Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv0641 and Rv0642c are separated by 73 nucleotidesRv0642c and Rv0643c are separated by 64 nucleotidesRv0643c and Rv0644c are separated by 147 nucleotidesRv0644c and Rv0645c are separated by 166 nucleotides Rv0641: Rv0641 - 50S ribosomal protein L1 RplA, at 735,517 to 736,224 Rv0641 Rv0642c: Rv0642c - Methoxy mycolic acid synthase 4 MmaA4 (methyl mycolic acid synthase 4) (MMA4) (hydroxy mycolic acid synthase), at 736,298 to 737,203 Rv0642c Rv0643c: Rv0643c - Methoxy mycolic acid synthase 3 MmaA3 (methyl mycolic acid synthase 3) (MMA3) (hydroxy mycolic acid synthase), at 737,268 to 738,149 Rv0643c Rv0644c: Rv0644c - Methoxy mycolic acid synthase 2 MmaA2 (methyl mycolic acid synthase 2) (MMA2) (hydroxy mycolic acid synthase), at 738,297 to 739,160 Rv0644c Rv0645c: Rv0645c - Methoxy mycolic acid synthase 1 MmaA1 (methyl mycolic acid synthase 1) (MMA1) (hydroxy mycolic acid synthase), at 739,327 to 740,187 Rv0645c
Group Condition Rv0641 Rv0642c Rv0643c Rv0644c Rv0645c
stress 7H9 with Cumene hydroperoxide 0.05 mM N.D. -5.4 -0.9 +0.2 +0.0
stress 7H9 with Clofazimine 0.45 ug/mL N.D. -5.3 -0.1 -0.1 +0.0
stress 7H9 with Clofazimine 0.072 ug/mL N.D. -4.6 -0.0 -0.1 +0.1
nitrogen source Ammonium chloride 10mM (N) N.D. -3.1 -0.4 -0.2 -0.0
carbon source butyrate 10 mM (C) N.D. -3.2 -0.3 +0.0 -0.0
nitrogen source L-Aspartic Acid 10 mM (N) N.D. -2.4 -1.0 +0.0 -0.1
stress 7H9 with Isoniazid 0.025 ug/mL N.D. -2.8 -0.6 +0.1 -0.1
nitrogen source L-Alanine 10 mM (N) N.D. -2.8 -0.1 -0.0 -0.2
carbon source Glycerol (C) N.D. -2.4 -0.5 -0.0 -0.2
carbon source L-Asparagine (C) N.D. -2.6 -0.7 +0.2 +0.1
carbon source butyrate 10 mM (C) N.D. -3.0 -0.3 +0.0 +0.2
carbon source D-Glucose (C) N.D. -2.3 -0.7 +0.1 -0.0
carbon source Stearic 100 uM (C) N.D. -2.7 -0.4 -0.0 +0.2
carbon source L-Asparagine (C) N.D. -2.8 -0.4 +0.3 +0.0
nitrogen source Ammonium chloride 10mM (N) N.D. -2.5 -0.1 -0.3 +0.1
stress 7H9 with Phenazine methosulfate 0.0054 mM N.D. -2.7 +0.1 -0.1 -0.0
carbon source Glycerol (C) N.D. -2.4 -0.3 +0.1 -0.0
stress 7H9 with Bedaquiline 0.15 ug/mL N.D. -3.0 +0.3 +0.2 -0.2
nitrogen source Urea 10mM (N) N.D. -2.5 -0.0 -0.2 +0.1
carbon source Stearic 100 uM (C) N.D. -2.1 -0.5 -0.2 +0.2
carbon source L-Aspartic Acid (C) N.D. -2.4 -0.4 +0.3 -0.0
carbon source D-Glucose (C) N.D. -1.8 -0.8 +0.1 -0.1
carbon source propionate (C) N.D. -1.9 -0.4 -0.2 +0.2
stress 7H9 with 8-hydroxy-nitroquinoline 0.03 mM N.D. -2.3 -0.3 +0.2 +0.2
stress 7H9 with Phenazine ethosulfate 0.0137 mM N.D. -2.2 +0.5 -0.0 -0.0
stress 7H9 with Rifampicin 0.00045 ug/mL N.D. -2.4 +0.8 -0.1 -0.0
stress 7H9 with Bedaquiline 0.15 ug/mL N.D. -1.9 +0.7 +0.1 +0.1
carbon source oleate 200uM (C) N.D. -1.8 +0.8 +0.1 -0.1
stress 7H9 with copper (II) chloride 0.08 mM N.D. +2.4 +0.7 +0.1 -0.3
stress 7H9 with Dimethyl Sulfoxide 1 vol% N.D. +2.1 +0.5 +0.2 +0.3
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