synthase 4 MmaA4 (methyl mycolic acid synthase 4) (MMA4) (hydroxy mycolic acid synthase), at 736,298 to 737,203 Rv0642c Rv0643c: Rv0643c - Methoxy mycolic acid synthase 3 MmaA3 (methyl mycolic acid synthase 3) (MMA3) (hydroxy mycolic acid synthase), at 737,268 to 738,149 Rv0643c Rv0644c: Rv0644c - Methoxy mycolic acid synthase 2 MmaA2 (methyl mycolic acid synthase 2) (MMA2) (hydroxy mycolic acid synthase), at 738,297 to 739,160 Rv0644c Rv0645c: Rv0645c - Methoxy mycolic acid synthase 1 MmaA1 (methyl mycolic acid synthase 1) (MMA1) (hydroxy mycolic acid synthase), at 739,327 to 740,187 Rv0645c Rv0646c: Rv0646c - Probable lipase/esterase LipG, at 740,234 to 741,139 Rv0646c
Group Condition Rv0642c Rv0643c Rv0644c Rv0645c Rv0646c
stress 7H9 with Cumene hydroperoxide 0.05 mM -5.4 -0.9 +0.2 +0.0 -0.3
stress 7H9 with Clofazimine 0.45 ug/mL -5.3 -0.1 -0.1 +0.0 -0.2
stress 7H9 with Clofazimine 0.072 ug/mL -4.6 -0.0 -0.1 +0.1 -0.8
stress 7H9 with Isoniazid 0.025 ug/mL -2.8 -0.6 +0.1 -0.1 -0.8
nitrogen source Ammonium chloride 10mM (N) -3.1 -0.4 -0.2 -0.0 -0.4
carbon source butyrate 10 mM (C) -3.2 -0.3 +0.0 -0.0 -0.3
stress 7H9 with Bedaquiline 0.15 ug/mL -3.0 +0.3 +0.2 -0.2 -0.8
nitrogen source L-Aspartic Acid 10 mM (N) -2.4 -1.0 +0.0 -0.1 +0.1
carbon source Glycerol (C) -2.4 -0.5 -0.0 -0.2 -0.3
nitrogen source L-Alanine 10 mM (N) -2.8 -0.1 -0.0 -0.2 -0.3
stress 7H9 with Novobiocin 0.004 mM -2.0 -0.2 -0.2 -0.1 -0.8
carbon source L-Asparagine (C) -2.8 -0.4 +0.3 +0.0 -0.3
carbon source Glycerol (C) -2.4 -0.3 +0.1 -0.0 -0.3
nitrogen source Urea 10mM (N) -2.5 -0.0 -0.2 +0.1 -0.4
carbon source L-Asparagine (C) -2.6 -0.7 +0.2 +0.1 +0.2
carbon source butyrate 10 mM (C) -3.0 -0.3 +0.0 +0.2 +0.3
carbon source L-Aspartic Acid (C) -2.4 -0.4 +0.3 -0.0 -0.1
carbon source Stearic 100 uM (C) -2.7 -0.4 -0.0 +0.2 +0.2
carbon source D-Glucose (C) -2.3 -0.7 +0.1 -0.0 +0.3
stress 7H9 with Rifampicin 0.00045 ug/mL -2.4 +0.8 -0.1 -0.0 -0.5
carbon source Stearic 100 uM (C) -2.1 -0.5 -0.2 +0.2 +0.3
stress 7H9 with Bedaquiline 0.15 ug/mL -1.9 +0.7 +0.1 +0.1 -0.9
stress 7H9 with Phenazine ethosulfate 0.0137 mM -2.2 +0.5 -0.0 -0.0 +0.3
stress 7H9 with Ofloxacin 0.8 ug/mL -1.9 +0.2 +0.3 -0.2 +0.6
stress 7H9 with Rifampicin 0.014 ug/mL -0.9 +1.2 -0.1 -0.3 -0.9
pH pH 4.5 -1.8 +0.2 +0.2 -0.0 +1.0
stress 7H9 with nitrite 1.5 mM; pH 5.5 +2.2 -0.3 -0.1 +0.1 +0.4
stress 7H9 with Sisomicin 0.07 mM +1.6 -0.3 +0.2 +0.3 +0.7
stress 7H9 with copper (II) chloride 0.08 mM +2.4 +0.7 +0.1 -0.3 -0.2
stress 7H9 with Dimethyl Sulfoxide 1 vol% +2.1 +0.5 +0.2 +0.3 +0.3
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